Thomas A. Mackenzie
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View article: Semisynthesis of Forsyshiyanine A and a Derivative with Significant Anti-Pancreatic Cancer Activity
Semisynthesis of Forsyshiyanine A and a Derivative with Significant Anti-Pancreatic Cancer Activity Open
Forsyshiyanine A (8), a trinorditerpene alkaloid isolated from Forsythia suspensa exhibiting in vitro anti-inflammatory and antiviral activities, has been synthesized for the first time from trans-communic acid …
View article: Leaf litter associated fungi from South Africa to control fungal plant pathogens
Leaf litter associated fungi from South Africa to control fungal plant pathogens Open
Fungal genomes encode a huge biosynthetic potential to produce a wide diversity of chemical structures with valuable biological activities remaining silent or under-expressed with standard laboratory conditions. Fungal natural products pro…
View article: Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays Open
View article: Leaf-litter-associated fungi from South Africa to control fungal plant pathogens
Leaf-litter-associated fungi from South Africa to control fungal plant pathogens Open
Fungal genomes encode a huge biosynthetic potential to produce a wide diversity of chemical structures with valuable biological activities remaining silent or under-expressed with standard laboratory conditions. Fungal natural products pro…
View article: Isolation, Spectral Assignments and Absolute Configuration of a Linear Hexapeptide from the Culture Broth of the Plant-Associated Actinomycete Actinomycetospora sp. CA-287887
Isolation, Spectral Assignments and Absolute Configuration of a Linear Hexapeptide from the Culture Broth of the Plant-Associated Actinomycete Actinomycetospora sp. CA-287887 Open
A high proteolytic-resistant hexapeptide (αs1-CN 181–186) (1) along with two known 2,5-diketopiperazines, namely cyclo-(L-Pro-L-Phe) (2) and cyclo-(L-Pro-L-Tyr) (3), as well as the carboxylic acid 2-hydroxyphenylacetic acid (4), were isola…
View article: Isolation, Spectral Assignments and Absolute Configuration of a Linear Hexapeptide from the Culture Broth of the Plant-Associated Actinomycete<em> Actinomycetospora</em> sp. Ca-287887
Isolation, Spectral Assignments and Absolute Configuration of a Linear Hexapeptide from the Culture Broth of the Plant-Associated Actinomycete<em> Actinomycetospora</em> sp. Ca-287887 Open
A high proteolytic resistant hexapeptide (αs1-CN 181–186) (1) along with two known 2,5-diketopiperazines, namely cyclo-(L-Pro-L-Phe) (2) and cyclo-(L-Pro-L-Tyr) (3), and the carboxylic acid 2-hydroxyphenylacetic acid (4) were isolated from…
View article: Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals
Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals Open
The SARS coronavirus 2 (SARS-CoV-2) epidemic remains globally active. The emergence of new variants of interest and variants of concern (VoCs), which are potentially more vaccine-resistant and less sensitive to existing treatments, is evid…
View article: Discovery of bioactive natural products of microbial origin as inhibitors of the PD-1/PD-L1 protein-protein interaction
Discovery of bioactive natural products of microbial origin as inhibitors of the PD-1/PD-L1 protein-protein interaction Open
View article: Uncovering the biotechnological capacity of marine and brackish water Planctomycetota
Uncovering the biotechnological capacity of marine and brackish water Planctomycetota Open
View article: Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells
Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells Open
Cancer is one of the leading causes of death worldwide, with breast cancer being the second cause of cancer-related mortality among women. Natural Products (NPs) are one of the main sources for drug discovery. During a screening campaign f…
View article: New Eremophilane-Type Sesquiterpenes from the Marine Sediment-Derived Fungus Emericellopsis maritima BC17 and Their Cytotoxic and Antimicrobial Activities
New Eremophilane-Type Sesquiterpenes from the Marine Sediment-Derived Fungus Emericellopsis maritima BC17 and Their Cytotoxic and Antimicrobial Activities Open
The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima. On the basis of the one strain–many compounds (OSMAC) approach, four new eremophila…
View article: Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity
Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity Open
Human coronaviruses cause respiratory tract infections and are of great importance due to the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Human betacoronavirus OC43 (HCoV-OC43) is an adequate surrogate for…
View article: Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products
Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products Open
Natural Products (NPs) are one of the main sources for drug discovery. Many clinical drugs are NPs or NP-inspired compounds, and recently discovered New Chemical Entities (NCEs) of NPs are emerging as promising new drugs. High-Throughput S…
View article: Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides
Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides Open
In a survey to evaluate the potential of lichens associated with gypsum areas as sources of new antifungal metabolites, six species of lichens were collected in the gypsum outcrops of the Sorbas Desert (Diploschistes ocellatus and Seiropho…
