Tho D. Pham
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View article: Case Report: Neonatal nephropathy with polycystic appearance in child harboring WT1 variant
Case Report: Neonatal nephropathy with polycystic appearance in child harboring WT1 variant Open
Background Mutations of the Wilms tumor suppressor-1 gene ( WT1 ) cause a WT1-related nephropathy characterized by a triad of glomerulopathy, defective genital development, and Wilms or gonadal tumor. WT1 mutations affecting the second to …
View article: Implementation of pathogen reduced cryoprecipitate for surgical services: A retrospective review of blood product utilization and fibrinogen repletion
Implementation of pathogen reduced cryoprecipitate for surgical services: A retrospective review of blood product utilization and fibrinogen repletion Open
Background Hypofibrinogenemia is associated with morbidity and mortality in trauma and surgery. Timely fibrinogen replacement is challenging due to storage regulations of cryoprecipitated antihemophilic factor (Cryo AHF ), and the product …
View article: Does total lesion prostate‐specific membrane antigen (PSMA) activity on <sup>68</sup>Ga‐PSMA PET/CT correlate with PSA and prostatectomy histopathological/clinical outcomes in patients with localised primary prostate cancer?
Does total lesion prostate‐specific membrane antigen (PSMA) activity on <sup>68</sup>Ga‐PSMA PET/CT correlate with PSA and prostatectomy histopathological/clinical outcomes in patients with localised primary prostate cancer? Open
Objectives To evaluate the relationship between total lesion PSMA (PSMA TL ), serum PSA, histopathological findings and biochemical recurrence (BCR) in patients with localised prostate cancer (PCa). Patients and methods This retrospective …
View article: Rapid Sterilization of Clinical Apheresis Blood Products Using Ultra-High Dose Rate Radiation
Rapid Sterilization of Clinical Apheresis Blood Products Using Ultra-High Dose Rate Radiation Open
Blood products, including apheresis platelets and plasma, are essential for medical use but pose risks of bacterial contamination and viral transmission. Platelets are prone to bacterial growth due to their storage conditions, while plasma…
View article: Assessing factors effecting to the selection of eco-tourism destination in Binh Chau Phuoc Buu Nature Reserve, Ba Ria - Vung Tau province
Assessing factors effecting to the selection of eco-tourism destination in Binh Chau Phuoc Buu Nature Reserve, Ba Ria - Vung Tau province Open
Sustainable ecotourism is a part of sustainable agricultural development. Sustainable Ecotourism Development contributes to biodiversity contribution, natural resource protection, and brings about sustainable livelihoods to local communiti…
View article: Disease diagnostics using machine learning of B cell and T cell receptor sequences
Disease diagnostics using machine learning of B cell and T cell receptor sequences Open
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen exposures encoded by receptors on B cel…
View article: High-throughput multiplexed serology via the mass-spectrometric analysis of isotopically barcoded beads
High-throughput multiplexed serology via the mass-spectrometric analysis of isotopically barcoded beads Open
In serology, each sample is typically tested individually, one antigen at a time. This is costly and time consuming. Serology techniques should ideally allow recurrent measurements in parallel in small sample volumes and be inexpensive and…
View article: Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation
Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation Open
BACKGROUND AND OBJECTIVES Apheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination and viral transmission. Platelet products are vulnerable to bacteri…
View article: Red Blood Cell (RBC) Antigen Confirmation Workflow – A Positive Impact at an Academic Medical Center
Red Blood Cell (RBC) Antigen Confirmation Workflow – A Positive Impact at an Academic Medical Center Open
Introduction/Objective Introduction: Blood group antigens, present on the surface of red blood cells (RBCs), play a crucial role in transfusion medicine. These antigens are recognized serologically and form the basis of RBC phenotyping. Un…
View article: O-190 Hormone-free versus FSH-primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomised clinical trial
O-190 Hormone-free versus FSH-primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomised clinical trial Open
Study question Is any hormone stimulation needed to treat infertility in women with polycystic ovary syndrome (PCOS) using in vitro maturation (IVM)? Summary answer Number of matured oocytes and pregnancy outcomes were similar without or w…
View article: Identifying Higher-Volume Antibiotic Outpatient Prescribers Using Medicare Part D Prescription Data — Arizona, 2021
Identifying Higher-Volume Antibiotic Outpatient Prescribers Using Medicare Part D Prescription Data — Arizona, 2021 Open
Background: Increased antibiotic resistance is a rising global health problem that can result from overprescribing and misusing antibiotics. The impact of antibiotic overprescribing is significant, particularly among the older adult popula…
View article: O-206 Natural, modified natural or artificial endometrial preparation strategies for frozen embryo transfer in ovulatory women (MONART): a randomized controlled trial
O-206 Natural, modified natural or artificial endometrial preparation strategies for frozen embryo transfer in ovulatory women (MONART): a randomized controlled trial Open
Study question Are live birth rates after natural (NC), modified natural (mNC) endometrial preparation superior to artificial cycle (AC) strategies for ovulatory women undergoing frozen embryo transfer? Summary answer Live birth rates were…
