Thomas Combriat
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View article: Aspects of zone-like identity and holotomographic tracking of human stem cell-derived liver sinusoidal endothelial cells
Aspects of zone-like identity and holotomographic tracking of human stem cell-derived liver sinusoidal endothelial cells Open
Introduction Liver sinusoidal endothelial cells (LSEC) are specialized endothelial cells with unique metabolic and barrier functions adapted to the needs of the liver sinusoid. LSECs are highly sensitive to their environment, and this frag…
View article: Bioimpedance and electrophysiology measurements of engineered heart tissues outside the culture medium
Bioimpedance and electrophysiology measurements of engineered heart tissues outside the culture medium Open
Engineered heart tissues (EHTs), composed of human stem cell-derived cardiomyocytes and fibroblasts, have emerged as promising tools for disease modeling and drug discovery due to their ability to replicate aspects of the function and stru…
View article: Cavitation dynamics in creeping flow
Cavitation dynamics in creeping flow Open
We investigate the heterogeneous cavitation phenomenon in water when a spherical surface is abruptly separated from a nearby flat substrate, at a distance of approximately 10 nm. By tracking the surface separation using Newton ring positio…
View article: The effects of TGF-β-induced activation and starvation of vitamin A and palmitic acid on human stem cell-derived hepatic stellate cells
The effects of TGF-β-induced activation and starvation of vitamin A and palmitic acid on human stem cell-derived hepatic stellate cells Open
Background Hepatic stellate cells (HSC) have numerous critical roles in liver function and homeostasis, while they are also known for their importance during liver injury and fibrosis. There is therefore a need for relevant in vitro human …
View article: Acoustic Wave‐Induced Stroboscopic Optical Mechanotyping of Adherent Cells
Acoustic Wave‐Induced Stroboscopic Optical Mechanotyping of Adherent Cells Open
In this study, a novel, high content technique using a cylindrical acoustic transducer, stroboscopic fast imaging, and homodyne detection to recover the mechanical properties (dynamic shear modulus) of living adherent cells at low ultrason…
View article: Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver
Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver Open
Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence. While the mechanisms leading to the onset and de…
View article: Acoustic wave-induced stroboscopic optical mechanotyping of adherent cells
Acoustic wave-induced stroboscopic optical mechanotyping of adherent cells Open
In this study, we present a novel, high content technique using an innovative cylindrical acoustic transducer, stroboscopic fast imaging and homodyne detection to recover the mechanical properties (dynamic shear modulus) of living adherent…
View article: Characterization of Mechanical and Cellular Effects of Rhythmic Vertical Vibrations on Adherent Cell Cultures
Characterization of Mechanical and Cellular Effects of Rhythmic Vertical Vibrations on Adherent Cell Cultures Open
This paper presents an innovative experimental setup that employs the principles of audio technology to subject adherent cells to rhythmic vertical vibrations. We employ a novel approach that combines three-axis acceleration measurements a…
View article: Music for Cells? A Systematic Review of Studies Investigating the Effects of Audible Sound Played Through Speaker-Based Systems on Cell Cultures
Music for Cells? A Systematic Review of Studies Investigating the Effects of Audible Sound Played Through Speaker-Based Systems on Cell Cultures Open
There have been several studies investigating whether musical sound can be used as cell stimuli in recent years. We systematically searched publications to get an overview of studies that have used audible sound played through speaker-base…
View article: Thermoplastic Elastomer (TPE)–Poly(Methyl Methacrylate) (PMMA) Hybrid Devices for Active Pumping PDMS-Free Organ-on-a-Chip Systems
Thermoplastic Elastomer (TPE)–Poly(Methyl Methacrylate) (PMMA) Hybrid Devices for Active Pumping PDMS-Free Organ-on-a-Chip Systems Open
Polydimethylsiloxane (PDMS) has been used in microfluidic systems for years, as it can be easily structured and its flexibility makes it easy to integrate actuators including pneumatic pumps. In addition, the good optical properties of the…
View article: Music for cells? A systematic review of studies investigating the effects of audible sound played through speaker-based systems to cell cultures
Music for cells? A systematic review of studies investigating the effects of audible sound played through speaker-based systems to cell cultures Open
There have been several studies investigating whether musical sound can be used as cell stimuli in recent years. We systematically searched publications to get an overview of studies that have used audible sound played through speaker-base…
View article: Acoustic interaction between 3D fabricated cubic bubbles
Acoustic interaction between 3D fabricated cubic bubbles Open
ĂSpherical bubbles are notoriously difficult to hold in specific arrangements in water and tend to dissolve over time. Here, using stereolithographic printing, we built an assembly of millimetric cubic frames overcoming these limitations. …
View article: Acoustic interaction between 3D-fabricated cubic bubbles
Acoustic interaction between 3D-fabricated cubic bubbles Open
Spherical bubbles are difficult to hold in specific arrangements and tend to dissolve in water over time. Using 3D-fabricated cubic frames we trap and stabilize bubbles that still oscillate under acoustic excitation.
