Thomas V. Riley
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View article: Prevalence and molecular types of Clostridioides (Clostridium) difficile on Australian retail vegetables and household surfaces
Prevalence and molecular types of Clostridioides (Clostridium) difficile on Australian retail vegetables and household surfaces Open
Toxigenic strains of C. difficile were identified on retail vegetables and within households, highlighting potential for CDI to be acquired within households. Populations at high risk of CDI e.g. patients with inflammatory bowel disease or…
View article: Antimicrobial Resistance of Clostridioides (Clostridium) difficile in Cambodia
Antimicrobial Resistance of Clostridioides (Clostridium) difficile in Cambodia Open
Background/Objectives: Antimicrobial resistance (AMR) remains a major topic of interest in infectious disease management. We studied AMR in Clostridioides difficile isolated in Cambodia. Methods: Agar dilution susceptibility testing was pe…
View article: Toxigenic, atypical strains of Clostridioides difficile isolated from soils of Western Australian public parks
Toxigenic, atypical strains of Clostridioides difficile isolated from soils of Western Australian public parks Open
Public park soils in Perth, Western Australia were investigated for Clostridioides difficile. C. difficile was found at a high prevalence of 73 %. Over 19 % of the C. difficile isolates were toxigenic, including clinically relevant C. diff…
View article: Clostridioides (Clostridium) difficile in children and adolescents in the community in Cambodia
Clostridioides (Clostridium) difficile in children and adolescents in the community in Cambodia Open
The findings of only toxigenic strains in adolescents and the high prevalence of C. difficile in OPD children suggest exposure to C. difficile within the community; thus, appropriate interventions may be needed. Genotypic identification of…
View article: <i>Clostridioides difficile</i> in feral horse populations in Australia
<i>Clostridioides difficile</i> in feral horse populations in Australia Open
Clostridioides difficile is a known cause of diarrhea and colitis in human and non-human animals. While C. difficile is regularly isolated from domesticated horses, little is known about its prevalence in wild or feral populations. In Aust…
View article: <i>Clostridioides</i> ( <i>Clostridium</i> ) <i>difficile</i> infection in hospitalized adult patients in Cambodia
<i>Clostridioides</i> ( <i>Clostridium</i> ) <i>difficile</i> infection in hospitalized adult patients in Cambodia Open
Despite high levels of global concern, little is known about the epidemiology of Clostridioides ( Clostridium ) difficile infection (CDI) in Cambodia. This study aimed to identify the prevalence and risk factors for CDI, and molecular type…
View article: Complete genome sequences of toxigenic <i>Clostridioides difficile</i> isolated from Australian feral horses
Complete genome sequences of toxigenic <i>Clostridioides difficile</i> isolated from Australian feral horses Open
Recent increases in community-associated Clostridioides difficile infections have highlighted the importance of monitoring toxigenic C. difficile from animal and environmental sources. We provide the complete circularized genomes of two to…
View article: Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia Open
Clostridioides difficile infection (CDI) remains a significant public health threat globally. New interventions to treat CDI rely on an understanding of the evolution and epidemiology of circulating strains. Here we provide longitudinal ge…
View article: Biogeographic distribution and molecular epidemiology of <i>Clostridioides</i> ( <i>Clostridium</i> ) <i>difficile</i> in Western Australian soils
Biogeographic distribution and molecular epidemiology of <i>Clostridioides</i> ( <i>Clostridium</i> ) <i>difficile</i> in Western Australian soils Open
Clostridioides (Clostridium) difficile is a leading cause of infectious diarrhea in humans and production animals and can be found in a variety of environmental sources. The prevalence and diversity of multi-locus sequence type clade 5 str…
View article: A genomic survey of <i>Clostridioides difficile</i> isolates from hospitalized patients in Melbourne, Australia
A genomic survey of <i>Clostridioides difficile</i> isolates from hospitalized patients in Melbourne, Australia Open
There has been a decrease in healthcare-associated Clostridioides difficile infection (CDI) in Australia, coupled with an increase in the genetic diversity of strains isolated in these settings, and an increase in community-associated case…
View article: Genomic Analysis of Clostridioides difficile Recovered from Horses in Western Australia
Genomic Analysis of Clostridioides difficile Recovered from Horses in Western Australia Open
