Aaron Boudreau
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View article: Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i> -Mutant Lung Cancer
Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in <i>KEAP1</i> -Mutant Lung Cancer Open
Kelch-like ECH-associated protein 1 (KEAP1) is the third most commonly mutated gene in non–small cell lung cancer and is associated with poor prognosis. In this study, we investigated synthetic lethal interaction genes in KEAP1-mutated can…
View article: Ser71 Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity
Ser71 Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity Open
The essential actin-binding factor profilin-1 (Pfn1) is a non-classical tumor suppressor with the abilities toboth inhibit cellular proliferation and augment chemotherapy-induced apoptosis. Besides actin, Pfn1 interacts with proteins harbo…
View article: Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors Open
Significance Targeting cancer metabolism requires personalized diagnostics for clinical success. Pancreatic ductal adenocarcinoma (PDAC) is characterized by metabolism addiction. To identify metabolic dependencies within PDAC, we conducted…