Thilo Weitzel
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Implication of the Mediator kinase module in CIZ1 recruitment and gene silencing by <i>Xist</i> during the initiation of X inactivation Open
In mammals, dosage compensation between the sexes is mediated by X chromosome inactivation. The long non-coding Xist RNA initiates this process. The molecular mechanism of X-linked gene silencing is beginning to be understood. We have prev…
Implication of the Mediator kinase module in CIZ1 recruitment and gene silencing by Xist during the initiation of X inactivation Open
In mammals, dosage compensation between the sexes is mediated by X chromosome inactivation. The long non-coding Xist RNA initiates this process. The molecular mechanism of X-linked gene silencing is beginning to be understood. We have prev…
Exposure Stability of Quantitative Fluorine-18 Measurements On The Biograph Vision Quadra PET/CT System Open
Background: Our aim was to determine sets of reconstruction parameters for the Biograph Vision Quadra (Siemens Healthineers) PET/CT system that result in quantitative images compliant with the European Association of Nuclear Medicine Resea…
Towards guidelines to harmonize textural features in PET: Haralick textural features vary with image noise, but exposure-invariant domains enable comparable PET radiomics Open
Haralick feature values depend strongly on exposure, but invariance exists within defined domains of exposure. Here, we present an easily replicable procedure to identify said stable exposure domains, where image noise does not substantial…
Technical Note: Transconvolution based equalization of positron energy effects for the use of <sup>68</sup>Ge/<sup>68</sup>Ga phantoms in determining <sup>18</sup>F PET recovery Open
Applying the principles of transconvolution, 18 F RCs can be recalculated from 68 Ga phantom measurements with excellent accuracy. The maximal additionally introduced error was below 0.4% of the error currently accepted for RCs in the site…
Isotope independent determination of PET/CT modulation transfer functions from phantom measurements on spheres Open
Purpose A PET/CT system's imaging capabilities are best described by its point spread function (PSF) in the spatial domain or equivalently by its modulation transfer function (MTF) in the spatial frequency domain. Knowing PSFs or MTFs is a…