Thomas Alexander Gerds
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View article: Exercise Maintains LEAP2 Levels after Weight Loss in Females with Obesity
Exercise Maintains LEAP2 Levels after Weight Loss in Females with Obesity Open
View article: Real-world cardiovascular effectiveness of sustained glucagon-like peptide 1 GLP-1 receptor agonist usage in type 2 diabetes
Real-world cardiovascular effectiveness of sustained glucagon-like peptide 1 GLP-1 receptor agonist usage in type 2 diabetes Open
This real-world study confirms the cardiovascular benefits of GLP1-RAs over DPP-4is, particularly for reducing cardiovascular and all-cause mortality under continuous treatment exposure in patients with type 2 diabetes at increased cardiov…
View article: Type 2 diabetes, sodium-glucose cotransporter-2 inhibitors and cardiovascular outcomes: real world evidence versus a randomised clinical trial
Type 2 diabetes, sodium-glucose cotransporter-2 inhibitors and cardiovascular outcomes: real world evidence versus a randomised clinical trial Open
This study demonstrates the real-world effectiveness of continuous SGLT2i treatment in reducing cardiovascular events in patients with T2D and CVD. The absolute benefit of SGLT2i was larger in a real world population than in the intention …
View article: Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study
Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study Open
We have shown that significant ASCVD risk reductions are expected for remnant cholesterol lowering drugs in at-risk populations, if intervention trials with novel remnant cholesterol lowering drugs show expected reductions in remnants in l…
View article: How to identify children with cerebral palsy at risk of low bone mineral density
How to identify children with cerebral palsy at risk of low bone mineral density Open
We found 17 % of children have low BMD regardless of motoric impairment level. GMFCS score, Sparse weight bearing activity and use of anti-seizure medicine were negatively associated to BMD. No significant associations were found with vita…
View article: Cheap Subsampling bootstrap confidence intervals for fast and robust inference
Cheap Subsampling bootstrap confidence intervals for fast and robust inference Open
Bootstrapping is often applied to get confidence limits for semiparametric inference of a target parameter in the presence of nuisance parameters. Bootstrapping with replacement can be computationally expensive and problematic when cross-v…
View article: Mortality Risk Prediction Models for People With Kidney Failure
Mortality Risk Prediction Models for People With Kidney Failure Open
Importance People with kidney failure have a high risk of death and poor quality of life. Mortality risk prediction models may help them decide which form of treatment they prefer. Objective To systematically review the quality of existing…
View article: Applying the Causal Roadmap to longitudinal national registry data in Denmark: A case study of second-line diabetes medication and dementia
Applying the Causal Roadmap to longitudinal national registry data in Denmark: A case study of second-line diabetes medication and dementia Open
The Causal Roadmap is a formal framework for causal and statistical inference that supports clear specification of the causal question, interpretable and transparent statement of required causal assumptions, robust inference, and optimal p…
View article: How to Identify Children with Cerebral Palsy at Risk of Low Bone Mineral Density
How to Identify Children with Cerebral Palsy at Risk of Low Bone Mineral Density Open
View article: Targeted maximum likelihood based estimation for longitudinal mediation analysis
Targeted maximum likelihood based estimation for longitudinal mediation analysis Open
Causal mediation analysis with random interventions has become an area of significant interest for understanding time-varying effects with longitudinal and survival outcomes. To tackle causal and statistical challenges due to the complex l…
View article: Decreased Bone Turnover Markers in Children with Cerebral Palsy
Decreased Bone Turnover Markers in Children with Cerebral Palsy Open
View article: The clinical efficacy of a novel smartphone-based salivary self-test for the prediction of pre-eclampsia, pregnancy-induced hypertension and intrauterine growth restriction: a prospective cohort study
The clinical efficacy of a novel smartphone-based salivary self-test for the prediction of pre-eclampsia, pregnancy-induced hypertension and intrauterine growth restriction: a prospective cohort study Open
Introduction This study investigated the efficacy of a digital health solution utilizing smartphone images of colorimetric test-strips for home-based salivary uric acid (sUA) measurement to predict pre-eclampsia (PE), pregnancy-induced hyp…
View article: Determinants of life satisfaction in adolescents with congenital or acquired heart disease: a nationwide cross-sectional study
Determinants of life satisfaction in adolescents with congenital or acquired heart disease: a nationwide cross-sectional study Open
Background We aimed to investigate how self-reported physical and cognitive limitations (challenges), self-efficacy, and social support interacted with life satisfaction in adolescents and young adults with congenital heart disease (CHD) o…
View article: Individualised prediction of major bleeding in patients with atrial fibrillation treated with anticoagulation
Individualised prediction of major bleeding in patients with atrial fibrillation treated with anticoagulation Open
Background Anticoagulation in atrial fibrillation (AF) increases the risk of major bleeding. No predictive model has hitherto provided estimates of the absolute risk for individual patients. Aim To predict the individual 1-year risk of maj…
View article: Potential for pulp revascularization in mature anterior teeth with lateral luxation in relation to the patient’s age at the time of injury—a retrospective cohort study
Potential for pulp revascularization in mature anterior teeth with lateral luxation in relation to the patient’s age at the time of injury—a retrospective cohort study Open
View article: Comparing Glucagon‐like peptide‐1 receptor agonists versus metformin in drug‐naive patients: A nationwide cohort study
Comparing Glucagon‐like peptide‐1 receptor agonists versus metformin in drug‐naive patients: A nationwide cohort study Open
Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) are increasingly being prescribed in drug‐naive patients. We aimed to contrast add‐on therapy, adherence, and changes in biomarkers, 1 year after treatment initiation with GLP…
