Thomas Brüls
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View article: Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters
Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters Open
The continuous growth of global plastics production, including polyesters, has resulted in increasing plastic pollution and subsequent negative environmental impacts. Therefore, enzyme-catalyzed depolymerization of synthetic polyesters as …
View article: Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitats
Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitats Open
Example of a very simple microbial food chain in groundwater consisting of only two micro organisms
View article: Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families
Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families Open
Metagenomics has made accessible an enormous reserve of global biochemical diversity. To tap into this vast resource of novel enzymes, we have screened over one million clones from metagenome DNA libraries derived from sixteen different en…
View article: Microbial Degradation of a Recalcitrant Pesticide: Chlordecone
Microbial Degradation of a Recalcitrant Pesticide: Chlordecone Open
Chlordecone (Kepone®) is a synthetic organochlorine insecticide (C10Cl10O) used worldwide mostly during the 1970 and 1980s. Its intensive application in the French West Indies to control the banana black weevil Cosmopolites sordidus led to…
View article: Shared Nearest Neighbor clustering in a Locality Sensitive Hashing framework
Shared Nearest Neighbor clustering in a Locality Sensitive Hashing framework Open
We present a new algorithm to cluster high dimensional sequence data, and its application to the field of metagenomics, which aims to reconstruct individual genomes from a mixture of genomes sampled from an environ-mental site, without any…
View article: A spectral algorithm for fast de novo layout of uncorrected long nanopore reads
A spectral algorithm for fast de novo layout of uncorrected long nanopore reads Open
Motivation: New long read sequencers promise to transform sequencing and genome assembly by producing reads tens of kilobases long. However their high error rate significantly complicates assembly and requires expensive correction steps to…
View article: The enzymatic nature of an anonymous protein sequence cannot reliably be inferred from superfamily level structural information alone
The enzymatic nature of an anonymous protein sequence cannot reliably be inferred from superfamily level structural information alone Open
As the largest fraction of any proteome does not carry out enzymatic functions, and in order to leverage 3D structural data for the annotation of increasingly higher volumes of sequence data, we wanted to assess the strength of the link be…