Thomas E. Finger
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View article: Taste dysfunction in Long COVID
Taste dysfunction in Long COVID Open
Persistent taste dysfunction is frequently reported in individuals with post-acute sequelae of infection by SARS-CoV-2 (Long COVID). The mechanisms and pathological correlates underlying this taste dysfunction are unknown. This study inves…
View article: Death in the Taste Bud: Engulfment of Dying Taste Receptor Cells by Glial‐Like Type I Cells
Death in the Taste Bud: Engulfment of Dying Taste Receptor Cells by Glial‐Like Type I Cells Open
Taste buds comprise 50–100 epithelial‐derived cells, including glial‐like cells (Type I) and two types of receptor cells (Types II and III). All of these taste cells are renewed throughout the life of an organism from a pool of uncommitted…
View article: Death in the taste bud: engulfment of dying taste receptor cells by glial-like Type I cells
Death in the taste bud: engulfment of dying taste receptor cells by glial-like Type I cells Open
Taste buds comprise 50-100 epithelial derived cells, including glial-like cells (Type I) and two types of receptor cells (Types II and III). All of these taste cells are renewed throughout the life of an organism from a pool of uncommitted…
View article: Structural comparisons of human and mouse fungiform taste buds
Structural comparisons of human and mouse fungiform taste buds Open
Taste buds are commonly studied in rodent models, but some differences exist between mice and humans in terms of gustatory mechanisms and sensitivities. Whether these functional differences are reflected in structural differences between s…
View article: Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough
Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough Open
Background Antagonists to the P2X purinergic receptors on airway sensory nerves relieve refractory or unexplained chronic cough (RCC/UCC) but can evoke unwanted dysgeusias because the gustatory nerves innervating taste buds express this sa…
View article: Taste Bud Connectome: Implications for Taste Information Processing
Taste Bud Connectome: Implications for Taste Information Processing Open
Taste buds contain multiple cell types, two of which mediate transduction of specific taste qualities: Type III cells transduce sour while Type II cells transduce either sweet, or bitter or umami. In order to discern the degree of interact…
View article: Taste Bud Connectome: Implications for Taste Information Processing
Taste Bud Connectome: Implications for Taste Information Processing Open
Taste buds contain 3 types of morphologically identifiable mature cells, 2 of which mediate transduction of specific taste qualities: Type III cells transduce sour while Type II cells transduce either sweet, bitter or umami. A long-standin…
View article: Sugar causes obesity and metabolic syndrome in mice independently of sweet taste
Sugar causes obesity and metabolic syndrome in mice independently of sweet taste Open
Intake of sugars, especially the fructose component, is strongly associated with the development of obesity and metabolic syndrome, but the relative role of taste versus metabolism in driving preference, intake, and metabolic outcome is no…
View article: Genetic Deletion of TrpV1 and TrpA1 Does Not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice
Genetic Deletion of TrpV1 and TrpA1 Does Not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice Open
Exposure of the oral cavity to acidic solutions evokes not only a sensation of sour, but also of sharp or tangy. Acidic substances potentially stimulate both taste buds and acid-sensitive mucosal free nerve endings. Mice lacking taste func…
View article: Recent advances in taste transduction and signaling
Recent advances in taste transduction and signaling Open
In the last few years, single-cell profiling of taste cells and ganglion cells has advanced our understanding of transduction, encoding, and transmission of information from taste buds as relayed to the central nervous system. This review …
View article: Genetic Deletion of TrpV1 and TrpA1 Does not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice
Genetic Deletion of TrpV1 and TrpA1 Does not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice Open
Exposure of the oral cavity to acidic solutions evokes not only a sensation of sour, but also of sharp or tangy. Acidic substances potentially stimulate both taste buds and acid-sensitive mucosal free nerve endings. Mice lacking taste func…
View article: Three‐dimensional reconstructions of mouse circumvallate taste buds using serial blockface scanning electron microscopy: I. Cell types and the apical region of the taste bud
Three‐dimensional reconstructions of mouse circumvallate taste buds using serial blockface scanning electron microscopy: I. Cell types and the apical region of the taste bud Open
Taste buds comprise four types of taste cells: three mature, elongate types, Types I–III; and basally situated, immature postmitotic type, Type IV cells. We employed serial blockface scanning electron microscopy to delineate the characteri…
View article: A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP
A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP Open
Forkhead box protein J1 (FOXJ1), a member of the forkhead family transcription factors, is a transcriptional regulator of motile ciliogenesis. The nasal respiratory epithelium, but not olfactory epithelium, is lined with FOXJ1-expressing m…
View article: Faculty Opinions recommendation of TRP channels as sensors of bacterial endotoxins.
