Thomas Distler
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View article: 3D bioprinting of mouse pre-osteoblasts and human MSCs using bioinks consisting of gelatin and decellularized bone particles
3D bioprinting of mouse pre-osteoblasts and human MSCs using bioinks consisting of gelatin and decellularized bone particles Open
One of the key challenges in biofabrication applications is to obtain bioinks that provide a balance between printability, shape fidelity, cell viability, and tissue maturation. Decellularization methods allow the extraction of natural ext…
View article: 3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering
3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering Open
Bone healing is a complex process orchestrated by various factors, such as mechanical, chemical and electrical cues. Creating synthetic biomaterials that combine several of these factors leading to tailored and controlled tissue regenerati…
View article: Fish scale containing alginate dialdehyde-gelatin bioink for bone tissue engineering
Fish scale containing alginate dialdehyde-gelatin bioink for bone tissue engineering Open
The development of biomaterial inks suitable for biofabrication and mimicking the physicochemical properties of the extracellular matrix is essential for the application of bioprinting technology in tissue engineering (TE). The use of anim…
View article: Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials
Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials Open
Numerical simulations are a valuable tool to understand which processes during mechanical stimulations of hydrogels for cartilage replacement influence the behavior of chondrocytes and contribute to the success or failure of these material…
View article: Biodegradable Polylactide Supraparticle Powders with Functional Additives for Biomedical Additive Manufacturing
Biodegradable Polylactide Supraparticle Powders with Functional Additives for Biomedical Additive Manufacturing Open
Additive manufacturing, in particular powder bed‐based fabrication processes hold promise to revolutionize biomedical engineering for the ability to provide customized, functional implants, for example as bone replacement materials. Howeve…
View article: Hyperelastic parameter identification of human articular cartilage and substitute materials
Hyperelastic parameter identification of human articular cartilage and substitute materials Open
Numerical simulations are a valuable tool in the field of tissue engineering for cartilage repair and can help to understand which mechanical properties affect the behavior of chondrocytes and contribute to the success or failure of surrog…
View article: 3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study
3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study Open
Three-dimensional (3D) printing technology enables the design of personalized scaffolds with tunable pore size and composition. Combining decellularization and 3D printing techniques provides the opportunity to fabricate scaffolds with hig…
View article: 3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering
3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering Open
Bioprinting has seen significant progress in recent years for the fabrication of bionic tissues with high complexity. However, it remains challenging to develop cell‐laden bioinks exhibiting superior physiochemical properties and bio‐funct…
View article: Human Induced Pluripotent Stem Cell‐Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties
Human Induced Pluripotent Stem Cell‐Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties Open
Stable and predictive neural cell culture models are a necessary premise for many research fields. However, conventional 2D models lack 3D cell‐material/‐cell interactions and hence do not reflect the complexity of the in vivo situation pr…
View article: Propagation‐Based Phase Contrast Computed Tomography as a Suitable Tool for the Characterization of Spatial 3D Cell Distribution in Biomaterials
Propagation‐Based Phase Contrast Computed Tomography as a Suitable Tool for the Characterization of Spatial 3D Cell Distribution in Biomaterials Open
The 3D structural investigation of soft tissue samples under near physiological conditions is challenging as most established techniques require embedding, staining, or cutting samples. Such manipulations can induce artifacts or result in …
View article: Electrically Conductive and 3D‐Printable Oxidized Alginate‐Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering
Electrically Conductive and 3D‐Printable Oxidized Alginate‐Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering Open
Electroactive hydrogels can be used to influence cell response and maturation by electrical stimulation. However, hydrogel formulations which are 3D printable, electroactive, cytocompatible, and allow cell adhesion, remain a challenge in t…
View article: Neuronal Differentiation from Induced Pluripotent Stem Cell-Derived Neurospheres by the Application of Oxidized Alginate-Gelatin-Laminin Hydrogels
Neuronal Differentiation from Induced Pluripotent Stem Cell-Derived Neurospheres by the Application of Oxidized Alginate-Gelatin-Laminin Hydrogels Open
Biodegradable hydrogels that promote stem cell differentiation into neurons in three dimensions (3D) are highly desired in biomedical research to study drug neurotoxicity or to yield cell-containing biomaterials for neuronal tissue repair.…
View article: Identification of mechanical models and parameters for alginate‐based hydrogels as proxy materials for brain tissue
Identification of mechanical models and parameters for alginate‐based hydrogels as proxy materials for brain tissue Open
Due to their qualitatively similar mechanical behavior to brain tissue, the present study focuses on the modeling and identification of material parameters for alginate‐gelatine hydrogels. A generalized Maxwell model is used to describe it…
View article: Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels
Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels Open
Cell containing hydrogels represent a key strategy in tissue engineering. Complex mechanical analyses show that the stiffness significantly drops for high concentrations of cells and microgel-bead fillers in non-fibrous alginate-based hydr…
View article: Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair
Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair Open
The mechanical behavior of cartilage tissue plays a crucial role in physiological mechanotransduction processes of chondrocytes and pathological changes like osteoarthritis. Therefore, intensive research activities focus on the identificat…
View article: Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels towards Cartilage Tissue Engineering by Electrical Stimulation
Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels towards Cartilage Tissue Engineering by Electrical Stimulation Open
Cartilage regeneration is a clinical challenge. In recent years, hydrogels have emerged as implantable scaffolds in cartilage tissue engineering. Similarly, electrical stimulation has been employed to improve matrix synthesis of cartilage …
View article: Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization
Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization Open
Critical size bone defects are regularly treated by auto- and allograft transplantation. However, such treatments require to harvest bone from patient donor sites, with often limited tissue availability or risk of donor site morbidity. Not…
View article: 3D printed oxidized alginate-gelatin bioink provides guidance for C2C12 muscle precursor cell orientation and differentiation via shear stress during bioprinting
3D printed oxidized alginate-gelatin bioink provides guidance for C2C12 muscle precursor cell orientation and differentiation via shear stress during bioprinting Open
Biofabrication can be a tool to three-dimensionally (3D) print muscle cells embedded inside hydrogel biomaterials, ultimately aiming to mimic the complexity of the native muscle tissue and to create in-vitro muscle analogues for advanced r…
View article: Sintering behavior of 3D printed barium titanate composite scaffolds for bone repair
Sintering behavior of 3D printed barium titanate composite scaffolds for bone repair Open
Additive manufacturing of novel biomaterials with additional stimulating functions represents a promising strategy for bone repair. In this study, a systematic investigation of the necessary thermal post-treatment of 3D printed barium tita…
View article: 3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering
3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering Open
The prevalence of large bone defects is still a major problem in surgical clinics. It is, thus, not a surprise that bone-related research, especially in the field of bone tissue engineering, is a major issue in medical research. Researcher…
View article: Development of 3D Biofabricated Cell Laden Hydrogel Vessels and a Low‐Cost Desktop Printed Perfusion Chamber for In Vitro Vessel Maturation
Development of 3D Biofabricated Cell Laden Hydrogel Vessels and a Low‐Cost Desktop Printed Perfusion Chamber for In Vitro Vessel Maturation Open
The vascular system represents the key supply chain for nutrients and oxygen inside the human body. Engineered solutions to produce sophisticated alternatives for autologous or artificial vascular implants to sustainably replace diseased v…
View article: 3D printing of smart materials for bone regeneration
3D printing of smart materials for bone regeneration Open
Additive manufacturing (AM) of medical implants continues to receive broad attention in regenerative medicine. The application of smart materials combined with AM represents a new approach to enhance the functionality of modern implants to…