Dong Won Kim
YOU?
Author Swipe
View article: Paired DNA/RNA testing uncovers a deep intronic PTEN pathogenic variant associated with clinical Cowden Syndrome: a case report
Paired DNA/RNA testing uncovers a deep intronic PTEN pathogenic variant associated with clinical Cowden Syndrome: a case report Open
Identification of a deep intronic PTEN pathogenic variant, which was not detected by standard DNA-targeted panel sequencing but was uncovered by targeted PTEN RNA sequencing using CaptureSeq technology, illustrates the added value of concu…
View article: Sleep pressure is differentially regulated by molecularly distinct subtypes of Lhx6-positive and Lhx6-negative neurons of the zona incerta
Sleep pressure is differentially regulated by molecularly distinct subtypes of Lhx6-positive and Lhx6-negative neurons of the zona incerta Open
Sleep pressure, the accumulating drive towards sleep during wakefulness, is shaped by Lhx6-positive GABAergic neurons in the zona incerta (ZI). Here, we show that these neurons are broadly activated both by spontaneous and experimentally-e…
View article: Decoding gene networks controlling hypothalamic and prethalamic neuron development
Decoding gene networks controlling hypothalamic and prethalamic neuron development Open
The hypothalamus and prethalamus regulate diverse physiological and behavioral processes, yet the gene regulatory networks guiding their development remain poorly defined. Using single-cell RNA and ATAC sequencing, we profile over 660,000 …
View article: Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development
Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development Open
Summary Neuronal subtypes derived from the embryonic hypothalamus and prethalamus regulate many essential physiological processes, yet the gene regulatory networks controlling their development remain poorly understood. Using single-cell R…
View article: Resolving forebrain developmental organisation by analysis of differential growth patterns
Resolving forebrain developmental organisation by analysis of differential growth patterns Open
The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombination lineage tracing, and built a 4D m…
View article: Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathway
Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathway Open
Despite recent advances in the treatment of thyroid eye disease thyroid-related eye disease (TED), marked gaps remain in our understanding of the underlying molecular mechanisms, particularly concerning the insulin-like growth factor-1 rec…
View article: Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway
Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway Open
Despite recent advances in the treatment of thyroid eye disease (TED), significant gaps remain in our understanding of the underlying molecular mechanisms, particularly concerning the insulin-like growth factor-1 receptor (IGF-1R) pathway.…
View article: An Amygdalar Oscillator Coordinates Cellular and Behavioral Rhythms
An Amygdalar Oscillator Coordinates Cellular and Behavioral Rhythms Open
SUMMARY Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN), in concert with local clocks throughout the body. While many brain regions exhibit cycling clock gene expression, the identity of a discrete ext…
View article: A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus
A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus Open
Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila , the clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks and cyclically regulates sleep a…
View article: Calcium-permeable AMPA receptors govern PV neuron feature selectivity
Calcium-permeable AMPA receptors govern PV neuron feature selectivity Open
The brain helps us survive by forming internal representations of the external world 1,2 . Excitatory cortical neurons are often precisely tuned to specific external stimuli 3,4 . However, inhibitory neurons, such as parvalbumin-positive (…
View article: Papillary Histiocytic and Mesothelial Hyperplasia of the Ovary Related to a Huge Uterus: A Case Report
Papillary Histiocytic and Mesothelial Hyperplasia of the Ovary Related to a Huge Uterus: A Case Report Open
Nodular histiocytic/mesothelial hyperplasia (NHMH) is a very rare condition. It is generally thought to be associated with repeated mechanical or chemical stimulation. This study reported NHMH with papillary growth pattern in the ovary fol…
View article: A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus
A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus Open
The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its fundamental role, the cells and signalling pathways that specify this unique region of the central nervous system in embryogenesis are poorly characte…
View article: Author response: A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus
Author response: A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The tuberal hypothalam…
View article: Synthetic maize centromeres transmit chromosomes across generations
Synthetic maize centromeres transmit chromosomes across generations Open
Centromeres are long, often repetitive regions of genomes that bind kinetochore proteins and ensure normal chromosome segregation. Engineering centromeres that function in vivo has proven to be difficult. Here we describe a LexA-CENH3 teth…
View article: A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus
A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus Open
The tuberal hypothalamus houses several major hypothalamic nuclei, dozens of transcriptionally distinct cell types, and clinically relevant cell populations implicated in obesity and related metabolic disorders. Building on recent advances…
View article: SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis
SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis Open
Pro-opiomelanocortin (POMC)-expressing neurons in the hypothalamic arcuate nucleus (ARC) play key roles in feeding and energy homoeostasis, hence their development is of great research interest. As the process of neurogenesis is accompanie…
View article: Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes Open
Background Amongst risk alleles associated with late-onset Alzheimer’s disease (AD), those that converged on the regulation of microglia activity have emerged as central to disease progression. Yet, how canonical amyloid-β (Aβ) and tau pat…
View article: Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes
Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes Open
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche. NrCAM is strongly expresse…
View article: Author Correction: The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
Author Correction: The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development Open
The original version of this Article contained an error in 'Data analysis', which incorrectly read: 'For analysis of hypothalamic patterning and generation of the developmental database HyDD (Hypothalamus Developmental Database), the E11, …
View article: The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes
The neural cell adhesion molecule NrCAM regulates development of hypothalamic tanycytes Open
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche. NrCAM is strongly expresse…
View article: Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina
Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina Open
Gene regulatory networks (GRNs), consisting of transcription factors and their target sites, control neurogenesis and cell-fate specification in the developing central nervous system. In this study, we use integrated single-cell RNA and si…
View article: Amyloid-beta and tau pathologies are both necessary to induce novel stage-specific microglia subtypes during Alzheimer’s disease progression
Amyloid-beta and tau pathologies are both necessary to induce novel stage-specific microglia subtypes during Alzheimer’s disease progression Open
It is unknown whether specific microglia are selectively induced by amyloid-β (Aβ), tau pathologies, or both in combination. To address this, we use single-cell RNA-sequencing to profile mice bearing both Aβ and tau pathologies during Alzh…