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View article: Vitamin A acts as a potent suppressor of selenoprotein P with potential relevance for multivitamin supplementation
Vitamin A acts as a potent suppressor of selenoprotein P with potential relevance for multivitamin supplementation Open
Multivitamin supplementation is a widely used strategy to prevent disease, slow the ageing process, improve quality of life and extend life span, although recent clinical findings do not support these claims. Since selenium (Se) deficiency…
View article: PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance
PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance Open
View article: Colorectal cancer mortality is associated with low selenoprotein P status at diagnosis
Colorectal cancer mortality is associated with low selenoprotein P status at diagnosis Open
View article: Trace Element Deficiency in Axial Spondyloarthritis and Psoriatic Arthritis in Relation to Markers of Inflammation and Remission
Trace Element Deficiency in Axial Spondyloarthritis and Psoriatic Arthritis in Relation to Markers of Inflammation and Remission Open
Selenium (Se) is an essential micronutrient for antioxidant defense. Selenoproteins are involved in metabolic and signaling pathways of autoimmune and autoinflammatory diseases. Copper (Cu) and zinc (Zn) are integral components of key enzy…
View article: Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II)
Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II) Open
View article: Total and Free Zinc Dynamics as Biomarkers for Neurological Impairment in Traumatic Spinal Cord Injury
Total and Free Zinc Dynamics as Biomarkers for Neurological Impairment in Traumatic Spinal Cord Injury Open
Background/Objectives: Traumatic spinal cord injury (TSCI) profoundly impacts patients by precipitating a loss of motor and sensory capabilities, largely due to oxidative stress and inflammation during the secondary injury phase. Methods: …
View article: Circulating Glutathione Peroxidase-3 in Elderly—Association with Renal Function, Cardiovascular Mortality, and Impact of Selenium and Coenzyme Q10 Supplementation
Circulating Glutathione Peroxidase-3 in Elderly—Association with Renal Function, Cardiovascular Mortality, and Impact of Selenium and Coenzyme Q10 Supplementation Open
Low-selenium status was associated with impaired renal function, which improved after selenium and coenzyme Q10 supplementation in an RCT. Here, we evaluated serum glutathione peroxidase-3 (GPx3) and its relation to serum selenium, selenop…
View article: PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance
PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance Open
Selenocysteine (Sec) metabolism is crucial for cellular function and ferroptosis prevention and begins with the uptake of the Sec carrier, selenoprotein P (SELENOP). Following uptake, Sec released from SELENOP is metabolized via selenocyst…
View article: Serum selenium, selenoprotein P and glutathione peroxidase 3 in rheumatoid, psoriatic, juvenile idiopathic arthritis, and osteoarthritis
Serum selenium, selenoprotein P and glutathione peroxidase 3 in rheumatoid, psoriatic, juvenile idiopathic arthritis, and osteoarthritis Open
Selenoprotein P (SELENOP) controls selenium (Se) transport, and glutathione peroxidase 3 (GPx3) elicits antioxidant activity in blood. Inflammation associates with Se deficiency, but knowledge concerning selenoproteins in inflammatory rheu…
View article: Serum <scp>CD5L</scp> as potential biomarker of thyroid hormone status during pregnancy
Serum <span>CD5L</span> as potential biomarker of thyroid hormone status during pregnancy Open
The thyroid hormone (TH) status is routinely assessed by thyrotropin (TSH) and thyroxine (T4). Both biomarkers are mainly regulated by TH receptor beta, whereas many peripheral organs employ the alpha receptor. Serum cluster of differentia…
View article: The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses
The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses Open
There were no associations between selenium status and cognitive decline. However, serum selenium, but not SELENOP or GPx3 activity, was positively associated nonlinearly with global cognition at baseline. Furthermore, these associations w…
View article: New-onset autoantibodies to selenoprotein P following severe burn injury
New-onset autoantibodies to selenoprotein P following severe burn injury Open
The liver-derived selenium (Se) transporter selenoprotein P (SELENOP) declines in critical illness as a negative acute phase reactant and has recently been identified as an autoantigen. Hepatic selenoprotein biosynthesis and cotranslationa…
View article: Detection of natural autoimmunity to ghrelin in diabetes mellitus
Detection of natural autoimmunity to ghrelin in diabetes mellitus Open
Objective Ghrelin is an orexigenic peptide that becomes post-translationally modified. Natural autoantibodies to ghrelin (ghrelin-aAb) have been described in healthy subjects, in eating disorders and rheumatic diseases, with potential clin…
View article: Mikronährstoffabhängigkeit der humoralen SARS‐CoV‐2‐Impfantwort und Bedeutung der induzierten Antikörper für die männliche Fertilität
Mikronährstoffabhängigkeit der humoralen SARS‐CoV‐2‐Impfantwort und Bedeutung der induzierten Antikörper für die männliche Fertilität Open
Am 11. März 2020 erklärte die Weltgesundheitsorganisation COVID-19 zur Pandemie. Zu diesem Zeitpunkt gab es 118.000 Erkrankte in mehr als 114 Ländern und 4.291 Todesfälle. Eine Strategie zur Bekämpfung der Pandemie war die Entwicklung von …
View article: Maternal selenium deficiency during pregnancy in association with autism and ADHD traits in children: The Odense Child Cohort
Maternal selenium deficiency during pregnancy in association with autism and ADHD traits in children: The Odense Child Cohort Open
The results provide coherent evidence for selenium deficiency as a risk factor for ADHD and ASD traits in an environment with borderline supply, the causality of which should be elucidated in a randomized controlled trial.
