Explanipedia

Amygdala AVPR1A mediates susceptibility to chronic social isolation in female mice Open

Marie François, Kelly A. Vranich, Isabella Canal Delgado, Alexandre Lafond, Natalie R. Lopatinsky , et al. · 2025

Author Correction: Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials Open

Gennaro Pagano, Tanya Simuni, Nicola Pavese, Kenneth Marek, Ronald B. Postuma , et al. · 2025

Longitudinal Study of Treatment Variability for Parkinson's Disease across Specialized Centers Open

Nabila Dahodwala, Theodore Kapogiannis, Amanda Cruz, James C. Beck, Thomas L. Davis , et al. · 2025

Background Real‐world evidence on treatment practices in Parkinson's disease (PD) has been limited due to the difficulty in collecting comprehensive and generalizable clinical data. Objectives We sought to identify treatment patterns and t…

Myoclonic Dystonia: A Common Phenomenology in the Pleomorphic Movements of Angelman Syndrome Open

Robert P. Carson, Heather Riordan, Brittany Short, Thomas L. Davis, John Fang , et al. · 2025

Background Angelman syndrome (AS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, a sociable demeanor, and abnormal movements. People with AS often exhibit multiple types of abnormal movement…

Evaluating a motor progression connectivity model across Parkinson’s disease stages Open

Mallory L. Hacker, David A. Isaacs, Nanditha Rajamani, Kian Pazira, Eli Abdou , et al. · 2024

Improving Parkinson's Disease Care through Systematic Screening for Depression Open

Connie Marras, Zachary Meyer, Hongliang Liu, Sheng Luo, Sneha Mantri , et al. · 2024

Background Depression is common in Parkinson's disease (PD) but is underrecognized clinically. Although systematic screening is a recommended strategy to improve depression recognition in primary care practice, it has not been widely used …

Evaluating a Motor Progression Connectivity Model Across Parkinson’s Disease Stages Open

Mallory L. Hacker, David A. Isaacs, Nanditha Rajamani, Kian Pazira, Eli Abdou , et al. · 2024

Background Stimulation of a specific site in the dorsolateral subthalamic nucleus (STN) was recently associated with slower motor progression in Parkinson’s Disease (PD), based on the deep brain stimulation (DBS) in early-stage PD pilot tr…

Issue Information ‐ Cover Description Open

Gregory B. McKenna, Cevin Braksch, Anne‐Catherine Lehnen, Alain M. Bapolisi, Johannes Gurke , et al. · 2023

POLYMERIC MICELLES; POLYMERSOMESThe cover by Eleonora G. Hochreiner represents the process of polymerization-induced self-assembly (PISA) toward pharmaceutical application.Starting from the bottom right with the initial building blocks (hy…

Long-term neuropsychological outcomes of deep brain stimulation in early-stage Parkinson's disease Open

Mallory L. Hacker, Michael G. Tramontana, Kian Pazira, Jacqueline Meystedt, Maxim Turchan , et al. · 2023

Levodopa Carbidopa Intestinal Gel in Advanced Parkinson’s Disease: DUOGLOBE Final 3-Year Results Open

К. Ray Chaudhuri, Norbert Kovács, Francesco E. Pontieri, Jason Aldred, Paul Bourgeois , et al. · 2023

Background: Levodopa-carbidopa intestinal gel (LCIG) improves motor and non-motor symptoms in patients with advanced Parkinson’s disease (aPD). Objective: To present the final 36-month efficacy and safety results from DUOGLOBE (DUOdopa/Duo…

Connectivity Profile for Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson Disease Open

Mallory L. Hacker, Nanditha Rajamani, Clemens Neudorfer, Barbara Hollunder, Simón Oxenford , et al. · 2023

Objective This study was undertaken to describe relationships between electrode localization and motor outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early stage Parkinson disease (PD) pilot clinical trial. Met…

Racial and Ethnic Differences in Health-Related Quality of Life for Individuals With Parkinson Disease Across Centers of Excellence Open

Daniel G. Di Luca, Sheng Luo, Hongliang Liu, Mélanie Cohn, Thomas L. Davis , et al. · 2023

There were differences in PD outcomes across racial and ethnic groups, even after adjustment for sex, disease duration, HY stage, age, and some comorbid conditions. Most notably, there was worse HRQoL among non-White patients when compared…

Eleven-Year Outcomes of Deep Brain Stimulation in Early-Stage Parkinson Disease Open

Mallory L. Hacker, Jacqueline Meystedt, Maxim Turchan, Kevin R. Cannard, Kelly Harper , et al. · 2022

Issue Information ‐ Cover Description Open

Jiraya Kiriratnikom, Xun Zhang, Xiao‐Han Cao, Bo Chu, Chengjian Zhang , et al. · 2022

EXCHANGE MEMBRANES, CONDUCTIVITY, DENDRONSThe microphase separation of anion exchange membranes (AEMs) plays a critical role in constructing ion-conducting channels.The cover image, submitted by Yuanqin Zhu and colleagues for the article o…

Preliminary evidence that caffeine improves attention in multiple sclerosis Open

Kanch Sharma, Sean James Fallon, Thomas L. Davis, Scott Ankrett, Greg Munro , et al. · 2022

