David Harris
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View article: Barriers and enablers to referral of older adults to hearing care: a cross-sectional questionnaire study of Australian general practitioners
Barriers and enablers to referral of older adults to hearing care: a cross-sectional questionnaire study of Australian general practitioners Open
Background Acquired hearing loss has significant negative effects on quality of life, general health, maintenance of independence, and healthy aging. Despite this, rates of self-directed help seeking are low, as are referral rates from gen…
View article: Management of acute kidney disease as part of routine clinical care in low-resource settings: The International Society of Nephrology Kidney Care Network Project
Management of acute kidney disease as part of routine clinical care in low-resource settings: The International Society of Nephrology Kidney Care Network Project Open
Acute Kidney Disease (AKD) commonly affects disadvantaged populations in low-resourced areas with poor access to kidney care. Here, barriers to management include a lack of AKD education alongside an inability to measure serum creatinine (…
View article: COCHLEA: Longitudinal Cognitive Performance of Older Adults with Hearing Loss and Cochlear Implants at 4.5-Year Follow-Up
COCHLEA: Longitudinal Cognitive Performance of Older Adults with Hearing Loss and Cochlear Implants at 4.5-Year Follow-Up Open
Objectives: Hearing loss is highly prevalent in older adults and is independently associated with accelerated cognitive decline. Cochlear implants are usually the only effective treatment for people with severe–profound hearing loss, who h…
View article: Single step capture and assessment of multiple plasma extracellular vesicle biomarkers in Alzheimer’s disease detection
Single step capture and assessment of multiple plasma extracellular vesicle biomarkers in Alzheimer’s disease detection Open
Background Blood tests for Alzheimer’s disease (AD) that measure biomarkers could be useful as minimally‐invasive ways to give patients more and earlier access to screening. While some AD biomarkers can be detected in plasma, they need to …
View article: Identification and outcomes of acute kidney disease in patients presenting in Bolivia, Brazil, South Africa, and Nepal
Identification and outcomes of acute kidney disease in patients presenting in Bolivia, Brazil, South Africa, and Nepal Open
Background The International Society of Nephrology proposes an acute kidney disease (AKD) management strategy that includes a risk score to aid AKD identification in low- and low-middle-income countries (LLMICs). We investigated the perfor…
View article: ENHANCE: a comparative prospective longitudinal study of cognitive outcomes after 3 years of hearing aid use in older adults
ENHANCE: a comparative prospective longitudinal study of cognitive outcomes after 3 years of hearing aid use in older adults Open
Background With an aging population, the prevalence of hearing loss and dementia are increasing rapidly. Hearing loss is currently considered the largest potentially modifiable risk factor for dementia. The effect of hearing interventions …
View article: Cognitive function in older adults with hearing loss; outcomes for treated versus untreated groups at 3‐year follow‐up.
Cognitive function in older adults with hearing loss; outcomes for treated versus untreated groups at 3‐year follow‐up. Open
Background Hearing loss has been identified as the largest potentially modifiable risk factor for dementia and affects 50% adults aged 50‐64 years, and 70% aged 70 years and older. The quality of evidence the effect of hearing aid use on c…
View article: Semi-parametric single-index predictive regression models with cointegrated regressors
Semi-parametric single-index predictive regression models with cointegrated regressors Open
This paper considers the estimation of a semi-parametric single-index regression model that allows for nonlinear predictive relationships. This model is useful for predicting financial asset returns, whose observed behaviour resembles a st…
View article: Cognitive function and hearing loss: A longitudinal investigation of the effect of hearing aid use on cognitive performance in older adults
Cognitive function and hearing loss: A longitudinal investigation of the effect of hearing aid use on cognitive performance in older adults Open
Background Hearing loss is highly prevalent in older adults and has been identified as the largest single potentially modifiable risk factor for dementia. Although hearing aids are a successful treatment for hearing loss, it is unknown whe…
View article: Effects of Cleft Lip on Visual Scanning and Neural Processing of Infant Faces
Effects of Cleft Lip on Visual Scanning and Neural Processing of Infant Faces Open
Infant faces readily capture adult attention and elicit enhanced neural processing, likely due to their importance evolutionarily in facilitating bonds with caregivers. Facial malformations have been shown to impact early infant-caregiver …
View article: Reservoir properties and CO2 storage capacity of the Rose Run Sandstone (Lower Ordovician, Knox Group) in the Central Appalachian Basin, northeast Kentucky
Reservoir properties and CO2 storage capacity of the Rose Run Sandstone (Lower Ordovician, Knox Group) in the Central Appalachian Basin, northeast Kentucky Open
The Lower Ordovician Rose Run Sandstone is a potential CO 2 storage reservoir in the Central Appalachian Basin in northeast Kentucky where the Kentucky Geological Survey’s 1 Hanson Aggregates research well penetrated it at drill depths of …
