Thomas Brüning
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View article: Supplementary Figure from Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)
Supplementary Figure from Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY) Open
Supplementary Figure from Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)
View article: UROfast – a multiplex Lateral Flow Assay (LFA) for urinary biomarkers to identify bladder cancer patients
UROfast – a multiplex Lateral Flow Assay (LFA) for urinary biomarkers to identify bladder cancer patients Open
View article: SARS‐CoV‐2 Antibody Levels and Infections in Multiple Vaccinated Employees Over Time
SARS‐CoV‐2 Antibody Levels and Infections in Multiple Vaccinated Employees Over Time Open
This prospective cohort study aimed to monitor the humoral immune response to SARS‐CoV‐2 proteins over 3 years in relation to repeated vaccination or infection. Quantitative immunoassays traceable to international IgG units were used to me…
View article: 8277626 Application of bias analysis: the case of socioeconomic status and lung cancer in a pooled international case-control study
8277626 Application of bias analysis: the case of socioeconomic status and lung cancer in a pooled international case-control study Open
View article: 8288908 Altered coordination between sleep timing and cortisol profiles in night-working female hospital employees
8288908 Altered coordination between sleep timing and cortisol profiles in night-working female hospital employees Open
View article: 8288298 Interventions to reduce exposure to welding fumes in gas metal arc welding at the workplace – Progress of the INTERWELD study
8288298 Interventions to reduce exposure to welding fumes in gas metal arc welding at the workplace – Progress of the INTERWELD study Open
View article: Altered Coordination Between Sleep Timing and Cortisol Profiles in Night-Working Female Hospital Employees
Altered Coordination Between Sleep Timing and Cortisol Profiles in Night-Working Female Hospital Employees Open
View article: Aktualisierung der Leitlinie Blei
Aktualisierung der Leitlinie Blei Open
Update of the Guideline on Lead – Prevention and early detection of work-related health hazards in activities involving the exposure to lead and its inorganic compounds (except lead arsenates and lead chromates) The updated guideline is es…
View article: The Effect of Alcohol‐Based Virucidal Hand Sanitizers on Skin Barrier Function—A Randomised Experimental Study
The Effect of Alcohol‐Based Virucidal Hand Sanitizers on Skin Barrier Function—A Randomised Experimental Study Open
Background Applying alcohol‐based hand rubs (ABHRs) is a proven means of combating hand‐borne microorganisms. In addition to their bactericidal activity, some rubs also have virucidal properties (ABVHRs). Frequent use of ABHRs can result i…
View article: Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer
Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer Open
The role of germline genetics in adjuvant aromatase inhibitor (AI) treatment efficacy in ER-positive breast cancer is poorly understood. We employed a two-stage candidate gene approach to examine associations between survival endpoints and…
View article: Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank
Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank Open
The German Environmental Specimen Bank (ESB) annually archives 24-h urine samples since the early 1980s. In this study, we analyzed 420 of these samples from the years 2014 to 2022 for metabolites of 18 phthalates and two substitutes. We m…
View article: Urinary DNA-methylation and protein biomarkers identify urothelial carcinoma among other genitourinary diseases and cancer-free individuals
Urinary DNA-methylation and protein biomarkers identify urothelial carcinoma among other genitourinary diseases and cancer-free individuals Open
View article: Bias analysis on socioeconomic status and lung cancer in a pooled international case-control study
Bias analysis on socioeconomic status and lung cancer in a pooled international case-control study Open
Background Low socioeconomic status (SES) groups showed increased lung cancer risks even after adjustment for smoking habits and other exposures to lung carcinogens. Although several biases were often indicated and discussed, only few stud…
View article: Limitationen und methodisches Vorgehen bei Ableitung einer Risikoverdopplungsdosis aus publizierten kategoriellen Daten
Limitationen und methodisches Vorgehen bei Ableitung einer Risikoverdopplungsdosis aus publizierten kategoriellen Daten Open
Zusammenfassung Hintergrund Zur Anerkennung einer beruflich verursachten Lungenkrebserkrankung nach Exposition gegenüber hexavalentem Chrom wurde eine Risikoverdopplungsdosis von 500 µg/m 3 -Jahren als Orientierungsmaß vorgeschlagen. Ziel …
View article: Der Nachweis beruflich verursachter Allergien ist ein komplexes Unterfangen: ein Fallbeispiel
Der Nachweis beruflich verursachter Allergien ist ein komplexes Unterfangen: ein Fallbeispiel Open
The detection of occupational allergies is a complex undertaking: A case study According to the recommendations for the diagnosis of occupational asthma, suspected cases require a confirmed asthma diagnosis, work-associated symptoms, evide…
View article: Zinc fever in a painter and varnisher: a case report
Zinc fever in a painter and varnisher: a case report Open
View article: Influence of uncomfortable environmental conditions on odor detection thresholds for n-butanol determined with a dynamic dilution olfactometer and in room air
Influence of uncomfortable environmental conditions on odor detection thresholds for n-butanol determined with a dynamic dilution olfactometer and in room air Open