View article: New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains
New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains Open
Antimicrobial resistance can be considered a hidden global pandemic and research must be reinforced for the discovery of new antibiotics. The spirotetronate class of polyketides, with more than 100 bioactive compounds described to date, ha…
View article: Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles
Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles Open
Cancer is considered one of the main causes of human death worldwide, being characterized by an alteration of the oxidative metabolism. Many natural compounds from plant origin with anti-tumor attributes have been described. Among them, ca…
View article: Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles
Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles Open
Cancer is considered nowadays one of the main causes of human death worldwide, being characterized by an alteration of the oxidative metabolism. Many natural compounds with anti-tumor attributes have been described, many of them from plant…
View article: Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity
Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity Open
Human coronaviruses (HCoVs) cause respiratory tract infections and are of great importance due to the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Human betacoronavirus OC43 (HCoV-OC43) is an adequate surro…
View article: Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171
Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171 Open
Memnoniella is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A Memnoniella dichroa CF-080171 extract was identified to exhibit potent activity against Plasmodium falciparum 3D7 and Tryp…
View article: Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens
Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens Open
Current needs in finding new antibiotics against emerging multidrug-resistant superbugs are pushing the scientific community into coming back to Nature for the discovery of novel active structures. Recently, a survey of halophilic actinomy…
View article: mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity
mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity Open
Forkhead box O (FOXO) proteins are transcription factors involved in cancer and aging and their pharmacological manipulation could be beneficial for the treatment of cancer and healthy aging. FOXO proteins are mainly regulated by post-tran…
View article: Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants
Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants Open
View article: A Molecular Networking Based Discovery of Diketopiperazine Heterodimers and Aspergillicins from <i>Aspergillus caelatus</i>
A Molecular Networking Based Discovery of Diketopiperazine Heterodimers and Aspergillicins from <i>Aspergillus caelatus</i> Open
The number of species in Aspergillus section Flavi has recently increased to 36 and includes some of the most important and well-known species in the genus Aspergillus. Numerous secondary metabolites, especially mycotoxins, have been repor…
View article: Antifungal mono- and dimeric nitrogenous bisabolene derivatives from a sponge in the order Bubarida from Futuna Islands
Antifungal mono- and dimeric nitrogenous bisabolene derivatives from a sponge in the order Bubarida from Futuna Islands Open
Ten nitrogenous bisabolene derivatives where isolated and structurally characterised from a Bubarida sponge collected in Futuna islands. An isocyanide bisabolene dimer showed potent antifungal activity.
View article: Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae
Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae Open
A novel cyclic antimalarial and antitrypanosome hexapeptide, pipecolisporin (1), was isolated from cultures of Nigrospora oryzae CF-298113, a fungal endophyte isolated from roots of Triticum sp. collected in a traditional agricultural land…
View article: Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria
Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria Open
Marine sponges harbor diverse microbial communities that represent a significant source of natural products. In the present study, extracts of 21 sponge-associated bacteria were screened for their antimicrobial and anticancer activity, and…
View article: Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility
Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility Open
Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas only a handful of natural an…
View article: COVID‐19 Session
COVID‐19 Session Open
Psoriasis is a common immune-mediated inflammatory skin disease with frequent multimorbidity, and immunosuppressants are the mainstay of treatment in moderate-to-severe disease.An understanding of the impact of COVID-19 on individuals with…
View article: Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents
Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents Open
View article: BESS Abstracts
BESS Abstracts Open
Purpose: The purpose of this study was to determine if demineralised bone matrix (DBM) enhanced with mesenchymal stem cells (MSCs) could improve healing when applied to a degenerative rotator cuff tear model.Methods: Eighteen female Wistar…