Explanipedia

Acute Surgery vs Conservative Treatment for Traumatic Acute Subdural Hematoma Open

Thomas A. van Essen, John K. Yue, Jason Barber, Hester F. Lingsma, Dana Pisică , et al. · 2025

Importance It is unclear whether performing surgery for most patients with an acute subdural hematoma (ASDH) and traumatic brain injury (TBI) is superior to conservative treatment. Objective To compare the effectiveness of a strategy prefe…

The current state of cranioplasty in Europe – Results from a European cranioplasty survey Open

Paul Naser, Parmenion Tsitsopoulos, Friederike Zacharias, Ana M. Castaño‐León, András Büki , et al. · 2025

The shift towards alloplastic materials in cranioplasty reflects regulatory pressures rather than material-specific considerations. Despite variability in practice, our findings underscore the need for standardized guidelines and further r…

The effectiveness and safety of decompressive craniectomy size and location in traumatic brain injury; an international, observational, comparative effectiveness study Open

Rick Vreeburg, Ranjit Singh, John K. Yue, Jeroen van Dijck, Hugo den Boogert , et al. · 2025

Intracranial pressure monitoring in traumatic brain injury: a prospective, multicenter comparative effectiveness study Open

Ms Inge van Erp, Florian van Leeuwen, Francesca Graziona, Andrew I.R. Maas, Hester F. Lingsma , et al. · 2025

Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus Open

Sami Barrit, Mejdeddine Al Barajraji, Salim El Hadwe, Alexandre Niset, Brandon Foreman , et al. · 2024

This consensus establishes foundational COS and reporting guidelines for iMMM in neurocritical care. These harmonization tools can enhance research quality, comparability, and reproducibility, facilitating evidence-based practices for this…

Disparities in casemix, acute interventions, discharge destinations and mortality of patients with traumatic brain injury between Europe and India Open

Deepak Gupta, Ranjit D. Singh, Rick Vreeburg, Jeroen TJM van Dijck, Hugo F. den Boogert , et al. · 2024

Substantial disparities between India and Europe exist along the neurotrauma care chain, with both systems being likely to face unique features and challenges in the future.

Clinical profile of patients with acute traumatic brain injury undergoing cranial surgery in the United States: report from the 18-centre TRACK-TBI cohort study Open

John K. Yue, John H. Kanter, Jason Barber, Michael C. Huang, Thomas A. van Essen , et al. · 2024

National Institute of Neurological Disorders and Stroke; US Department of Defense; Neurosurgery Research and Education Foundation.

Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study Open

John K. Yue, Leila L. Etemad, Mahmoud Elguindy, Thomas A. van Essen, Patrick Belton , et al. · 2024

Objectives An estimated 14–23% of patients with traumatic brain injury (TBI) incur multiple lifetime TBIs. The relationship between prior TBI and outcomes in patients with moderate to severe TBI (msTBI) is not well delineated. We examined …

Validation of the GCS-Pupil scale in Traumatic Brain Injury Incremental prognostic performance of pupillary reactivity with GCS in the prospective observational cohorts CENTER-TBI and TRACK-TBI Open

Rick Vreeburg, Florian D. van Leeuwen, Geoffrey A. Manley, John K. Yue, Paul Brennan , et al. · 2024

Objective To compare the incremental prognostic value of pupillary reactivity as captured in the GCS-Pupils score (GCS-P) or added as separate variable to the Glasgow Coma Scale (GCS) in traumatic brain injury (TBI). Methods We analyzed pa…

Clinical and Imaging Characteristics, Care Pathways, and Outcomes of Traumatic Epidural Hematomas: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study Open

Dana Pisică, Victor Volovici, John K. Yue, Thomas A. van Essen, Hugo F. den Boogert , et al. · 2024

BACKGROUND AND OBJECTIVES: Guideline recommendations for surgical management of traumatic epidural hematomas (EDHs) do not directly address EDHs that co-occur with other intracranial hematomas; the relative rates of isolated vs nonisolated…

Early versus delayed cranioplasty after decompressive craniectomy in traumatic brain injury: a multicenter observational study within CENTER-TBI and Net-QuRe Open

Rick Vreeburg, Ranjit D. Singh, Inge A. M. van Erp, Tommi K. Korhonen, John K. Yue , et al. · 2024

OBJECTIVE The aim of this study was to compare the outcomes of early (≤ 90 days) and delayed (> 90 days) cranioplasty following decompressive craniectomy (DC) in patients with traumatic brain injury (TBI). METHODS The authors analyzed part…

Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study Open

John K. Yue, Young Moo Lee, Xiaoying Sun, Thomas A. van Essen, Mahmoud Elguindy , et al. · 2024

OBJECTIVE The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticosteroid Randomization After Significant Head Injury (CRASH) prognostic models for mortality and outcome after tr…

Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI) Study Open

John K. Yue, Esther L. Yuh, Mahmoud Elguindy, Xiaoying Sun, Thomas A. van Essen , et al. · 2024

Isolated traumatic subarachnoid hemorrhage (tSAH) after traumatic brain injury (TBI) on head computed tomography (CT) scan is often regarded as a "mild" injury, with reduced need for additional workup. However, tSAH is also a predictor of …