Odor guide values (OGV) are used when a person is exposed to an odor in a room and complains about odor annoyance. OGV are derived from odor detection thresholds (ODT) measured under standard environmental conditions. The study question wa…
View article: Comparison of odor detection thresholds for n-butanol and benzaldehyde determined with a dynamic dilution olfactometer and in room air
Comparison of odor detection thresholds for n-butanol and benzaldehyde determined with a dynamic dilution olfactometer and in room air Open
The German Committee on Indoor Air Guide Values (AIR) has developed a concept of odor guide values (OGV) based on odor detection thresholds (ODT) to assess the plausibility of complaints about odor annoyance. ODT were determined directly a…
View article: Synthetic silica fibers of different length, diameter and shape: synthesis and interaction with rat (NR8383) and human (THP-1) macrophages in vitro, including chemotaxis and gene expression profile
Synthetic silica fibers of different length, diameter and shape: synthesis and interaction with rat (NR8383) and human (THP-1) macrophages in vitro, including chemotaxis and gene expression profile Open
View article: Changes in mental distress among employees during the three years of the COVID-19 pandemic in Germany
Changes in mental distress among employees during the three years of the COVID-19 pandemic in Germany Open
Objectives The COVID-19 pandemic changed the future of work sustainably and led to a general increase in mental stress. A study conducted during the second and third pandemic wave with a retrospective survey of the first wave among 1,545 n…
View article: Altered coordination between sleep timing and cortisol profiles in night working female hospital employees
Altered coordination between sleep timing and cortisol profiles in night working female hospital employees Open
Our findings indicate altered cortisol profiles in female hospital employees on night shifts. Specifically, cortisol levels were lower at night when higher levels would typically be necessary for work activities, and higher at bedtime afte…
View article: Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients
Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients Open
MALAT1, GAS5, and calretinin could be potential biomarkers for the prediction of tumor recurrence, improving the benefit from multimodal treatment including cytoreductive surgery.
View article: Biomonitoring of volatile organic compounds and organophosphorus flame retardands in commercial aircrews after „fume and smell events“
Biomonitoring of volatile organic compounds and organophosphorus flame retardands in commercial aircrews after „fume and smell events“ Open
Health risks to humans after "fume and smell events", short-term incidents on aircrafts that are accompanied by unpleasant odour or visible smoke, remain a subject of controversy. We assessed exposure to volatile organic compounds (VOC) an…
View article: Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring
Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring Open
Homosalate (HMS) is a UV filter used in sunscreens and personal care products as a mixture of cis - and trans -isomers. Systemic absorption after sunscreen use has been demonstrated in humans, and concerns have been raised about possible e…
View article: Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk
Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk Open
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consort…
View article: Aufbau einer Bio- und Forschungsdatenbank zu Schichtarbeit: Erfahrungen aus der Praxis zur Harmonisierung von Studien
Aufbau einer Bio- und Forschungsdatenbank zu Schichtarbeit: Erfahrungen aus der Praxis zur Harmonisierung von Studien Open
View article: Human biomonitoring of neonicotinoid exposures: case studies after the use of a spray-agent to ornamental plants and a topical medication to pets
Human biomonitoring of neonicotinoid exposures: case studies after the use of a spray-agent to ornamental plants and a topical medication to pets Open
Acetamiprid (ACE) and imidacloprid (IMI) are insecticides of global importance and are used as spray and watering agents for ornamental plants to control biting and sucking insects or as topical medications on pets to remove and control fl…
View article: Identification, Organic Synthesis, and Sensitive Analysis of a <i>cis</i>-Homosalate-Specific Exposure Biomarker
Identification, Organic Synthesis, and Sensitive Analysis of a <i>cis</i>-Homosalate-Specific Exposure Biomarker Open
Homosalate (HMS) is an organic UV filter used in sunscreens and personal care products. Despite its widespread use and detection in environmental matrices, little is known regarding its exposure in humans. HMS is used as a mixture of ci…
View article: Reply on the comments of Ulla Vogel and colleagues on their recently published paper entitled “Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on ‘Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?’ by Christian Monsé et al.”
Reply on the comments of Ulla Vogel and colleagues on their recently published paper entitled “Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on ‘Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?’ by Christian Monsé et al.” Open
View article: Use of Multiple Machine Learning Approaches for Selecting Urothelial Cancer-Specific DNA Methylation Biomarkers in Urine
Use of Multiple Machine Learning Approaches for Selecting Urothelial Cancer-Specific DNA Methylation Biomarkers in Urine Open
Diagnosing urothelial cancer (UCa) via invasive cystoscopy is painful, specifically in men, and can cause infection and bleeding. Because the UCa risk is higher for male patients, urinary non-invasive UCa biomarkers are highly desired to s…