Thomas A. Caputo
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View article: 8638 NEGR1 is a Mediator of Exercise-Induced Neuritogenesis in Subcutaneous White Adipose Tissue, Implications for Improved Systemic Metabolism
8638 NEGR1 is a Mediator of Exercise-Induced Neuritogenesis in Subcutaneous White Adipose Tissue, Implications for Improved Systemic Metabolism Open
Disclosure: P. Nigro: None. N.P. Carbone: None. T. Caputo: None. M. Vamvini: None. M.M. Columbus: None. M.F. Hirshman: None. R. Middelbeek: None. L.J. Goodyear: None. Emerging research shows that exercise training results in robust and ben…
View article: TIMeSynC: Temporal Intent Modelling with Synchronized Context Encodings for Financial Service Applications
TIMeSynC: Temporal Intent Modelling with Synchronized Context Encodings for Financial Service Applications Open
Users engage with financial services companies through multiple channels, often interacting with mobile applications, web platforms, call centers, and physical locations to service their accounts. The resulting interactions are recorded at…
View article: Abstracts of the ICARE 2023 77th SIAARTI National Congress
Abstracts of the ICARE 2023 77th SIAARTI National Congress Open
View article: Clinicopathologic features of endometrial cancer with mismatch repair deficiency
Clinicopathologic features of endometrial cancer with mismatch repair deficiency Open
The inclusion of DNA mismatch repair (MMR) evaluation as a standard of care for endometrial cancer management will result in a growing population of patients with MMR deficiency and negative germline Lynch syndrome testing (MMR-deficient).…
View article: Prospective Feasibility Trial of a Novel Strategy of Facilitated Cascade Genetic Testing Using Telephone Counseling
Prospective Feasibility Trial of a Novel Strategy of Facilitated Cascade Genetic Testing Using Telephone Counseling Open
PURPOSE A powerful consequence of detecting cancer-associated pathogenic variants is the ability to test at-risk relatives (ARRs), termed cascade testing. However, historical studies suggest cascade testing uptake of 30% or less. Here, we …
View article: Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and <i>MLH1</i> methylation improved the diagnosis of Lynch syndrome across the population?
Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and <i>MLH1</i> methylation improved the diagnosis of Lynch syndrome across the population? Open
Background Universal tumor testing for defective DNA mismatch repair (MMR) is recommended for all women diagnosed with endometrial cancer to identify those with underlying Lynch syndrome. However, the effectiveness of these screening metho…
View article: Evaluation of lysophosphatidic acid in vaginal fluid as a biomarker for ovarian cancer: A pilot study
Evaluation of lysophosphatidic acid in vaginal fluid as a biomarker for ovarian cancer: A pilot study Open
View article: Prevalence of nonfounder <i>BRCA1/2</i> mutations in Ashkenazi Jewish patients presenting for genetic testing at a hereditary breast and ovarian cancer center
Prevalence of nonfounder <i>BRCA1/2</i> mutations in Ashkenazi Jewish patients presenting for genetic testing at a hereditary breast and ovarian cancer center Open
Background Genetic assessment in Ashkenazi Jewish (AJ) patients often is limited to BRCA1/2 founder mutation testing. With access to time‐efficient and cost‐efficient multigene panel testing, some advocate expanding genetic testing in this…
View article: Role of adjuvant chemotherapy in the management of non-granulosa cell ovarian sex cord-stromal tumors
Role of adjuvant chemotherapy in the management of non-granulosa cell ovarian sex cord-stromal tumors Open
Adjuvant CT was associated with improved survival for patients with advanced stage non-GC SCSTs. No clear benefit was found for those with early stage disease.
View article: Minimally Invasive Staging of Apparent Stage I Malignant Ovarian Germ Cell Tumors: Prevalence and Outcomes
Minimally Invasive Staging of Apparent Stage I Malignant Ovarian Germ Cell Tumors: Prevalence and Outcomes Open
View article: Novel Fumarate Hydratase Mutation in Siblings With Early Onset Uterine Leiomyomas and Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome
Novel Fumarate Hydratase Mutation in Siblings With Early Onset Uterine Leiomyomas and Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome Open
Hereditary leiomyomatosis renal cell cancer syndrome is an autosomal dominant disorder characterized by uterine and cutaneous leiomyomas and increased predisposition to renal cell carcinoma, papillary type II. The syndrome is caused by het…
View article: A case of mesothelioma masquerading pre-operatively as ovarian cancer and brief review of the literature
A case of mesothelioma masquerading pre-operatively as ovarian cancer and brief review of the literature Open
View article: Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?
Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer? Open
Ovarian cancers diagnosed between 2000 and 2013 were examined and cases with and without endometriosis compared. Among 139 epithelial ovarian, there were 49 (35%) with endometriosis and 90 (65%) without endometriosis. Endometriosis associa…
View article: Disparities in Gynecological Malignancies
Disparities in Gynecological Malignancies Open
Health care disparities in the incidence and outcome of gynecologic cancers are complex and involve biologic factors as well as racial, socioeconomic, and geographic barriers that influence treatment and survival. These barriers must be ad…
View article: Survival Outcomes in Patients With Clear Cell Endometrial Carcinoma Are Improved With Surgery Plus Adjuvant Radiation Therapy: A Population-Based Study
Survival Outcomes in Patients With Clear Cell Endometrial Carcinoma Are Improved With Surgery Plus Adjuvant Radiation Therapy: A Population-Based Study Open
Clear cell endometrial carcinoma (CCEC) is a rare and lethal uterine malignancy with a propensity for early lymphatic and intraperitoneal spread. Surgery is the mainstay of treatment. Due to the rarity of this histology, prospective outcom…
View article: Inhibition of autophagy in peripheral blood mononuclear cells by vaginal fluid from women with a malignant adnexal mass
Inhibition of autophagy in peripheral blood mononuclear cells by vaginal fluid from women with a malignant adnexal mass Open
Inhibition of autophagy is a characteristic of ovarian cancer. We determined whether inhibition of autophagy by vaginal fluid could provide a non‐invasive test for cancer risk stratification in women presenting with an adnexal mass. Vagina…
View article: ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis Open
View article: Pelvic splenosis misdiagnosed as a uterine sarcoma
Pelvic splenosis misdiagnosed as a uterine sarcoma Open
•Splenosis is a rare complication of splenic trauma or splenectomy.•Splenosis can be mistaken for gynecologic malignancy.•Splenosis must be considered as a diagnosis in all patients with history of prior trauma or splenectomy.