Thomas B. Hildebrandt
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View article: Rare cases of plural breeding in captive and wild naked mole-rats: insights into social and reproductive dynamics
Rare cases of plural breeding in captive and wild naked mole-rats: insights into social and reproductive dynamics Open
View article: Context-dependent vaginal perforation in subordinate female naked mole-rats (Heterocephalus glaber): insights into reproductive plasticity and social modulation
Context-dependent vaginal perforation in subordinate female naked mole-rats (Heterocephalus glaber): insights into reproductive plasticity and social modulation Open
While reproductive skew occurs in many social species, it is particularly pronounced in eusocial systems, where reproduction is restricted to a single breeding pair or a few individuals. In naked mole-rats ( Heterocephalus glaber ), this s…
View article: The transcriptome of the olm provides insights into its evolution and gene expression
The transcriptome of the olm provides insights into its evolution and gene expression Open
The olm ( Proteus anguinus ), with a predicted maximum lifespan of more than 100 years, is the longest-lived amphibian, which in addition possesses a range of unique adaptations to its dark, subterranean cave habitat. To assess the underly…
View article: Ultrasound-guided egg aspiration in Komodo dragons (Varanus komodoensis) with chronic egg retention
Ultrasound-guided egg aspiration in Komodo dragons (Varanus komodoensis) with chronic egg retention Open
Background Komodo dragon (Varanus komodoensis), the world's largest lizard, is endemic to the Indonesian Lesser Sunda Islands. In captivity, egg retention (dystocia) can occur because of suboptimal environmental conditions, poor nutrition,…
View article: Stereological analysis of the naked mole-rat <i>Heterocephalus glaber</i> lung provides evidence of altered surfactant function and late alveolarization
Stereological analysis of the naked mole-rat <i>Heterocephalus glaber</i> lung provides evidence of altered surfactant function and late alveolarization Open
Naked mole-rats (NMRs) can adapt to hypoxic environments and are the longest-living rodents. Comparison of their lung structure with that of mice revealed that NMRs have a reduced alveolar surface area per body weight but an increased pool…
View article: Larger brains and relatively smaller cerebella in Asian elephants compared with African savanna elephants
Larger brains and relatively smaller cerebella in Asian elephants compared with African savanna elephants Open
Elephants are the largest terrestrial animals, but our knowledge of their brains is limited. We studied brain size, proportions, and development in Asian (Elephas maximus) and African savanna (Loxodonta africana) elephants. Specifically, w…
View article: Trunk Tip Wear in Wild African Savanna Elephants
Trunk Tip Wear in Wild African Savanna Elephants Open
Synopsis The anatomy and function of tactile structures, such as vibrissae, are typically studied in captive animals, but we know little about how tactile structures compare between captive and wild animals. We analyzed trunk tip morpholog…
View article: Correction: Ethics at the Edge of Extinction: Assisted Reproductive Technologies (ART) in the Conservation of the Northern White Rhino
Correction: Ethics at the Edge of Extinction: Assisted Reproductive Technologies (ART) in the Conservation of the Northern White Rhino Open
View article: First successful cervical artificial insemination in the European roe deer (Capreolus capreolus)
First successful cervical artificial insemination in the European roe deer (Capreolus capreolus) Open
View article: A case report: Documenting intrauterine single twin death in the European roe deer (Capreolus capreolus)
A case report: Documenting intrauterine single twin death in the European roe deer (Capreolus capreolus) Open
This case report presents a rare occurrence of an intrauterine single twin demise in a captive European roe deer (Capreolus capreolus), representing to the best of our knowledge the first documented instance of this phenomenon in a wildlif…
View article: Assessment of Elephant Claustrum by Combined Histological Analysis and High-Resolution Micro-Ct
Assessment of Elephant Claustrum by Combined Histological Analysis and High-Resolution Micro-Ct Open
View article: Ethics at the Edge of Extinction: Assisted Reproductive Technologies (ART) in the Conservation of the Northern White Rhino
Ethics at the Edge of Extinction: Assisted Reproductive Technologies (ART) in the Conservation of the Northern White Rhino Open
Since assisted reproductive technologies (ART) are becoming increasingly important in wildlife conservation breeding programs, we need to discuss their implications to ensure their responsible use regarding the environment, the animals, an…
View article: Progress Toward Genetic Rescue of the Northern White Rhinoceros (Ceratotherium simum cottoni)
Progress Toward Genetic Rescue of the Northern White Rhinoceros (Ceratotherium simum cottoni) Open
The northern white rhinoceros (NWR) is functionally extinct, with only two nonreproductive females remaining. However, because of the foresight of scientists, cryopreserved cells and reproductive tissues may aid in the recovery of this spe…
