Thomas A. Summers
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View article: Two Accreditation Options for Biorepositories: College of American Pathologists Biorepository Accreditation Program and International Standards Organization 20387 General Requirements for Biobanking
Two Accreditation Options for Biorepositories: College of American Pathologists Biorepository Accreditation Program and International Standards Organization 20387 General Requirements for Biobanking Open
Context.— Biomedical research relies on available biomaterials and associated data, and the quality of this starting material can have a significant impact on the quality of the experimental results. In the 2000s, best-practice documents a…
View article: Tissue Eosinophilia in B-cell Lymphoma
Tissue Eosinophilia in B-cell Lymphoma Open
Tissue eosinophilia is seldom reported in B-cell lymphoma. It poses diagnostic challenges and frequently leads to the consideration of other diagnoses, particularly T-cell lymphomas. The scarce literature underscores the need for in-depth …
View article: RRx-001 Radioprotection: Enhancement of Survival and Hematopoietic Recovery in Gamma-Irradiated Mice
RRx-001 Radioprotection: Enhancement of Survival and Hematopoietic Recovery in Gamma-Irradiated Mice Open
The present studies evaluate the in vivo prophylactic radioprotective effects of 1-bromoacetyl-3, 3-dinitroazetidine (RRx-001), a phase III anticancer agent that inhibits c-myc and downregulates CD-47, after total body irradiation (TBI), i…
View article: Predictive Markers Require Thorough Analytic Validation
Predictive Markers Require Thorough Analytic Validation Open
To the Editor.—The recent editorial by Erik Thunnissen, “How to Validate Predictive Immunohistochemistry Testing in Pathology? A Practical Approach Exploiting the Heterogeneity of Programmed Death Ligand-1 Present in Non–Small Cell Lung Ca…
View article: Captopril mitigates splenomegaly and myelofibrosis in the <i>Gata1</i><sup><i>low</i></sup> murine model of myelofibrosis
Captopril mitigates splenomegaly and myelofibrosis in the <i>Gata1</i><sup><i>low</i></sup> murine model of myelofibrosis Open
Allogeneic stem cell transplantation is currently the only curative therapy for primary myelofibrosis (MF), while the JAK2 inhibitor, ruxolitinib. Has been approved only for palliation. Other therapies are desperately needed to reverse lif…
View article: Cost Effective, Flexible Ground Architecture Using Software Defined Radio and GNU Radio
Cost Effective, Flexible Ground Architecture Using Software Defined Radio and GNU Radio Open
GNU Radio is a free software library that provides the software tools to implement software defined radios. Using GNU Radio and commercially available software defined radios the team at The Naval Research Laboratory (NRL) implemented a co…
View article: Midkine and pleiotrophin concentrations in needle biopsies of breast and lung masses
Midkine and pleiotrophin concentrations in needle biopsies of breast and lung masses Open
Both MDK and PTN are readily measurable in washout of needle biopsy samples from breast and lung masses and levels are highly elevated only in a specific subset of these malignancies.
View article: The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury
The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury Open
Thus, RRx-001 may serve as a long-lived protective agent during postsurgical restoration of flow and other ischemia-reperfusion associated conditions, increasing blood flow and functional capillary density as well as preserving tissue viab…
View article: RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor
RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor Open
Small cell carcinoma of the vagina is rare, so rare in fact that the total number reported in English-language journals is less than 30. Due to this extremely low incidence, no specific treatment guidelines have been established, and most …