View article: Etude d'une assemblée de bulles microfluidiques excitées par une onde ultrasonore : transmission acoustique et phénomène de streaming
Etude d'une assemblée de bulles microfluidiques excitées par une onde ultrasonore : transmission acoustique et phénomène de streaming Open
Because of the important compressibility of gas bubbles in water, inducing a very low resonance frequency, one can find interest in studying bubbles from an acoustic and a fluid mechanics point of view. Using microfluidics techniques in or…
View article: Trapping and exclusion zones in complex streaming patterns around a large assembly of microfluidic bubbles under ultrasound
Trapping and exclusion zones in complex streaming patterns around a large assembly of microfluidic bubbles under ultrasound Open
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View article: Sound and Vision: Visualization of music with a soap film, and the physics behind it
Sound and Vision: Visualization of music with a soap film, and the physics behind it Open
A vertical soap film, freely suspended at the end of a tube, is vibrated by a sound wave that propagates in the tube. If the sound wave is a piece of music, the soap film comes alive: colours, due to the soap film iridescences, swirl, spli…
View article: Bubble-based acoustic micropropulsors: active surfaces and mixers
Bubble-based acoustic micropropulsors: active surfaces and mixers Open
Bubble-based acoustic propulsors are fabricated with 3D micro-printing. They generate collective flows used for fast and efficient mixing in microchannels.
View article: Acoustic streaming produced by a cylindrical bubble undergoing volume and translational oscillations in a microfluidic channel
Acoustic streaming produced by a cylindrical bubble undergoing volume and translational oscillations in a microfluidic channel Open
A theoretical model is developed for acoustic streaming generated by a cylindrical bubble confined in a fluid channel between two planar elastic walls. The bubble is assumed to undergo volume and translational oscillations. The volume osci…
View article: Effect of surface waves on the secondary Bjerknes force experienced by bubbles in a microfluidic channel
Effect of surface waves on the secondary Bjerknes force experienced by bubbles in a microfluidic channel Open
An analytical expression is derived for the secondary Bjerknes force experienced by two cylindrical bubbles in a microfluidic channel with planar elastic walls. The derived expression takes into account that the bubbles generate two types …
View article: Interactions enhance the acoustic streaming around flattened microfluidic bubbles
Interactions enhance the acoustic streaming around flattened microfluidic bubbles Open
The vibration of bubbles can produce intense microstreaming when excited by ultrasound near resonance. In order to study freely oscillating bubbles in steady conditions, we have confined bubbles between the two walls of a silicone microcha…
View article: Inhibition of wave-driven two-dimensional turbulence by viscoelastic films of proteins
Inhibition of wave-driven two-dimensional turbulence by viscoelastic films of proteins Open
To model waves, surface flows, and particle dispersion at the air-water interface one needs to know the essential mechanisms affecting the fluid motion at the surface. We show that a thin film (less than 10-nm thick) of adsorbed protein dr…