View article: Measuring the effectiveness of online search ads on blood donor recruitment and donation
Measuring the effectiveness of online search ads on blood donor recruitment and donation Open
Background Acutely highlighted during the COVID‐19 pandemic, the tenuousness of the blood supply continues to be a lynchpin of the most important medical procedures. Online advertisements have become a mainstay in donor recruitment. We set…
View article: P‐TS‐79 | Severe Acute Hemolytic Transfusion Reaction in a Pregnant Patient Due to Rare Anti‐Vel
P‐TS‐79 | Severe Acute Hemolytic Transfusion Reaction in a Pregnant Patient Due to Rare Anti‐Vel Open
Acute hemolytic transfusion reactions (AHTR) occur in 1:76,000 RBC transfusions. Occasionally, they are caused by non-ABO incompatible transfusions. The Vel blood group system consists of one antigen dependent on SMIM1 expression, which en…
View article: Germline-encoded specificities and the predictability of the B cell response
Germline-encoded specificities and the predictability of the B cell response Open
Antibodies result from the competition of B cell lineages evolving under selection for improved antigen recognition, a process known as affinity maturation. High-affinity antibodies to pathogens such as HIV, influenza, and SARS-CoV-2 are f…
View article: Hepatitis E virus seropositivity in an ethnically diverse community blood donor population
Hepatitis E virus seropositivity in an ethnically diverse community blood donor population Open
Background and Objectives Hepatitis E virus (HEV) is an underrecognized and emerging infectious disease that may threaten the safety of donor blood supply in many parts of the world. We sought to elucidate whether our local community blood…
View article: Micro, small, and medium enterprises (MSMEs) in fruit and vegetable value chains in Vietnam
Micro, small, and medium enterprises (MSMEs) in fruit and vegetable value chains in Vietnam Open
Stimulating nutritious diets features high on policy agendas, but designing effective interventions requires insights which are grounded in evidence and reflections on the food environment context and the needs of specific actors involved.…
View article: Germline-encoded specificities and the predictability of the B cell response
Germline-encoded specificities and the predictability of the B cell response Open
Antibodies result from the competition of B cell lineages evolving under selection for improved antigen recognition, a process known as affinity maturation. High-affinity antibodies to pathogens such as HIV, influenza, and SARS-CoV-2 are f…
View article: Hospital red blood cell and platelet supply and utilization from March to December of the first year of the <scp>COVID</scp>‐19 pandemic: The <scp>BEST</scp> collaborative study
Hospital red blood cell and platelet supply and utilization from March to December of the first year of the <span>COVID</span>‐19 pandemic: The <span>BEST</span> collaborative study Open
Background At the start of the coronavirus disease 2019 (COVID‐19) pandemic, widespread blood shortages were anticipated. We sought to determine how hospital blood supply and blood utilization were affected by the first wave of COVID‐19. S…
View article: Disease diagnostics using machine learning of immune receptors
Disease diagnostics using machine learning of immune receptors Open
Clinical diagnosis typically incorporates physical examination, patient history, and various laboratory tests and imaging studies, but makes limited use of the human system’s own record of antigen exposures encoded by receptors on B cells …
View article: Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19
Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19 Open
Glycosylation is the most common form of post-translational modification of proteins, critically affecting their structure and function. Using liquid chromatography and mass spectrometry for high-resolution site-specific quantification of …
View article: Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19
Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19 Open
Glycosylation is the most common form of post-translational modification of proteins, critically affecting their structure and function. Using liquid chromatography and mass spectrometry for high-resolution site-specific quantification of …
View article: Regulation of the BCR signalosome by the class II peptide editor, H2-M, affects the development and repertoire of innate-like B cells
Regulation of the BCR signalosome by the class II peptide editor, H2-M, affects the development and repertoire of innate-like B cells Open
The non-classical Major Histocompatibility Complex class II (MHCII) protein, H2-M, edits peptides bound to conventional MHCII in favor of stable peptide/MHCII (p/MHCII) complexes. Here, we show that H2-M deficiency affects B-1 cell surviva…
View article: How do I implement pathogen‐reduced platelets?
How do I implement pathogen‐reduced platelets? Open
Background Several risk mitigation steps have improved the safety of platelets in regard to bacterial contamination, but this continues to be a concern today. A Food and Drug Administration (FDA) Guidance issued in December 2018 aims to fu…
View article: Use of Outpatient-Derived COVID-19 Convalescent Plasma in COVID-19 Patients Before Seroconversion
Use of Outpatient-Derived COVID-19 Convalescent Plasma in COVID-19 Patients Before Seroconversion Open
Background Transfusion of COVID-19 convalescent plasma (CCP) containing high titers of anti-SARS-CoV-2 antibodies serves as therapy for COVID-19 patients. Transfusions early during disease course was found to be beneficial. Lessons from th…