Thomas Brickler
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View article: Endothelial deletion of EPH receptor A4 alters single-cell profile and Tie2/Akap12 signaling to preserve blood–brain barrier integrity
Endothelial deletion of EPH receptor A4 alters single-cell profile and Tie2/Akap12 signaling to preserve blood–brain barrier integrity Open
Neurobiological consequences of traumatic brain injury (TBI) result from a complex interplay of secondary injury responses and sequela that mediates chronic disability. Endothelial cells are important regulators of the cerebrovascular resp…
View article: Overexpression of CD47 is associated with brain overgrowth and 16p11.2 deletion syndrome
Overexpression of CD47 is associated with brain overgrowth and 16p11.2 deletion syndrome Open
Copy number variation (CNV) at the 16p11.2 locus is associated with neuropsychiatric disorders, such as autism spectrum disorder and schizophrenia. CNVs of the 16p gene can manifest in opposing head sizes. Carriers of 16p11.2 deletion tend…
View article: Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions Open
In Alzheimer's disease (AD) and other neurodegenerative disorders, oligodendroglial failure is a common early pathological feature, but how it contributes to disease development and progression, particularly in the gray matter of the brain…
View article: Overexpression of CD47 is associated with brain overgrowth in 16p11.2 deletion syndrome
Overexpression of CD47 is associated with brain overgrowth in 16p11.2 deletion syndrome Open
One of the most common genetic linkages associated with neuropsychiatric disorders, such as autism spectrum disorder and schizophrenia, occurs at the 16p11.2 locus. Copy number variants (CNVs) of the 16p gene can manifest in opposing head …
View article: Transient Treatment of Human Pluripotent Stem Cells with DMSO to Promote Differentiation
Transient Treatment of Human Pluripotent Stem Cells with DMSO to Promote Differentiation Open
Despite the growing use of pluripotent stem cells (PSCs), challenges in efficiently differentiating embryonic and induced pluripotent stem cells (ESCs and iPSCs) across various lineages remain. Numerous differentiation protocols have been …
View article: A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family Open
The propensity for differentiation varies substantially across human pluripotent stem cell (hPSC) lines, greatly restricting the use of hPSCs for cell replacement therapy or disease modeling. Here, we investigate the underlying mechanisms …
View article: Angiopoietin/Tie2 Axis Regulates the Age-at-Injury Cerebrovascular Response to Traumatic Brain Injury
Angiopoietin/Tie2 Axis Regulates the Age-at-Injury Cerebrovascular Response to Traumatic Brain Injury Open
Although age-at-injury influences chronic recovery from traumatic brain injury (TBI), the differential effects of age on early outcome remain understudied. Using a male murine model of moderate contusion injury, we investigated the underly…
View article: Age-Dependent Responses Following Traumatic Brain Injury
Age-Dependent Responses Following Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a growing health concern worldwide that affects a broad range of the population. As TBI is the leading cause of disability and mortality in children, several preclinical models have been developed using rode…
View article: Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury
Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury Open
Traumatic and nontraumatic brain injury results from severe disruptions in the cellular microenvironment leading to massive loss of neuronal populations and increased neuroinflammation. The progressive cascade of secondary events, includin…
View article: Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury
Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury Open
Restoration of learning and memory deficits following traumatic brain injury (TBI) is attributed, in part, to enhanced neural stem/progenitor cell (NSPCs) function. Recent findings suggest gap junction (GJ)-associated connexin 43 (Cx43) pl…
View article: The Role of Age and Model Severity on Cortical Vascular Response Following Traumatic Brain Injury
The Role of Age and Model Severity on Cortical Vascular Response Following Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a growing health concern worldwide that affects a broad range of the population. As TBI is the leading cause of disability and mortality in children, several pre-clinical models have been developed using rod…
View article: Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury
Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury Open
Traumatic brain injury (TBI) elicits the immediate production of proinflammatory cytokines which participate in regulating the immune response. While the mechanisms of adaptive immunity in secondary injury are well characterized, the role …