View article: Advancing stem cell technologies for conservation of wildlife biodiversity
Advancing stem cell technologies for conservation of wildlife biodiversity Open
Wildlife biodiversity is essential for healthy, resilient and sustainable ecosystems. For biologists, this diversity also represents a treasure trove of genetic, molecular and developmental mechanisms that deepen our understanding of the o…
View article: Elephants develop wrinkles through both form and function
Elephants develop wrinkles through both form and function Open
The trunks of elephants have prominent wrinkles from their base to the very tip. But neither the obvious differences in wrinkles between elephant species nor their development have been studied before. In this work, we characterize the lif…
View article: Advanced assisted reproduction technologies in endangered mammalian species
Advanced assisted reproduction technologies in endangered mammalian species Open
A new synergistic approach of classical conservation strategies combined with advanced assisted reproduction technologies (aART) allows for protection and rescue of endangered keystone species at the brink of extinction, which can help to …
View article: Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts
Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts Open
Evolutionary innovations can be driven by changes in the rates of RNA translation and the emergence of new genes and small open reading frames (sORFs). In this study, we characterized the transcriptional and translational landscape of the …
View article: Fatal infection caused by a genetically distinct elephant endotheliotropic herpesvirus type 5 in a captive Asian elephant in Germany
Fatal infection caused by a genetically distinct elephant endotheliotropic herpesvirus type 5 in a captive Asian elephant in Germany Open
Background Elephant endotheliotropic herpesvirus (EEHV) infection is the most common cause for lethal hemorrhagic disease in captive juvenile Asian elephants ( Elephas maximus ). Although EEHV1 is known as the most likely cause of fatal ha…
View article: Ethical assessment of genome resource banking (GRB) in wildlife conservation
Ethical assessment of genome resource banking (GRB) in wildlife conservation Open
View article: Elephant Gestation: Insights Into Idiopathic Abortions and Stillbirth
Elephant Gestation: Insights Into Idiopathic Abortions and Stillbirth Open
The declining African and Asian elephant populations emphasize the importance of a backup population. Successful reproduction in captivity plays a key role in maintaining such a genetically diverse ex situ population but is challenged by r…
View article: Author Response: A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Author Response: A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
View article: Macrovibrissae and microvibrissae inversion and lateralization in elephants
Macrovibrissae and microvibrissae inversion and lateralization in elephants Open
Elephants are known for strongly lateralized trunk behaviors, but the mechanisms driving elephant lateralization are poorly understood. Here, we investigate features of elephant mouth organization that presumably promote lateralization. We…
View article: First fatal elephant endotheliotropic herpesvirus type 5 infection in a captive Asian elephant in Germany
First fatal elephant endotheliotropic herpesvirus type 5 infection in a captive Asian elephant in Germany Open
Background: Elephant endotheliotropic herpesvirus (EEHV) infection is the most common cause for lethal hemorrhagic disease in captive juvenile Asian elephants (Elephas maximus). Although EEHV-1 is known as the most likely cause of fatal ha…
View article: Reviewer #2 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Reviewer #2 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. Dense vascularization and intense cyto…
View article: Author response: A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Author response: A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. Dense vascularization and intense cyto…
View article: A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. Dense vascularization and intense cyto…
View article: Reviewer #4 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Reviewer #4 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. Dense vascularization and intense cyto…
View article: Reviewer #1 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Reviewer #1 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. Dense vascularization and intense cyto…
View article: Reviewer #3 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Reviewer #3 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. Dense vascularization and intense cyto…
View article: Reviewer #5 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Reviewer #5 (Public Review): A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus Open
Elephants have elaborate trunk skills and large, but poorly understood brains. Here we study trunk representations in elephant trigeminal nuclei, which form large protrusions on the ventral brainstem. Dense vascularization and intense cyto…