Thomas W. Campi
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View article: Small molecule protein assembly modulators with pan-cancer therapeutic efficacy
Small molecule protein assembly modulators with pan-cancer therapeutic efficacy Open
Two structurally unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951, with antiviral activity in cell culture against Mpox virus (formerly known as monkeypox virus) and human immunodeficiency virus (HIV) respe…
View article: A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex
A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex Open
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative …
View article: Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy
Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy Open
Two structurally-unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951 with antiviral activity in cell culture against monkeypox virus (MPXV) and human immunodeficiency virus (HIV) respectively, were studied for…
View article: A Pan-Respiratory Antiviral Chemotype Targeting a Host Multi-Protein Complex
A Pan-Respiratory Antiviral Chemotype Targeting a Host Multi-Protein Complex Open
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative …