Thomas D. Dyer
YOU?
Author Swipe
View article: Editorial: The Heart of Learning: Embracing Change in Education With Empathy and Innovation
Editorial: The Heart of Learning: Embracing Change in Education With Empathy and Innovation Open
The educational landscape is experiencing a period of transformation, shaped by advancements in technology, shifts in student demographics, and the ever-growing emphasis on well-being and inclusivity. As we navigate these changes, it is es…
View article: Editorial: Reflecting on Culturally Responsive Teaching and Learning, Supporting Indigenous and International Learners
Editorial: Reflecting on Culturally Responsive Teaching and Learning, Supporting Indigenous and International Learners Open
As we approach the halfway point of 2023, it is time to reflect on the progress that has been made in the field of scholarly engagement. In recent years, there has been a growing recognition of the importance of engaging with the public in…
View article: You Can't Have It All: Faculty and Student Priorities in the Online Classroom
You Can't Have It All: Faculty and Student Priorities in the Online Classroom Open
While potential teaching activities in the online classroom are unlimited, an instructor’s teaching time is not. As such, it is essential that online instructors prioritize limited time to instructional strategies that have the greatest im…
View article: Motivating and Engaging Students: Reflections on Gamifying Online Courses Through a Digital Badging Program
Motivating and Engaging Students: Reflections on Gamifying Online Courses Through a Digital Badging Program Open
The purpose of this reflective critique was to explore faculty approaches to engage and motivate students while promoting community and building skills in the online classroom. One of the primary benefits of this critique is to bring focus…
View article: The association of genetic variants of type 2 diabetes with kidney function
The association of genetic variants of type 2 diabetes with kidney function Open
Type 2 diabetes is highly prevalent and is the major cause of progressive chronic kidney disease in American Indians. Genome wide association studies identified several loci associated with diabetes but their impact on susceptibility to di…
View article: Social- and Behavioral-Specific Genetic Effects on Blood Pressure Traits: The Strong Heart Family Study
Social- and Behavioral-Specific Genetic Effects on Blood Pressure Traits: The Strong Heart Family Study Open
Population studies have demonstrated an important role of social, behavioral, and environmental factors in blood pressure levels. Accounting for the genetic interaction of these factors may help to identify common blood pressure susceptibi…
View article: Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation Open
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of b…
View article: Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives
Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives Open
Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect …
View article: Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits
Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits Open
In order to identify regulatory genes, we determined the heritability of gene transcripts, performed linkage analysis to identify quantitative trait loci (QTLs), and evaluated the evidence for shared genetic effects among transcripts with …
View article: A QTL on chromosome 3q23 influences processing speed in humans
A QTL on chromosome 3q23 influences processing speed in humans Open
Processing speed is a psychological construct that refers to the speed with which an individual can perform any cognitive operation. Processing speed correlates strongly with general cognitive ability, declines sharply with age and is impa…
View article: PROXIMITY IN THE ONLINE CLASSROOM:ENGAGEMENT, RELATIONSHIPS, AND PERSONALIZATION
PROXIMITY IN THE ONLINE CLASSROOM:ENGAGEMENT, RELATIONSHIPS, AND PERSONALIZATION Open
For those who have taught in the traditional classroom at any level, proximity is understood as a best practice in managing classroom behaviors.The farther away the teacher is from the student the is true, the closer the teacher is to the …
View article: Neurodegenerative disease biomarkers Aβ<sub>1–40</sub>, Aβ<sub>1–42</sub>, tau, and p‐tau<sub>181</sub> in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy
Neurodegenerative disease biomarkers Aβ<sub>1–40</sub>, Aβ<sub>1–42</sub>, tau, and p‐tau<sub>181</sub> in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy Open
Background The Caribbean vervet monkey ( Chlorocebus aethiops sabaeus ) is a potentially valuable animal model of neurodegenerative disease. However, the trajectory of aging in vervets and its relationship to human disease is incompletely …
View article: Inferring identical by descent sharing of sample ancestors promotes high resolution relative detection
Inferring identical by descent sharing of sample ancestors promotes high resolution relative detection Open
As genetic datasets increase in size, the fraction of samples with one or more close relatives grows rapidly, resulting in sets of mutually related individuals. We present DRUID—Deep Relatedness Utilizing Identity by Descent—a method that …
View article: Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees Open
Significance Contributions of rare variants to common and complex traits such as type 2 diabetes (T2D) are difficult to measure. This paper describes our results from deep whole-genome analysis of large Mexican-American pedigrees to unders…
View article: Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus)
Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus) Open
As in humans, growth patterns in vervets have a significant impact on adult obesity and are largely under genetic control with some evidence for maternal and dietary programming. These results largely mirror findings from human research, b…
View article: Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives
Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives Open
Relatedness inference is an essential component of many genetic analyses and popular in consumer genetic testing. Ramstetter et al. evaluate twelve..... Inferring relatedness from genomic data is an essential component of genetic associati…
View article: TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis
TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis Open
We show, for the first time, that TRAK2 is a novel regulator of LXR-mediated ABCA1 expression, cholesterol efflux, and HDL biogenesis. TRAK2 may therefore be an important target in the development of anti-atherosclerotic therapies.
View article: A performance assessment of relatedness inference methods using genome-wide data from thousands of relatives
A performance assessment of relatedness inference methods using genome-wide data from thousands of relatives Open
Inferring relatedness from genomic data is an essential component of genetic association studies, population genetics, forensics, and genealogy. While numerous methods exist for inferring relatedness, thorough evaluation of these approache…
View article: Additional file 5: Table S4. of Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families
Additional file 5: Table S4. of Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families Open
Environmental correlation of plasma lipid species with T2D-related traits. (XLSX 54Â kb)
View article: Additional file 4: Table S3. of Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families
Additional file 4: Table S3. of Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families Open
Genetic correlation of plasma lipid species with T2D-related traits. (XLSX 42Â kb)
View article: Erratum: Linkage of Type 2 Diabetes on Chromosome 9p24 in Mexican Americans: Additional Evidence from the Veterans Administration Genetic Epidemiology Study (VAGES)
Erratum: Linkage of Type 2 Diabetes on Chromosome 9p24 in Mexican Americans: Additional Evidence from the Veterans Administration Genetic Epidemiology Study (VAGES) Open
Objective: Type 2 diabetes (T2DM) is a complex metabolic disease and is more prevalent in certain ethnic groups such as the Mexican Americans. The goal of our study was to perform a genome-wide linkage (GWL) analysis to localize T2DM susce…
View article: Additional file 3: Table S2. of Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families
Additional file 3: Table S2. of Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families Open
Results of censored normal regression. (XLSX 35Â kb)