Early subthalamic nucleus deep brain stimulation in Parkinson’s disease reduces long-term medication costs Open

Mallory L. Hacker, Grace Cannard, Maxim Turchan, Jacqueline Meystedt, Thomas L. Davis , et al. · 2021

BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease Open

Caryl E. Sortwell, Mallory L. Hacker, D. Luke Fischer, Peter E. Konrad, Thomas L. Davis , et al. · 2021

<span>DUOGLOBE</span>: One‐Year Outcomes in a <span>Real‐World</span> Study of Levodopa Carbidopa Intestinal Gel for Parkinson's Disease Open

David G. Standaert, Jason Aldred, Marieta Anca‐Herschkovitsch, Paul Bourgeois, Esther Cubo , et al. · 2021

Background Levodopa‐carbidopa intestinal gel (LCIG) is an established treatment for improving motor and some non‐motor symptoms (NMS) in patients with advanced Parkinson's disease (PD). Prospective long‐term data in routine clinical practi…

Predicting Motor Responsiveness to Deep Brain Stimulation with Machine Learning. Open

Kevin J Krause, Fenna T. Phibbs, Thomas L. Davis, Daniel Fabbri · 2021

Deep brain stimulation is a complex movement disorder intervention that requires highly invasive brain surgery. Clinicians struggle to predict how patients will respond to this treatment. To address this problem, we are working toward deve…

Protocolizing the Workup for Idiopathic Normal Pressure Hydrocephalus Improves Outcomes Open

Lealani Mae Y. Acosta, Kassandra Stubblefield, Trisha L. Conwell, Kiersten Espaillat, Heather Koons , et al. · 2020

Implementing an INPH Protocol leads to standardized and more extensive assessment and better patient selection for and subsequent outcomes from shunting, specifically regarding gait.

Patterns and predictors of referrals to allied health services for individuals with Parkinson's disease: A Parkinson's foundation (PF) QII study Open

Angela Roberts, Miriam Rafferty, Samuel S. Wu, Guanhong Miao, Fernando Cubillos , et al. · 2020

Variations in hospitalization rates across Parkinson's Foundation Centers of Excellence Open

Florentine M.J. Zeldenrust, Sarah C. Lidstone, Samuel S. Wu, Michael S. Okun, Fernando Cubillos , et al. · 2020

Encounter rates vary even across expert centers and suggest that practices carried out in some centers may reduce the risk of hospitalization. Further research will be necessary to identify these practices and implement them more widely to…

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Sanjay Kshitij, Philipp Shinde, Michael Michael, Ying Jia, Tae‐Lim Choi , et al. · 2020

Theoretical and experimental scientists collaborate in the study of (A1-D)-(A2-D) type random copolymers for organic photovoltaics.In the article on page 2792, Ali Cirpan and colleagues investigate the effectiveness of single-atom replacem…

Application of the ‘5-2-1’ Screening Criteria in Advanced Parkinson’s Disease: Interim Analysis of DUOGLOBE Open

Jason Aldred, Marieta Anca‐Herschkovitsch, Angelo Antonini, Ovidiu Băjenaru, Lars Bergmann , et al. · 2020

Aim: A Delphi expert consensus panel proposed that fulfilling ≥1 of the '5-2-1 criteria' (≥five-times daily oral levodopa use, ≥two daily hours with 'Off' symptoms or ≥one daily hour with troublesome dyskinesia) suggests advanced Pa…

Deep brain stimulation in early-stage Parkinson disease Open

Mallory L. Hacker, Maxim Turchan, Lauren E. Heusinkveld, Amanda Currie, Sarah H. Millan , et al. · 2020

This study provides Class II evidence that DBS implanted in early-stage PD decreases the risk of disease progression and polypharmacy compared to optimal medical therapy alone.

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Takashi Doi, Yuji Yada, Kota Nishino, Makoto Sugiura, Tsutomu Shimokawa , et al. · 2020

INTRAMOLECULAR H-BONDING, POLYMIDEIn the work reported on page 969, Chunhai Chen and colleagues prepared new poly (benzimidazole imide)s with intramolecular hydrogen bonds.The H-bonding "locks" the H atom in the N-H group of benzimidazole …

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Meiling Xue, Kanghui Lv, Shengqiang Gao, Xiangzhou Lu, Yingjie Liu , et al. · 2020

In their work reported on page 885, Stewart Lewis and colleagues describe the first example of an aqueous cationic polymerization using a low cost and recyclable initiator system, phosphotungstic acid (PTA).PTA does not lose its activity t…

Issue Information ‐ Cover Description Open

Patrick Darveau, René Maltais, Jenny Roy, Donald Poirier, Jean‐François Morin , et al. · 2020

A POLY(ETHYLENE OXIDE)In their work reported on page 466, Yage Huang and colleagues characterize the melt crystallization and segmental dynamics in poly(ethylene oxide) (PEO).The three panels of the cover image show OM images of a fixed ar…

Current Practices for Outpatient Initiation of Levodopa-Carbidopa Intestinal Gel for Management of Advanced Parkinson’s Disease in the United States Open

Fahd Amjad, Danish Bhatti, Thomas L. Davis, Odinachi Oguh, Rajesh Pahwa , et al. · 2019

Thomas L. Davis YOU? Author Swipe