Thomas C. Gasser
YOU?
Author Swipe
View article: Corrigendum to “Fracture of porcine aorta—Part 1: symconCT fracture testing and DIC” [Acta Biomaterialia 2023, 167, 147-157]
Corrigendum to “Fracture of porcine aorta—Part 1: symconCT fracture testing and DIC” [Acta Biomaterialia 2023, 167, 147-157] Open
View article: Fracture properties of porcine versus human thoracic aortas from tricuspid/bicuspid aortic valve patients via symmetry-constraint Compact Tension testing
Fracture properties of porcine versus human thoracic aortas from tricuspid/bicuspid aortic valve patients via symmetry-constraint Compact Tension testing Open
View article: Early Prediction of Abdominal Aortic Aneurysm Rupture Risk Using Numerical Biomechanical Analysis
Early Prediction of Abdominal Aortic Aneurysm Rupture Risk Using Numerical Biomechanical Analysis Open
Objective: We aimed to predict patient-specific rupture risks and growth behaviors in abdominal aortic aneurysm (AAA) patients using biomechanical evaluation with finite element analysis to establish an additional AAA repair threshold besi…
View article: Peak wall rupture index is associated with risk of rupture of abdominal aortic aneurysms, independent of size and sex
Peak wall rupture index is associated with risk of rupture of abdominal aortic aneurysms, independent of size and sex Open
Background Information on the predictive determinants of abdominal aortic aneurysm rupture from CT angiography are scarce. The aim of this study was to investigate biomechanical parameters in abdominal aortic aneurysms and their associatio…
View article: Abdominal aortic aneurysms’ histomorphology differs on the individual patient level and is not associated with classic risk factors – the HistAAA study
Abdominal aortic aneurysms’ histomorphology differs on the individual patient level and is not associated with classic risk factors – the HistAAA study Open
Objective Abdominal aortic aneurysm (AAA) treatment is upon a diameter threshold by open (OAR) or endovascular aortic repair. So far, attempts for medical growth abrogation have failed. This study aims to elucidate the heterogeneity of AAA…
View article: An enhanced deep learning approach for vascular wall fracture analysis
An enhanced deep learning approach for vascular wall fracture analysis Open
This work outlines an efficient deep learning approach for analyzing vascular wall fractures using experimental data with openly accessible source codes ( https://doi.org/10.25835/weuhha72 ) for reproduction. Vascular disease remains the p…
View article: The white matter fiber tract deforms most in the perpendicular direction during<i>in vivo</i>volunteer impacts
The white matter fiber tract deforms most in the perpendicular direction during<i>in vivo</i>volunteer impacts Open
White matter (WM) tract-related strains are increasingly used to quantify brain mechanical responses, but their dynamics in live human brains during in vivo impact conditions remain largely unknown. Existing research primarily looked into …
View article: On the Impact of Residual Strains in the Stress Analysis of Patient-Specific Atherosclerotic Carotid Vessels: Predictions Based on the Homogenous Stress Hypothesis
On the Impact of Residual Strains in the Stress Analysis of Patient-Specific Atherosclerotic Carotid Vessels: Predictions Based on the Homogenous Stress Hypothesis Open
View article: Merging Geometrical, Biomechanical, and Clinical Data To Assess the Rupture Risk of Abdominal Aortic Aneurysms
Merging Geometrical, Biomechanical, and Clinical Data To Assess the Rupture Risk of Abdominal Aortic Aneurysms Open
Objective: Reinforced by the latest ESVS guidelines, the maximum diameter remains almost the sole indicator for abdominal aortic aneurysm (AAA) repair. Introduced in 1999, it reflects a very conservative decision making, resulting in the e…
View article: Simulation of fracture in vascular tissue: coupling a continuum damage formulation with an embedded representation of fracture
Simulation of fracture in vascular tissue: coupling a continuum damage formulation with an embedded representation of fracture Open
View article: Fracture of porcine aorta—Part 2: FEM modelling and inverse parameter identification
Fracture of porcine aorta—Part 2: FEM modelling and inverse parameter identification Open
