Thierry Sengstag
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View article: Invasive Candida infections in solid organ transplant recipients between 2008 and 2020
Invasive Candida infections in solid organ transplant recipients between 2008 and 2020 Open
Contemporary data on the epidemiology and outcomes of invasive candidiasis (IC) in solid organ transplant recipients (SOTr) are limited. This retrospective multicenter cohort study, nested within the Swiss Transplant Cohort Study, describe…
View article: Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant
Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant Open
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. Surgical site infections can have harmful effects in liver transplant (LT) recipients. Objective To assess the incidence of SSI after …
View article: Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland
Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland Open
Patient and graft outcomes were favorable, with improved work reintegration observed at the 1-year mark post-KT for recipients from rural backgrounds compared to those from suburban and urban areas.
View article: Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation?
Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation? Open
Background Infectious diseases (IDs) are highly relevant after solid organ transplantation in terms of morbidity and mortality, being among the most common causes of death. Patients undergoing kidney retransplantation (re-K-Tx) have been a…
View article: Bacteremia During the First Year After Solid Organ Transplantation: An Epidemiological Update
Bacteremia During the First Year After Solid Organ Transplantation: An Epidemiological Update Open
Background There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr). Methods Using the Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospec…
View article: Vaccine-Preventable Infections Among Solid Organ Transplant Recipients in Switzerland
Vaccine-Preventable Infections Among Solid Organ Transplant Recipients in Switzerland Open
Importance Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden of vaccine-preventable infections (VPIs) among SOT…
View article: Data from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Data from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Radiotherapy is widely used to treat human cancer. Patients locally recurring after radiotherapy, however, have increased risk of metastatic progression and poor prognosis. The clinical management of postradiation recurrences remains an un…
View article: Supplementary Figure 2 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Figure 2 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Figure 2 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Figure 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Figure 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Figure 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Figure 2 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Figure 2 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Figure 2 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Methods and Materials from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Methods and Materials from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Methods and Materials from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Table 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Table 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Table 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Table 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Table 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Table 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Figure 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Figure 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Figure 1 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Figure 3 from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Data from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Data from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Radiotherapy is widely used to treat human cancer. Patients locally recurring after radiotherapy, however, have increased risk of metastatic progression and poor prognosis. The clinical management of postradiation recurrences remains an un…
View article: Supplementary Methods and Materials from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
Supplementary Methods and Materials from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma Open
Supplementary Methods and Materials from CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma
View article: Clinical prediction model for prognosis in kidney transplant recipients (KIDMO): study protocol
Clinical prediction model for prognosis in kidney transplant recipients (KIDMO): study protocol Open
View article: Sensing the (digital) pulse. Future steps for improving the secondary use of data for research in Switzerland
Sensing the (digital) pulse. Future steps for improving the secondary use of data for research in Switzerland Open
Introduction Ensuring that the health data infrastructure and governance permits an efficient secondary use of data for research is a policy priority for many countries. Switzerland is no exception and many initiatives have been launched t…
View article: Surgical site infections after simultaneous pancreas kidney and pancreas transplantation in the Swiss Transplant Cohort Study
Surgical site infections after simultaneous pancreas kidney and pancreas transplantation in the Swiss Transplant Cohort Study Open
View article: SwissPK<sup>cdw</sup> – A clinical data warehouse for the optimization of pediatric dosing regimens
SwissPK<sup>cdw</sup> – A clinical data warehouse for the optimization of pediatric dosing regimens Open
Clinical trials have been performed mainly in adults and accordingly the necessary information is lacking for pediatric patients, especially regarding dosage recommendation for approved drugs. This gap in information could be filled with r…
View article: Pre‐transplant donor‐specific HLA antibodies and risk for poor first‐year renal transplant outcomes: results from the Swiss Transplant Cohort Study
Pre‐transplant donor‐specific HLA antibodies and risk for poor first‐year renal transplant outcomes: results from the Swiss Transplant Cohort Study Open
The aim of this study was to analyze first year renal outcomes in a nationwide prospective multicenter cohort comprising 2215 renal transplants, with a special emphasis on the presence of pre-transplant donor-specific HLA antibodies (DSA).…
View article: SPHN – The BioMedIT Network: A Secure IT Platform for Research with Sensitive Human Data
SPHN – The BioMedIT Network: A Secure IT Platform for Research with Sensitive Human Data Open
The BioMedIT project is funded by the Swiss government as an integral part of the Swiss Personalized Health Network (SPHN), aiming to provide researchers with access to a secure, powerful and versatile IT infrastructure for doing data-driv…
View article: Data Analysis for Improving High Performance Computing Operations and Research. An Eucor Seed Money Project
Data Analysis for Improving High Performance Computing Operations and Research. An Eucor Seed Money Project Open
This work addresses the challenges associated with analysis of data generated by high performance computing (HPC) systems under data protection and privacy requirements. The HPC systems are the workhorse of simulation science, enabling uni…
View article: Addendum: The FAIR Guiding Principles for scientific data management and stewardship
Addendum: The FAIR Guiding Principles for scientific data management and stewardship Open
View article: Medical diagnoses showed low relatedness in an explorative mutual information analysis of 190,837 inpatient cases
Medical diagnoses showed low relatedness in an explorative mutual information analysis of 190,837 inpatient cases Open
In an explorative analysis, we observed a high unrelatedness of diagnoses in a tertiary-care inpatient population. This finding indicates that although multimorbidity patterns can be observed, inpatient cases frequently have further, unrel…
View article: Secondary use of routine data in hospitals: description of a scalable analytical platform based on a business intelligence system
Secondary use of routine data in hospitals: description of a scalable analytical platform based on a business intelligence system Open
We describe a scalable platform for research-oriented analyses of routine data in hospitals, which evolved from a state-of-the-art business intelligence architecture for enterprise resource planning. This platform involves an in-memory dat…
View article: Exhaustive search for epistatic effects on the human methylome
Exhaustive search for epistatic effects on the human methylome Open
Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model…
View article: Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD
Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD Open