View article: Maternal age and body mass index and risk of labor dystocia after spontaneous labor onset among nulliparous women: A clinical prediction model
Maternal age and body mass index and risk of labor dystocia after spontaneous labor onset among nulliparous women: A clinical prediction model Open
Introduction Obstetrics research has predominantly focused on the management and identification of factors associated with labor dystocia. Despite these efforts, clinicians currently lack the necessary tools to effectively predict a woman’…
View article: Excess Risk of Mortality and Hospitalization in Patients with Heart Failure According to Age and Comorbidity – A Nationwide Register Study
Excess Risk of Mortality and Hospitalization in Patients with Heart Failure According to Age and Comorbidity – A Nationwide Register Study Open
Regardless of age, sex and comorbidity, HF was associated with excess risk of mortality and non-HF hospitalizations, but the relative risk ratio diminishes sharply with advancing age, which may influence allocation of resources for medical…
View article: The joint survival super learner: A super learner for right-censored data
The joint survival super learner: A super learner for right-censored data Open
Risk prediction models are widely used to guide real-world decision-making in areas such as healthcare and economics, and they also play a key role in estimating nuisance parameters in semiparametric inference. The super learner is a machi…
View article: Prediction model for future OHCAs based on geospatial and demographic data: An observational study
Prediction model for future OHCAs based on geospatial and demographic data: An observational study Open
This study used demographic data in a novel prediction model to identify areas with high risk of out-of-hospital cardiac arrest (OHCA) in order to target prehospital preparedness. We combined data from the nationwide Danish Cardiac Arrest …
View article: #1441 COVID-19 vaccination and risk of infection and subsequent death in patients with kidney disease
#1441 COVID-19 vaccination and risk of infection and subsequent death in patients with kidney disease Open
Background and Aims The effect of vaccinations against SARS-CoV-2 on risk of infection and subsequent adverse outcomes in patients with kidney dysfunction beyond end-stage kidney disease remains uncertain. Based on nationwide data from mul…
View article: Estimating conditional hazard functions and densities with the highly-adaptive lasso
Estimating conditional hazard functions and densities with the highly-adaptive lasso Open
We consider estimation of conditional hazard functions and densities over the class of multivariate càdlàg functions with uniformly bounded sectional variation norm when data are either fully observed or subject to right-censoring. We demo…
View article: Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease
Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease Open
The risk prediction model for kidney failure and death in people with chronic kidney disease (CKD) presented in the linked study is a super learner. A super learner is an algorithm that repeatedly splits the data into training and test set…
View article: Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study
Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study Open
Objective To train and test a super learner strategy for risk prediction of kidney failure and mortality in people with incident moderate to severe chronic kidney disease (stage G3b to G4). Design Multinational, longitudinal, population ba…
View article: WCN24-2729 Predicting the risks of kidney failure and death in adults with moderate-tosevere chronic kidney disease (KDpredict)
WCN24-2729 Predicting the risks of kidney failure and death in adults with moderate-tosevere chronic kidney disease (KDpredict) Open
Chronic kidney disease (CKD) disproportionally affects older individuals, who are more likely to die than develop kidney failure. However, treatment decisions are currently supported by tools that predict risks of kidney failure in isolati…
View article: Overweight in childhood and consumer purchases in a Danish cohort
Overweight in childhood and consumer purchases in a Danish cohort Open
Background Prevention and management of childhood overweight involves the entire family. We aimed to investigate purchase patterns in households with at least one member with overweight in childhood by describing expenditure on different f…
View article: Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years’ Follow-up From the Fit Futures Study
Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years’ Follow-up From the Fit Futures Study Open
Context Longitudinal data regarding vitamin D status in adolescence is scarce. This study presents population-based data from an Arctic adolescent population (n = 589) at 16 and 18 years. Objective The aims of this study were to investigat…
View article: Venous thromboembolism in users of hormonal contraception and non-steroidal anti-inflammatory drugs: a nationwide cohort study
Venous thromboembolism in users of hormonal contraception and non-steroidal anti-inflammatory drugs: a nationwide cohort study Open
Objective To study the influence of concomitant use of hormonal contraception and non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of venous thromboembolism. Design: Nationwide cohort study. Setting: Denmark through national regi…
View article: concrete: Targeted Estimation of Survival and Competing Risks in Continuous Time
concrete: Targeted Estimation of Survival and Competing Risks in Continuous Time Open
This article introduces the R package concrete, which implements a recently developed targeted maximum likelihood estimator (TMLE) for the cause-specific absolute risks of time-to-event outcomes measured in continuous time. Cross-validated…
View article: Risk of ankylosis of avulsed teeth immediately replanted or stored under favorable storage conditions before replantation: A <scp>long‐term</scp> clinical study
Risk of ankylosis of avulsed teeth immediately replanted or stored under favorable storage conditions before replantation: A <span>long‐term</span> clinical study Open
Background/Aim There are few long‐term clinical follow‐up studies on human teeth replanted immediately or after storage in a suitable storage medium prior to replantation. This study aimed to assess the risk of ankylosis in avulsed human t…