The mechanics of vascular tissue, particularly its fracture properties, are crucial in the onset and progression of vascular diseases. Vascular tissue properties are complex, and the identification of fracture mechanical properties relies …
View article: Fracture of porcine aorta—Part 1: symconCT fracture testing and DIC
Fracture of porcine aorta—Part 1: symconCT fracture testing and DIC Open
Tissue failure and damage are inherent parts of vascular diseases and tightly linked to clinical events. Additionally, experimental set-ups designed to study classical engineering materials are suboptimal in the exploration of vessel wall …
View article: Three-dimensional growth and biomechanical risk progression of abdominal aortic aneurysms under serial computed tomography assessment
Three-dimensional growth and biomechanical risk progression of abdominal aortic aneurysms under serial computed tomography assessment Open
View article: Geometrically exact beam theory with embedded strong discontinuities for the modeling of failure in structures. Part I: Formulation and finite element implementation
Geometrically exact beam theory with embedded strong discontinuities for the modeling of failure in structures. Part I: Formulation and finite element implementation Open
International audience
View article: Association between aortic peak wall stress and rupture index with abdominal aortic aneurysm–related events
Association between aortic peak wall stress and rupture index with abdominal aortic aneurysm–related events Open
View article: Continuum damage micromechanics description of the compressive failure mechanisms in sustainable biocomposites and experimental validation
Continuum damage micromechanics description of the compressive failure mechanisms in sustainable biocomposites and experimental validation Open
View article: Biomechanical Assessment of Macro-Calcification in Human Carotid Atherosclerosis and Its Impact on Smooth Muscle Cell Phenotype
Biomechanical Assessment of Macro-Calcification in Human Carotid Atherosclerosis and Its Impact on Smooth Muscle Cell Phenotype Open
Intimal calcification and vascular stiffening are predominant features of end-stage atherosclerosis. However, their role in atherosclerotic plaque instability and how the extent and spatial distribution of calcification influence plaque bi…
View article: A bottom-up approach to model collagen fiber damage and failure in soft biological tissues
A bottom-up approach to model collagen fiber damage and failure in soft biological tissues Open
Understanding the damage and failure of load-carrying soft biological tissue is critical in the effectual treatment of injury and disease. The difficulty in experimentally identifying the intrinsic mechanisms by which damage initiates and …
View article: Patient-specific biomechanical analysis of atherosclerotic plaques enabled by histologically validated tissue characterization from computed tomography angiography: A case study
Patient-specific biomechanical analysis of atherosclerotic plaques enabled by histologically validated tissue characterization from computed tomography angiography: A case study Open
Patient specific tissue characterization can identify distributions of stress and strain in a clinically relevant range. This capability may be used to identify high-risk lesions and personalize treatment decisions for individual patients …
View article: Peak Wall Stress and Peak Wall Rupture Index are Associated with Time to Rupture in Abdominal Aortic Aneurysms
Peak Wall Stress and Peak Wall Rupture Index are Associated with Time to Rupture in Abdominal Aortic Aneurysms Open
Introduction: Maximal aneurysm diameter (MAD) is used as a risk-threshold for abdominal aortic aneurysm (AAA) surgery1,2. Some AAAs, however, rupture before this threshold, and many may remain stable until large diameters3. Peak wall stres…
View article: A quarter of a century biomechanical rupture risk assessment of abdominal aortic aneurysms. Achievements, clinical relevance, and ongoing developments
A quarter of a century biomechanical rupture risk assessment of abdominal aortic aneurysms. Achievements, clinical relevance, and ongoing developments Open
