Explanipedia

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk Open

Amanda Dobbyn, Douglas M. Ruderfer, Gabriel E. Hoffman, Antonio F. Pardiñas, Veera M. Rajagopal , et al. · 2025

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk Open

Laura M. Huckins, Amanda Dobbyn, Douglas M. Ruderfer, Gabriel E. Hoffman, Weiqing Wang , et al. · 2025

Genomics yields biological and phenotypic insights into bipolar disorder Open

Kevin S. O‘Connell, Maria Koromina, Tracey van der Veen, Toni Boltz, Friederike S. David , et al. · 2025

Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology Open

Simone Montalbano, Morten Dybdahl Krebs, Anders Rosengren, Morteza Vaez, Kajsa-Lotta Georgii Hellberg , et al. · 2024

The NRXN1 locus is a hotspot for non-recurrent copy number variants and exon-disrupting NRXN1 deletions have been associated with increased risk of neurodevelopmental disorders in case-control studies. However, corresponding population-bas…

Polygenic liabilities and treatment trajectories in early-onset depression: a Danish register-based study Open

Jessica Mundy, Alisha S. M. Hall, Jette Steinbach, Clara Albiñana, Esben Agerbo , et al. · 2024

Background The clinical course of major depressive disorder (MDD) is heterogeneous, and early-onset MDD often has a more severe and complex clinical course. Our goal was to determine whether polygenic scores (PGSs) for psychiatric disorder…

Sex differences in shared genetic determinants between severe mental disorders and metabolic traits Open

Claudia Pisanu, Donatella Congiu, Anna Maria Meloni, Pasquale Paribello, Giovanni Severino , et al. · 2024

Population-Based Risk of Psychiatric Disorders Associated With Recurrent Copy Number Variants Open

Morteza Vaez, Simone Montalbano, Xabier Calle Sánchez, Kajsa-Lotta Georgii Hellberg, Saeid Rasekhi Dehkordi , et al. · 2024

Importance Recurrent copy number variants (rCNVs) have been associated with increased risk of psychiatric disorders in case-control studies, but their population-level impact is unknown. Objective To provide unbiased population-based estim…

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease Open

Jacob Bergstedt, Joëlle A. Pasman, Ziyan Ma, Arvid Harder, Shuyang Yao , et al. · 2024

Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide associatio…

Phenotypic and ancestry-related assortative mating in autism Open

Jing Zhang, J. Dylan Weissenkampen, Rachel L. Kember, David M. Hougaard, Jonas Bybjerg‐Grauholm , et al. · 2024

Genome-wide association study identifies new loci associated with OCD Open

Nora I. Strom, Matthew Halvorsen, Chao Tian, Christian Rück, Gerd Kvale , et al. · 2024

To date, four genome-wide association studies (GWAS) of obsessive-compulsive disorder (OCD) have been published, reporting a high single-nucleotide polymorphism (SNP)-heritability of 28% but finding only one significant SNP. A sub-stantial…

Genomics yields biological and phenotypic insights into bipolar disorder Open

Kevin S. O’Connell, Maria Koromina, Tracey van der Veen, Toni Boltz, Friederike S. David , et al. · 2023

Bipolar disorder (BD) is a leading contributor to the global burden of disease 1 . Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown 2 . We analysed data from participants of European, E…

Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease Open

Jacob Bergstedt, Joëlle A. Pasman, Ziyan Ma, Arvid Harder, Shuyang Yao , et al. · 2023

Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Using genomic data, this study elucidates biological mechanisms, key risk factors, and causal pathways underl…

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses Open

Thomas D. Als, Mitja Kurki, Jakob Grove, Georgios Voloudakis, Karen Therrien , et al. · 2023

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy Open

Hanna M. Ollila, Eilon Sharon, Ling Lin, Nasa Sinnott-Armstrong, Aditya Ambati , et al. · 2023

Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains Open

Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond K. Walters, Karen Therrien , et al. · 2023

Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome Open

Pritesh Jain, Tyne W. Miller‐Fleming, Apostolia Topaloudi, Dongmei Yu, Petros Drineas , et al. · 2023

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains Open

Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond K. Walters, Karen Therrien , et al. · 2023

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity Open

Veera M. Rajagopal, Andrea Ganna, Jonathan R. I. Coleman, Andrea G. Allegrini, Georgios Voloudakis , et al. · 2023

FarGen: Elucidating the distribution of coding variants in the isolated population of the Faroe Islands Open

Ólavur Mortensen, Elisabet Thomsen, Leivur N. Lydersen, Katrin D. Apol, Pál Weihe , et al. · 2022

Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p Open

Daniel J. Weiner, Emi Ling, Serkan Erdin, Derek J.C. Tai, Rachita Yadav , et al. · 2022

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups Open

Manuel Mattheisen, Jakob Grove, Thomas D. Als, Joanna Martin, Georgios Voloudakis , et al. · 2022

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities Open

Thomas D. Als, Mitja Kurki, Jakob Grove, Georgios Voloudakis, Karen Therrien , et al. · 2022

Major depression (MD) is a common mental disorder and a leading cause of disability worldwide. We conducted a GWAS meta-analysis of more than 1.3 million individuals, including 371,184 with MD, identifying 243 risk loci. Sixty-four loci ar…

Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder Open

Veera M. Rajagopal, Jinjie Duan, Laura Vilar‐Ribó, Jakob Grove, Tetyana Zayats , et al. · 2022

FarGen: Elucidating the distribution of coding variants in the isolated population of the Faroe Islands Open

Noomi O. Gregersen, Ólavur Mortensen, Elisabet Thomsen, Leivur Lydersen, Katrin Apol , et al. · 2022

Here we present results from FarGen Phase I exomes. This dataset is based on the FarGen cohort, which consists of 1,541 individuals from the isolated population of the Faroe Islands. The purpose of this cohort is to serve as a reference ca…

Mapping genomic loci implicates genes and synaptic biology in schizophrenia Open

Vassily Trubetskoy, Antonio F. Pardiñas, Ting Qi, Georgia Panagiotaropoulou, Swapnil Awasthi , et al. · 2022

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains Open

Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond K. Walters, Karen Therrien , et al. · 2022

Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood psychiatric disorder, with a major genetic component. Here we present a GWAS meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We id…

Atlantic herring (Clupea harengus) population structure in the Northeast Atlantic Ocean Open

Sunnvør í Kongsstovu, Svein‐Ole Mikalsen, Eydna í Homrum, Jan Arge Jacobsen, Thomas D. Als , et al. · 2022

Genome-wide by Environment Interaction Study of Stressful Life Events and Hospital-Treated Depression in the iPSYCH2012 Sample Open

Nis P. Suppli, Klaus Kaae Andersen, Esben Agerbo, Veera M. Rajagopal, Vivek Appadurai , et al. · 2021

In this large, population-based GWEIS, we did not find any replicable hits for interaction. Future gene-by-stress research in depression should focus on establishing even larger collaborative GWEISs to attain sufficient power.

Genome-wide by environment interaction study of stressful life events and hospital-treated depression in the iPSYCH2012 sample Open

Nis P. Suppli, Klaus Kaae Andersen, Esben Agerbo, Veera M. Rajagopal, Vivek Appadurai , et al. · 2021

Researchers have long investigated a hypothesized interaction between genetic risk and stressful life events in the etiology of depression, but studies on the topic have yielded inconsistent results. We conducted a genome-wide environment …

Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis Open

Nora I. Strom, Jakob Grove, Sandra Meier, Marie Bækvad‐Hansen, Judith Becker Nissen , et al. · 2021

Among patients with obsessive-compulsive disorder (OCD), 65–85% manifest another psychiatric disorder concomitantly or at some other time point during their life. OCD is highly heritable, as are many of its comorbidities. A possible geneti…

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