Thomas Comptdaer
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View article: Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin
Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin Open
Introduction RNA expression is modulated by tau. We used two mouse models, THY-Tau22 mice, which express pro-aggregation tau, and TauKO mice, which are null for tau, to improve our understanding of tau-altered mRNA expression in brain. Met…
View article: Cell redistribution of <scp>G</scp> quadruplex‐structured <scp>DNA</scp> is associated with morphological changes of nuclei and nucleoli in neurons during tau pathology progression
Cell redistribution of <span>G</span> quadruplex‐structured <span>DNA</span> is associated with morphological changes of nuclei and nucleoli in neurons during tau pathology progression Open
While the double helical structure has long been its iconic representation, DNA is structurally dynamic and can adopt alternative secondary configurations. Specifically, guanine‐rich DNA sequences can fold in guanine quadruplexes (G4) stru…
View article: Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice
Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice Open
Alzheimer’s disease (AD) is a progressive brain disorder characterized by extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein and neuroinflammation. Previous research has sh…
View article: Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents
Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents Open
Recent reports suggested a role for microtubules in double-strand-DNA break repair. We herein investigated the role of the microtubule-associated protein Tau in radio- and chemotherapy. Noticeably, a lowered expression of Tau in breast can…
View article: Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response Open
Background Zika virus (ZIKV) infection at postnatal or adult age can lead to neurological disorders associated with cognitive defects. Yet, how mature neurons respond to ZIKV remains substantially unexplored. Methods The impact of ZIKV inf…
View article: Tau Stabilizes Chromatin Compaction
Tau Stabilizes Chromatin Compaction Open
An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusiv…
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients Open
Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson's disease (PD), and orally bioavailable, brain penetrant and highly potent LRRK2 kinase inhibitors are in early stages of clinical testin…
View article: Transcriptomic signatures of brain regional vulnerability to Parkinson’s disease
Transcriptomic signatures of brain regional vulnerability to Parkinson’s disease Open
The molecular mechanisms underlying the caudal-to-rostral progression of Lewy body pathology in Parkinson’s disease (PD) remain poorly understood. Here, we aimed to unravel transcriptomic signatures across brain regions involved in Braak L…
View article: Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice
Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice Open
Parkinson's disease is a progressive neurodegenerative disorder characterized by loss of dopaminergic neurons, pathological accumulation of alpha-synuclein and motor symptoms, but also by non-motor symptoms. Metabolic abnormalities includi…