Thomas Boraud
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View article: Reward-driven adaptation of movements requires strong recurrent basal ganglia–cortical loops
Reward-driven adaptation of movements requires strong recurrent basal ganglia–cortical loops Open
The basal ganglia (BG) are a collection of subcortical nuclei involved in motor control, sensorimotor integration, and procedural learning. They play a key role in the acquisition and adaptation of movements, a process driven by dopamine-d…
View article: Reward-driven adaptation of movements requires strong recurrent basal ganglia-cortical loops
Reward-driven adaptation of movements requires strong recurrent basal ganglia-cortical loops Open
The basal ganglia (BG) are a collection of subcortical nuclei involved in motor control, sensorimotor integration, and procedural learning. They play a key role in the acquisition and adaptation of movements, a process driven by dopamine-d…
View article: The systematic nature of splitter cells
The systematic nature of splitter cells Open
During the past decades, hippocampal formation has undergone extensive studies, leading researchers to identify a vast collection of cells with functional properties. Several investigations, supported by carefully crafted models, have exam…
View article: The neoliberal leaning of the neuroscience discourse when it deals with mental health and learning disorders
The neoliberal leaning of the neuroscience discourse when it deals with mental health and learning disorders Open
Neuroscience attracted increasing attention in mass media during the last decades. Indeed, neuroscience advances raise high expectations in society concerning major societal issues such as mental health and learning difficulties. Unfortuna…
View article: Care of <scp>Late‐Stage</scp> Parkinsonism: Resource Utilization of the Disease in Five European Countries
Care of <span>Late‐Stage</span> Parkinsonism: Resource Utilization of the Disease in Five European Countries Open
Background Parkinson's disease (PD) is a neurodegenerative disease that leads to progressive disability. Cost studies have mainly explored the early stages of the disease, whereas late‐stage patients are underrepresented. Objective The aim…
View article: Exploring the role of structure in a time constrained decision task
Exploring the role of structure in a time constrained decision task Open
The structure of the basal ganglia is remarkably similar across a number of species (often described in terms of direct, indirect and hyperdirect pathways) and is deeply involved in decision making and action selection. In this article, we…
View article: From implicit learning to explicit representations
From implicit learning to explicit representations Open
Using the reservoir computing framework, we demonstrate how a simple model can solve an alternation task without an explicit working memory. To do so, a simple bot equipped with sensors navigates inside a 8-shaped maze and turns alternativ…
View article: Computational Models in Neurosciences Between Mechanistic and Phenomenological Characterizations
Computational Models in Neurosciences Between Mechanistic and Phenomenological Characterizations Open
Computational neuroscience combines mathematics, computer science models, and neurosciences for theorizing, investigating, and simulating neural systems involved in the development, structure, physiology, and cognitive abilities of the bra…
View article: Paul Broca: from fame to shame?
Paul Broca: from fame to shame? Open
In 2016, the University of Bordeaux named its new neuroscience building after Paul Broca. A debate was recently ignited about the appropriateness of this choice, however, given Broca’s endorsement of physiological anthropology. Thomas Bora…
View article: A Mathematical Bias
A Mathematical Bias Open
Any Mathematical framework inside which we formalize explanations limits the scope of behaviors we may consider and the type of explanations we might provide. The problem is even more acute when a model provides accurate predictions. This …
View article: Special Issue Editorial: Basal Ganglia/Movement Disorders
Special Issue Editorial: Basal Ganglia/Movement Disorders Open
This Special Issue of the European Journal of Neuroscience (EJN) is dedicated to original papers and reviews that arose from presentations given during the 13th Meeting of the International Basal Ganglia Society (IBAGS) held in Biarritz, F…
View article: Economic behaviours among non-human primates
Economic behaviours among non-human primates Open
Do we have any valid reasons to affirm that non-human primates display economic behaviour in a sufficiently rich and precise sense of the phrase? To address this question, we have to develop a set of criteria to assess the vast array of ex…
View article: The adaptive value of probability distortion and risk-seeking in macaques’ decision-making
The adaptive value of probability distortion and risk-seeking in macaques’ decision-making Open
In humans, the attitude toward risk is not neutral and is dissimilar between bets involving gains and bets involving losses. The existence and prevalence of these decision features in non-human primates are unclear. In addition, only a few…
View article: What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?
What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia? Open
Dopamine and striatal dysfunctions play a key role in the pathophysiology of Parkinson’s disease (PD) and Dystonia, but our understanding of the changes in the discharge rate and pattern of striatal projection neurons (SPNs) remains limite…
View article: Optimizing Treatment in Undertreated Late-Stage Parkinsonism: A Pragmatic Randomized Trial
Optimizing Treatment in Undertreated Late-Stage Parkinsonism: A Pragmatic Randomized Trial Open
The findings suggest that therapeutic gains may be reached even in this vulnerable group of patients with late-stage parkinsonism, but also emphasize that specialist recommendations need to be accompanied by better strategies to implement …
View article: In vivo electrophysiological validation of DREADD‐based modulation of pallidal neurons in the non‐human primate
In vivo electrophysiological validation of DREADD‐based modulation of pallidal neurons in the non‐human primate Open
Designer receptors exclusively activated by designer drugs (DREADDs) are widely used in rodents to manipulate neuronal activity and establish causal links between structure and function. Their utilization in non‐human primates (NHPs) is, h…
View article: Publisher Correction: The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism
Publisher Correction: The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Do human recordings reveal drastic modulations in the discharge of striatal projection neurons in Parkinson’s disease?
Do human recordings reveal drastic modulations in the discharge of striatal projection neurons in Parkinson’s disease? Open
Dopamine depletion of the striatum plays a key role in the pathophysiology of Parkinson’s disease (PD), but our understanding of the changes in the discharge rate and pattern of the striatal projection neurons (SPNs) remains limited. Here,…
View article: <i>In vivo</i>electrophysiological validation of DREADD-based inhibition of pallidal neurons in the non-human primate
<i>In vivo</i>electrophysiological validation of DREADD-based inhibition of pallidal neurons in the non-human primate Open
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are widely used in rodents to manipulate neuronal activity and establish causal links between structure and function. Their utilization in non-human primates (NHPs) is ho…
View article: Coordination over a unique medium of exchange under information scarcity
Coordination over a unique medium of exchange under information scarcity Open
Several micro-founded macroeconomic models with rational expectations address the issue of money emergence, by characterizing it as a coordination game. ese models have in common the use of agents who dispose of perfect or near-perfect inf…
View article: A Computational Model of Dual Competition between the Basal Ganglia and the Cortex
A Computational Model of Dual Competition between the Basal Ganglia and the Cortex Open
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