Faculty Opinions recommendation of TRP channels as sensors of bacterial endotoxins. Open
The cellular and systemic effects induced by bacterial lipopolysaccharides (LPS) have been solely attributed to the activation of the Toll-like receptor 4 (TLR4) signalling cascade.However, recent studies have shown that LPS activates seve…
View article: A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP
A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP Open
Forkhead box protein J1 ( Foxj1 ), a member of the forkhead family transcription factors, is a transcriptional regulator of motile ciliogenesis. The nasal respiratory epithelium, but not olfactory epithelium, is lined with FOXJ1-expressing…
View article: Three-Dimensional Reconstructions of Mouse Circumvallate Taste Buds Using Serial Blockface Scanning Electron Microscopy: I. Cell Types and the Apical Region of the Taste Bud
Three-Dimensional Reconstructions of Mouse Circumvallate Taste Buds Using Serial Blockface Scanning Electron Microscopy: I. Cell Types and the Apical Region of the Taste Bud Open
Taste buds comprise four types of taste cells: 3 mature, elongate types: Type I, Type II, Type III; and basally-situated, immature post-mitotic Type IV cells. We employed serial blockface scanning electron microscopy to delineate the chara…
View article: Chemical receptors of the arytenoid: A comparison of human and mouse
Chemical receptors of the arytenoid: A comparison of human and mouse Open
Objectives/Hypothesis The larynx is a highly responsive organ exposed to mechanical, thermal, and chemical stimuli. Chemicals elicit responses both in intraepithelial nerve fibers and in specialized chemosensory cells, including scattered …
View article: Behavioral evolution drives hindbrain diversification among Lake Malawi cichlid fish
Behavioral evolution drives hindbrain diversification among Lake Malawi cichlid fish Open
The evolutionary diversification of animal behavior is often associated with changes in the structure and function of nervous systems. Such evolutionary changes arise either through alterations of individual neural components (“mosaically”…
View article: Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex
Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex Open
Atypical mitochondria generate ATP released through nearby CALHM1 channels in unconventional synapses in taste receptor cells.
View article: Type III Cells in Anterior Taste Fields Are More Immunohistochemically Diverse Than Those of Posterior Taste Fields in Mice
Type III Cells in Anterior Taste Fields Are More Immunohistochemically Diverse Than Those of Posterior Taste Fields in Mice Open
Activation of Type III cells in mammalian taste buds is implicated in the transduction of acids (sour) and salty stimuli. Several lines of evidence suggest that function of Type III cells in the anterior taste fields may differ from that o…
View article: 5‐HT<sub>3A</sub>‐driven green fluorescent protein delineates gustatory fibers innervating sour‐responsive taste cells: A labeled line for sour taste?
5‐HT<sub>3A</sub>‐driven green fluorescent protein delineates gustatory fibers innervating sour‐responsive taste cells: A labeled line for sour taste? Open
Taste buds contain multiple cell types with each type expressing receptors and transduction components for a subset of taste qualities. The sour sensing cells, Type III cells, release serotonin (5‐HT) in response to the presence of sour (a…
View article: Sonic Hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance
Sonic Hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance Open
The integrity of taste buds is intimately dependent on an intact gustatory innervation, yet the molecular nature of this dependency is unknown. Here we show differentiation of new taste bud cells, but not progenitor proliferation, is inter…
View article: Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice
Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice Open
Sensory inputs from the oropharynx terminate in both the trigeminal brainstem complex and the rostral part of the nucleus of the solitary tract (nTS). Taste information is conveyed via the facial and glossopharyngeal nerves, while general …