Thomas E. Carey
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View article: Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios Predict Improved Survival and Response to Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Larynx
Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios Predict Improved Survival and Response to Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Larynx Open
Background University of Michigan Cancer Center (UMCC) protocol 9520 treated stage III/IV locally advanced squamous cell carcinoma of the larynx (LASCCL) with cisplatin and 5‐fluorouracil to select for definitive therapy based on response.…
View article: Cervical Health in Systemic Lupus Erythematosus
Cervical Health in Systemic Lupus Erythematosus Open
Our high-risk cohort lacked knowledge about HPV-related diseases and were not employing strategies to reduce their risk with vaccination and condoms. This study highlights the need for cervical health education, increased monitoring, and i…
View article: Supplementary Table 1 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Supplementary Table 1 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Open
Supplementary Table 1 shows HNSCC patients' characteristics
View article: Supplemental Figure 2 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Figure 2 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
Differential mRNA expression of genes with copy number alterations. The relative mRNA expression of amplified genes was assessed across the all publically available next generation sequencing data where matched genome or exome-sequencing a…
View article: Table S1 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers
Table S1 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers Open
List of the human and HPV genomic locations for the 320 identified integration events.
View article: Supplemental Table 2 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Table 2 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
TaqMan quantitative RT-PCR assay primer and probe sequences.
View article: Supplemental Figure 2 from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3
Supplemental Figure 2 from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3 Open
Figure S2. A representative anal tumor section showing H&E staining and pS6, Ki67, p16 and OCT3 expression by IHC.
View article: Table S4 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers
Table S4 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers Open
GO terms and KEGG pathways enriched for genes differentially expressed between integration-positive and integration-negative HNC tumors.
View article: Supplemental Table 5 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Table 5 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
Summary of Integration Transcription Analysis in HPV16-Positive Tumors. (F), (R) = Forward or Reverse viral orientation in relation to the cellular gene. Bold text= Viral/cellular fusion transcript, Italicized text=Transcript spans integra…
View article: Supplemental Table 1 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Table 1 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
RT-PCR assay primer sequences and corresponding amplicon sizes.
View article: Table S1 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers
Table S1 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers Open
List of the human and HPV genomic locations for the 320 identified integration events.
View article: Data from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers
Data from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers Open
The incidence of human papillomavirus (HPV)–related oropharynx cancer has steadily increased over the past two decades and now represents a majority of oropharyngeal cancer cases. Integration of the HPV genome into the host genome is a com…
View article: Supplementary Table 2 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Supplementary Table 2 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Open
Supplementary Table 2 provides odds ratio per protein (CyTOF measurements)
View article: Data from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Data from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
High-risk HPV (hrHPV) is the leading etiologic factor in oropharyngeal cancer. HPV-positive oropharyngeal tumors generally respond well to therapy, with complete recovery in approximately 80% of patients. However, it remains unclear why so…
View article: Supplemental Figure 1 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Figure 1 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
Supplemental Figure 1. Representative DIPS PCR and transcript analysis electrophoretic gel images. M=100 bp ladder. Panel A. Representative Responsive Tumor DIPS PCR Gels. Panel B. Representative Recurrent Tumor DIPS PCR Gels. Panel C. Gel…
View article: Supplemental Table 1 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Table 1 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
RT-PCR assay primer sequences and corresponding amplicon sizes.
View article: Supplemental Materials and Methods; Supplementary Tables 5-14; Supplementary Figures 1-3. from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers
Supplemental Materials and Methods; Supplementary Tables 5-14; Supplementary Figures 1-3. from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers Open
Supplemental Methods, Tables S5-S14, and Figures S1-S3
View article: Supplemental Table 6 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Table 6 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
Supplemental Table 6. Summary of genomic aberrations to identified genes with integrated HPV. The Oncomine database was used to assess genomic aberrations in all publicly available HNSCC next generation sequencing data sets including (1, 2…
View article: Supplementary Table 1 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Supplementary Table 1 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Open
Supplementary Table 1 shows HNSCC patients' characteristics
View article: Data from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3
Data from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3 Open
Most squamous cell carcinomas of the head and neck (HNSCC) exhibit a persistent activation of the PI3K–mTOR signaling pathway. We have recently shown that metformin, an oral antidiabetic drug that is also used to treat lipodystrophy in HIV…
View article: Data from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Data from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Open
Radiotherapy (RT) along with surgery is the mainstay of treatment in head and neck squamous cell carcinoma (HNSCC). Radioresistance represents a major source of treatment failure, underlining the urgent necessity to explore and implement e…
View article: Supplemental Materials from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3
Supplemental Materials from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3 Open
Supplemental Materials and Methods: Reagents, cell lines, tissue culture. Legends to figure S1 and S2.
View article: Supplemental Table 3 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma
Supplemental Table 3 from Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma Open
DIPS primer sequences and predicted episome-only amplicon sizes.
View article: Supplementary Methods from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Supplementary Methods from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Open
Supplementary Methods
View article: Supplemental Figure 1 from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3
Supplemental Figure 1 from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3 Open
Figure S1. HNSCC cell lines CAL27, CAL33 and UMSCC47 were treated with the indicated concentrations of metformin or with rapamycin for colony formation assay (see Materials and Methods).
View article: Supplementary figures 1-6 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Supplementary figures 1-6 from Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Open
Supplementary figure 1 provides data concerning establishment of organotypic tissue cultures from freshly-resected HNSCC specimen Supplementary figure 2 shows analyses of MET expression and mutational status in a HNSCC cohort Supplementary…
View article: Data from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3
Data from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3 Open
Most squamous cell carcinomas of the head and neck (HNSCC) exhibit a persistent activation of the PI3K–mTOR signaling pathway. We have recently shown that metformin, an oral antidiabetic drug that is also used to treat lipodystrophy in HIV…
View article: Supplemental Materials and Methods; Supplementary Tables 5-14; Supplementary Figures 1-3. from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers
Supplemental Materials and Methods; Supplementary Tables 5-14; Supplementary Figures 1-3. from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers Open
Supplemental Methods, Tables S5-S14, and Figures S1-S3
View article: Supplemental Figure 2 from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3
Supplemental Figure 2 from Prevention of Tumor Growth Driven by <i>PIK3CA</i> and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3 Open
Figure S2. A representative anal tumor section showing H&E staining and pS6, Ki67, p16 and OCT3 expression by IHC.