Abdominal aortic aneurysm (AAA) disease, the local enlargement of the infrarenal aorta, is a serious condition that causes many deaths, especially in men exceeding 65 years of age. Over the past quarter of a century, computational biomecha…
View article: Athero-occlusive Disease Appears to be Associated with Slower Abdominal Aortic Aneurysm Growth: An Exploratory Analysis of the TEDY Trial
Athero-occlusive Disease Appears to be Associated with Slower Abdominal Aortic Aneurysm Growth: An Exploratory Analysis of the TEDY Trial Open
View article: Geometric and biomechanical modeling aided by machine learning improves the prediction of growth and rupture of small abdominal aortic aneurysms
Geometric and biomechanical modeling aided by machine learning improves the prediction of growth and rupture of small abdominal aortic aneurysms Open
View article: Pliable, Scalable, and Degradable Scaffolds with Varying Spatial Stiffness and Tunable Compressive Modulus Produced by Adopting a Modular Design Strategy at the Macrolevel
Pliable, Scalable, and Degradable Scaffolds with Varying Spatial Stiffness and Tunable Compressive Modulus Produced by Adopting a Modular Design Strategy at the Macrolevel Open
Clinical results obtained when degradable polymer-based medical devices are used in breast reconstruction following mastectomy are promising. However, it remains challenging to develop a large scaffold structure capable of providing both s…
View article: Modeling multi-fracturing fibers in fiber networks using elastoplastic Timoshenko beam finite elements with embedded strong discontinuities — Formulation and staggered algorithm
Modeling multi-fracturing fibers in fiber networks using elastoplastic Timoshenko beam finite elements with embedded strong discontinuities — Formulation and staggered algorithm Open
To model fiber failures in random fiber networks, we have developed an elastoplastic Timoshenko beam finite element with embedded discontinuities. The method is based on the theory of strong discontinuities where the generalized displaceme…
View article: Systematic Review and Meta‐Analysis of Peak Wall Stress and Peak Wall Rupture Index in Ruptured and Asymptomatic Intact Abdominal Aortic Aneurysms
Systematic Review and Meta‐Analysis of Peak Wall Stress and Peak Wall Rupture Index in Ruptured and Asymptomatic Intact Abdominal Aortic Aneurysms Open
Background Prior studies have suggested aortic peak wall stress (PWS) and peak wall rupture index (PWRI) can estimate the rupture risk of an abdominal aortic aneurysm (AAA), but whether these measurements have independent predictive abilit…
View article: Virtual Transcriptomics
Virtual Transcriptomics Open
Objective: Therapeutic advancements in atherosclerotic cardiovascular disease have improved prevention of ischemic stroke and myocardial infarction, but diagnostic methods for atherosclerotic plaque phenotyping to aid individualized therap…
View article: Comparison of peak wall stress and peak wall rupture index in ruptured and asymptomatic intact abdominal aortic aneurysms
Comparison of peak wall stress and peak wall rupture index in ruptured and asymptomatic intact abdominal aortic aneurysms Open
Background Previous studies have suggested that finite element analysis (FEA) can estimate the rupture risk of an abdominal aortic aneurysm (AAA); however, the value of biomechanical estimates over measurement of AAA diameter alone remains…
View article: Subject-specific FE models of the human femur predict fracture path and bone strength under single-leg-stance loading
Subject-specific FE models of the human femur predict fracture path and bone strength under single-leg-stance loading Open
Hip fractures are a major health problem with high socio-economic costs. Subject-specific finite element (FE) models have been suggested to improve the fracture risk assessment, as compared to clinical tools based on areal bone mineral den…
View article: Recombinant Spider Silk Forms Tough and Elastic Nanomembranes that are Protein‐Permeable and Support Cell Attachment and Growth
Recombinant Spider Silk Forms Tough and Elastic Nanomembranes that are Protein‐Permeable and Support Cell Attachment and Growth Open
Biologically compatible membranes are of high interest for several biological and medical applications. Tissue engineering, for example, would greatly benefit from ultrathin, yet easy‐to‐handle, biodegradable membranes that are permeable t…