View article: Optimal Probabilistic Forecasts for Counts
Optimal Probabilistic Forecasts for Counts Open
Optimal probabilistic forecasts of integer-valued random variables are derived. The optimality is achieved by estimating the forecast distribution nonparametrically over a given broad model class and proving asymptotic efficiency in that s…
View article: Conasauga Shale Research Consortium (CSRC) (Final Report)
Conasauga Shale Research Consortium (CSRC) (Final Report) Open
The objective of the Conasauga Shale Research Consortium (CSRC) project was to establish a field laboratory and utilize a horizontal well of opportunity to conduct a scientific study designed to advance the understanding of the petrophysic…
View article: Geomechanical properties will constrain CO2 injection into the lower Ordovician Rose Run sandstone deep saline reservoir, Appalachian Basin, Kentucky, USA
Geomechanical properties will constrain CO2 injection into the lower Ordovician Rose Run sandstone deep saline reservoir, Appalachian Basin, Kentucky, USA Open
The Kentucky Geological Survey (KGS) 1 Hanson Aggregates stratigraphic research well, Carter County, Kentucky, USA, was drilled to a total depth of 1474 m as a field-scale test of potential CO2 storage reservoir properties in the Central A…
View article: Improving communication between healthcare providers and pulmonary arterial hypertension patients: a survey of patient preferences
Improving communication between healthcare providers and pulmonary arterial hypertension patients: a survey of patient preferences Open
Effective communication within the patient–provider relationship is a key aspect of shared decision‐making and associated with several positive patient outcomes. Although previous studies suggest that patients’ and providers’ conceptualiza…
View article: Aspects of estimation and testing for cointegrated time series
Aspects of estimation and testing for cointegrated time series Open
The author retains copyright of this thesis. It must only be used for personal non-commercial research, education and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permissi…
View article: Hearing aid use and cognition in older adults: Can we delay decline or even improve cognitive function?
Hearing aid use and cognition in older adults: Can we delay decline or even improve cognitive function? Open
Background Hearing loss is associated with accelerated cognitive decline in older adults, and has been identified as a modifiable risk factor for dementia. Although hearing aids are a successful treatment for hearing loss, it is unknown wh…
View article: Level shift estimation in the presence of non-stationary volatility with an application to the unit root testing problem
Level shift estimation in the presence of non-stationary volatility with an application to the unit root testing problem Open
This paper focuses on the estimation of the location of level breaks in time series whose shocks display non-stationary volatility (permanent changes in unconditional volatility). We propose a new feasible weighted least squares (WLS) esti…
View article: The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?
The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function? Open
Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study (aged 62–82 years) were assessed before and 18 months after hear…
View article: Level Shift Estimation in the Presence of Non-stationary Volatility with an Application to the Unit Root Testing Problem
Level Shift Estimation in the Presence of Non-stationary Volatility with an Application to the Unit Root Testing Problem Open
This paper focuses on the estimation of the location of level breaks in time series whose shocks display non-stationary volatility (permanent changes in unconditional volatility). We propose a new feasible weighted least squares (WLS) esti…
View article: The Effect of Cochlear Implants on Cognitive Function in Older Adults: Initial Baseline and 18-Month Follow Up Results for a Prospective International Longitudinal Study
The Effect of Cochlear Implants on Cognitive Function in Older Adults: Initial Baseline and 18-Month Follow Up Results for a Prospective International Longitudinal Study Open
In older adults, hearing loss is independently associated with an increased rate of cognitive decline, and has been identified to be a modifiable risk factor for dementia. The mechanism underlying the cognitive decline associated with hear…
View article: SUN-147 TARGETING CD103+ DENDRITIC CELLS USING FLT3 INHIBITORS FOR TREATMENT OF KIDNEY DISEASE; RELEVANCE TO HUMAN KIDNEY DISEASE.
SUN-147 TARGETING CD103+ DENDRITIC CELLS USING FLT3 INHIBITORS FOR TREATMENT OF KIDNEY DISEASE; RELEVANCE TO HUMAN KIDNEY DISEASE. Open
Whereas CD103+ dendritic cells (DCs) were previously considered to be a minor DC subset in kidney disease, we and others have proven that they have a major role. Flt3 ligand is a growth factor essential for CD103+ DC development and surviv…
View article: DOES TECHNOLOGY USE PROTECT AGAINST COGNITIVE DECLINE? RESULTS FROM A RETROSPECTIVE COHORT STUDY
DOES TECHNOLOGY USE PROTECT AGAINST COGNITIVE DECLINE? RESULTS FROM A RETROSPECTIVE COHORT STUDY Open
Technology use among older adults is increasing rapidly. Cross-sectional studies have identified an association between technology use and better cognitive performance among older adults; however, to our knowledge, no studies have longitud…