Biomarker Levels in Patients with Acute Subdural Hematoma Open

O Korhonen, Rick Vreeburg, Mehrbod Mohammadian, Iftakher Hossain, Teemu M. Luoto , et al. · 2024

Best Abstract: Incremental prognostic performance of pupillary reactivity with GCS: validation of the GCS-Pupil scale in the prospective observational cohort CENTER-TBI Open

Rick Vreeburg, Florian van Leeuwen, Geoffrey A. Manley, Ewout W. Steyerberg, Paul Brennan , et al. · 2024

Identification of an Isolated Epidural Hematoma Using Blood-Based Biomarkers in Traumatic Brain Injury Open

Katja Malmi, Dana Pisică, Iftakher Hossain, Mehrbod Mohammadian, Teemu M. Luoto , et al. · 2024

The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial Open

Ranjit D. Singh, Jeroen T.J.M. van Dijck, Thomas A. van Essen, Hayden P. Nix, Rick Vreeburg , et al. · 2024

The premature termination of the RESET-ASDH study may have been related to the trial's methodology and target population with an additional impact of COVID-19. Future acute neurosurgical trials in elderly may consider these challenges to p…

Treatment-limiting decisions in patients with severe traumatic brain injury in the Netherlands Open

Inge A. M. van Erp, Thomas A. van Essen, Erwin J. O. Kompanje, Mathieu van der Jagt, Wouter A. Moojen , et al. · 2024

The crisis of the third day in intracranial pressure dynamics following traumatic brain injury, fact or fiction? Open

Ranjit D. Singh, M W H Bolscher, J.T.J.M. van Dijck, Rick Vreeburg, I.A.M. van Erp , et al. · 2024

This multicenter study challenges the 'crisis of the third day' concept. No distinct ICP or TIL elevations were observed around the third day. Elevated ICP remains a prognostic indicator, but ICP peak timing does not correlate with functio…

Age-stratified treatment variations in intracranial surgical interventions for traumatic brain injury in Europe: a prospective observational study within CENTER-TBI Open

Rick Vreeburg, Ranjit Singh, Jeroen van Dijck, Hugo den Boogert, John K. Yue , et al. · 2024

Longitudinal Recovery Following Repetitive Traumatic Brain Injury Open

Leila L. Etemad, John K. Yue, Jason Barber, Lindsay D. Nelson, Yelena G. Bodien , et al. · 2023

Importance One traumatic brain injury (TBI) increases the risk of subsequent TBIs. Research on longitudinal outcomes of civilian repetitive TBIs is limited. Objective To investigate associations between sustaining 1 or more TBIs (ie, posti…

Early surgery versus conservative treatment in patients with traumatic intracerebral hematoma: a CENTER-TBI study Open

Inge A. M. van Erp, Thomas A. van Essen, Hester F. Lingsma, Dana Pisică, Ranjit D. Singh , et al. · 2023

Purpose Evidence regarding the effect of surgery in traumatic intracerebral hematoma (t-ICH) is limited and relies on the STITCH(Trauma) trial. This study is aimed at comparing the effectiveness of early surgery to conservative treatment i…

Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study Open

Thomas A. van Essen, Inge A. M. van Erp, Hester F. Lingsma, Dana Pisică, John K. Yue , et al. · 2023

Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study Open

John K. Yue, Firas Kobeissy, Sonia Jain, Xiaoying Sun, Ryan R.L. Phelps , et al. · 2023

The relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis. The prospec…

Epidemiology Of Traumatic Brain Injury In Europe And India Open

Ranjit Singh, Rick Vreeburg, Kaveri Sharma, Thomas A. van Essen, Andrew I.R. Maas , et al. · 2023

Early Versus Late Cranioplasty After Decompressive Craniectomy In Traumatic Brain Injury Open

Rick Vreeburg, Ranjit Singh, Inge van Erp, Tommi Korrhonen, J.J. Hue , et al. · 2023

Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury Open

Inge A. M. van Erp, Iliana Michailidou, Thomas A. van Essen, Mathieu van der Jagt, Wouter A. Moojen , et al. · 2022

Traumatic brain injury: progress and challenges in prevention, clinical care, and research Open

Andrew I.R. Maas, David Menon, Geoffrey T. Manley, Mathew Abrams, Cecilia Åkerlund , et al. · 2022

A multicentre retrospective cohort study on health-related quality of life after traumatic acute subdural haematoma: does cranial laterality affect long-term recovery? Open

V. D. N. Hoogslag, Thomas A. van Essen, Mark D. Dijkman, Walid Moudrous, Guus Schoonman , et al. · 2022

Background Traumatic acute subdural haematoma is a debilitating condition. Laterality intuitively influences management and outcome. However, in contrast to stroke, this research area is rarely studied. The aim is to investigate whether th…

Mortality Reduction of Acute Surgery in Traumatic Acute Subdural Hematoma since the 19th Century: Systematic Review and Meta-Analysis with Dramatic Effect: Is Surgery the Obvious Parachute? Open

Thomas A. van Essen, Lodewijk Res, Jan W. Schoones, Godard C. W. de Ruiter, Olaf M. Dekkers , et al. · 2022

The rationale of performing surgery for acute subdural hematoma (ASDH) to reduce mortality is often compared with the self-evident effectiveness of a parachute when skydiving. Nevertheless, it is of clinical relevance to estimate the magni…

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