Thomas E. Paterson
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View article: Highly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype <i>in vitro</i>
Highly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype <i>in vitro</i> Open
Porous, biodegradable polycaprolactone microspheres support mesenchymal progenitor cell growth and differentiation. Only cells inside the microspheres differentiate into an osteocyte-like phenotype, indicating the role of physical environm…
View article: Enhanced Antibacterial Ability of Electrospun PCL Scaffolds Incorporating ZnO Nanowires
Enhanced Antibacterial Ability of Electrospun PCL Scaffolds Incorporating ZnO Nanowires Open
The infection of implanted biomaterial scaffolds presents a major challenge. Existing therapeutic solutions, such as antibiotic treatment and silver nanoparticle-containing scaffolds are becoming increasingly impractical because of the gro…
View article: Monitoring of hand function enabled by low complexity sensors printed on textile
Monitoring of hand function enabled by low complexity sensors printed on textile Open
Development of inexpensive, disposable, use-at-home, personalised health wearables can revolutionise clinical trial design and clinical care. Recent approaches have focused on electronic skins, which are complex systems of sensors and wiri…
View article: Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications
Demonstrating the Potential of Using Bio-Based Sustainable Polyester Blends for Bone Tissue Engineering Applications Open
Healthcare applications are known to have a considerable environmental impact and the use of bio-based polymers has emerged as a powerful approach to reduce the carbon footprint in the sector. This research aims to explore the suitability …
View article: Bioactive and Topographically-Modified Electrospun Membranes for the Creation of New Bone Regeneration Models
Bioactive and Topographically-Modified Electrospun Membranes for the Creation of New Bone Regeneration Models Open
Bone injuries that arise from trauma, cancer treatment, or infection are a major and growing global challenge. An increasingly ageing population plays a key role in this, since a growing number of fractures are due to diseases such as oste…
View article: Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery
Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery Open
Preventing the development of osteomyelitis while enhancing bone regeneration is challenging, with relatively little progress to date in translating promising technologies to the clinic. Nanoscale hydroxyapatite (nHA) has been employed as …
View article: Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds
Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds Open
The physiological wound healing process involves a cascade of events which could be affected by several factors resulting in chronic, non-healing wounds. The latter represent a great burden especially when bacterial biofilms are formed. Th…
View article: Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts
Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts Open
Infectious diseases (exacerbated by antimicrobial resistance) cause death, loss of quality of life and economic burden globally. Materials with inherent antimicrobial properties offer the potential to reduce the spread of infection through…
View article: Data relating to "Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts"
Data relating to "Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts" Open
This contains all of the data presented in:R. Turner et al., “Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts,” Scientific Reports, vol. 10, p. 892, 2020. [Online]. Avai…
View article: Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model
Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model Open
Bioactive glasses (BG) are versatile materials for various biomedical applications, including bone regeneration and wound healing, due to their bone bonding, antibacterial, osteogenic, and angiogenic properties. In this study, we aimed to …
View article: Porous microspheres support mesenchymal progenitor cell ingrowth and stimulate angiogenesis
Porous microspheres support mesenchymal progenitor cell ingrowth and stimulate angiogenesis Open
Porous microspheres have the potential for use as injectable bone fillers to obviate the need for open surgery. Successful bone fillers must be able to support vascularisation since tissue engineering scaffolds often cease functioning soon…
View article: Osteosarcoma growth on trabecular bone mimicking structures manufactured via laser direct write
Osteosarcoma growth on trabecular bone mimicking structures manufactured via laser direct write Open
This paper describes the direct laser write of a photocurable acrylate-based PolyHIPE (High Internal Phase Emulsion) to produce scaffolds with both macro- and microporosity, and the use of these scaffolds in osteosarcoma-based 3D cel…
View article: PolyHIPE microspheres for injectable bone tissue engineering applications
PolyHIPE microspheres for injectable bone tissue engineering applications Open
Injectable microsphere-based delivery systems have great potential in tissue engineering, since they remove the need for open surgery. Current bone filler systems for non-load bearing applications do not fully resorb and only allow regrowt…