View article: Selenium, diabetes, and their intricate sex-specific relationship
Selenium, diabetes, and their intricate sex-specific relationship Open
Selenium (Se) is an essential trace element, which is inserted as selenocysteine (Sec) into selenoproteins during biosynthesis, orchestrating their expression and activity. Se is associated with both beneficial and detrimental health effec…
View article: Low Blood Levels of Selenium, Selenoprotein P and GPx3 are Associated with Accelerated Biological Aging: Results from the Berlin Aging Study II (BASE-II)
Low Blood Levels of Selenium, Selenoprotein P and GPx3 are Associated with Accelerated Biological Aging: Results from the Berlin Aging Study II (BASE-II) Open
Introduction Biological age reflects inter-individual differences in biological function and capacity beyond chronological age. Biological age can be estimated by DNA methylation age (DNAmA) and its deviation from chronological age, DNAmA …
View article: Determination of copper status by five biomarkers in serum of healthy women
Determination of copper status by five biomarkers in serum of healthy women Open
This study suggests that the non-CP-bound copper species represent copper pools that are differently regulated from total copper or CP-bound copper, making them interesting complementary biomarkers to enable a more complete assessment of b…
View article: Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism
Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism Open
Purpose We investigated whether selenium supplementation improves quality-of-life (QoL) in patients with autoimmune thyroiditis (ID:NCT02013479). Methods We included 412 patients ≥18 years with serum thyroid peroxidase antibody (TPOAb) lev…
View article: Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial
Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial Open
View article: Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study
Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study Open
There is a dearth of data on Se status in very old adults. The aims of this study were to assess Se status and its determinants in 85-year-olds living in the Northeast of England by measuring serum Se and selenoprotein P (SELENOP) concentr…
View article: Combined copper and zinc deficiency is associated with reduced SARS-CoV-2 immunization response to BNT162b2 vaccination
Combined copper and zinc deficiency is associated with reduced SARS-CoV-2 immunization response to BNT162b2 vaccination Open
View article: Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study
Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study Open
Introduction Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence circulating seleni…
View article: Are Twin Pregnancies at Higher Risk for Iron and Calcium Deficiency than Singleton Pregnancies?
Are Twin Pregnancies at Higher Risk for Iron and Calcium Deficiency than Singleton Pregnancies? Open
The aim of this study was to compare the iron and calcium status in singleton and twin pregnancies and to assess whether there is an increased risk for iron and calcium deficiency in twin gestation. The study included 105 singleton and 9 t…
View article: Sex-specific associations of serum selenium and selenoprotein P with type 2 diabetes mellitus and hypertension in the Berlin Aging Study II
Sex-specific associations of serum selenium and selenoprotein P with type 2 diabetes mellitus and hypertension in the Berlin Aging Study II Open
View article: Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone
Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone Open
View article: Antibodies to SARS-CoV-2 in follicular fluids and their association with assisted reproduction
Antibodies to SARS-CoV-2 in follicular fluids and their association with assisted reproduction Open
Introduction Every second woman suffering from infertility asks for medical help. There is public concern that vaccination-induced antibodies (Ab) are negatively associated with fertility. A recent study has demonstrated an association bet…
View article: Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters Open
There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were …
View article: The association between selenium status and musculoskeletal function in very old adults: The Newcastle 85+ Study
The association between selenium status and musculoskeletal function in very old adults: The Newcastle 85+ Study Open
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View article: Autoantibodies to Selenoprotein P in Patients with Chronic Fatigue Syndrome Suggest Selenium Transport Impairment and Acquired Resistance to Thyroid Hormone
Autoantibodies to Selenoprotein P in Patients with Chronic Fatigue Syndrome Suggest Selenium Transport Impairment and Acquired Resistance to Thyroid Hormone Open