Clostridioides difficile poses an ongoing threat as a cause of gastrointestinal disease in humans and animals. Traditionally considered a human healthcare-related disease, increases in community-associated C. difficile infection (CDI) and …
View article: The Brief Case: a White-Colony-Producing Clostridioides difficile Ribotype 020 Strain
The Brief Case: a White-Colony-Producing Clostridioides difficile Ribotype 020 Strain Open
A bedridden elderly female patient with right hemiparesis was admitted to Siriraj Hospital, Bangkok, Thailand, with acute pyelonephritis. Considering the patient’s history of frequent hospitalization, intravenous meropenem (2 g, every 8 h)…
View article: Environmental contamination with <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i> in Vietnam
Environmental contamination with <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i> in Vietnam Open
Aims To investigate the prevalence, molecular type, and antimicrobial susceptibility of Clostridioides difficile in the environment in Vietnam, where little is known about C. difficile. Methods and results Samples of pig faeces, soils from…
View article: Complete Genome Sequences of Evolutionary Clade C-III Strains of <i>Clostridioides</i> ( <i>Clostridium</i> ) <i>difficile</i> Isolated from the Environment in Western Australia
Complete Genome Sequences of Evolutionary Clade C-III Strains of <i>Clostridioides</i> ( <i>Clostridium</i> ) <i>difficile</i> Isolated from the Environment in Western Australia Open
Clostridioides ( Clostridium ) difficile in the environment is thought to contribute to C. difficile infection in community settings. Here, we provide complete genome assemblies for two esculin hydrolysis-negative strains of C. difficile t…
View article: Genomic epidemiology and transmission dynamics of recurrent Clostridioides difficile infection in Western Australia
Genomic epidemiology and transmission dynamics of recurrent Clostridioides difficile infection in Western Australia Open
Recurrent cases of Clostridioides difficile infection (rCDI) remain one of the most common and serious challenges faced in the management of CDI. The accurate distinction between a relapse (caused by infection with the same strain) and rei…
View article: Editorial: Microbial interactions of Clostridioides difficile
Editorial: Microbial interactions of Clostridioides difficile Open
© 2023 Goh, Mullany and Riley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/
View article: Spore-Forming <i>Clostridium</i> ( <i>Clostridioides</i> ) <i>difficile</i> in Wastewater Treatment Plants in Western Australia
Spore-Forming <i>Clostridium</i> ( <i>Clostridioides</i> ) <i>difficile</i> in Wastewater Treatment Plants in Western Australia Open
Clostridium difficile infection (CDI) is a leading cause of antimicrobial-associated diarrhea in health care facilities. Extended hospital stays and recurrences increase the cost of treatment and morbidity and mortality.
View article: 221. Assessment and Proposed Revision of Clinical Trial <i>Clostridioides difficile</i> Infection Clinical Response and Outcomes Definitions
221. Assessment and Proposed Revision of Clinical Trial <i>Clostridioides difficile</i> Infection Clinical Response and Outcomes Definitions Open
Background Clostridioides difficile infection (CDI) research is limited by a lack of standardized definitions for clinical response and disease outcomes, which impacts clinical drug development and results comparison between studies. We ai…
View article: Persistence of spore-forming<i>Clostridium</i>(<i>Clostridioides</i>)<i>difficile</i>through wastewater treatment plants in Western Australia
Persistence of spore-forming<i>Clostridium</i>(<i>Clostridioides</i>)<i>difficile</i>through wastewater treatment plants in Western Australia Open
There is growing evidence that shows Clostridium ( Clostridioides ) difficile is a pathogen of One Health importance with a complex dissemination pathway involving animals, humans and the environment. Thus, environmental discharge and agri…
View article: Epidemiology of Clostridium (Clostridioides) difficile Infection in Southeast Asia
Epidemiology of Clostridium (Clostridioides) difficile Infection in Southeast Asia Open
This review describes the current understanding of Clostridium ( Clostridioides ) difficile infection (CDI) in southeast Asia regarding the prevalence of CDI, C. difficile detection methods, antimicrobial susceptibility profiles, and the p…
View article: Editorial: Clostridium difficile infection in the Asia-Pacific region
Editorial: Clostridium difficile infection in the Asia-Pacific region Open
EDITORIAL article Front. Cell. Infect. Microbiol., 26 July 2022Sec. Clinical Microbiology https://doi.org/10.3389/fcimb.2022.983563
View article: Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017
Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017 Open
Clostridioides difficile PCR ribotype (RT) 017 ranks among the most successful strains of C. difficile in the world. In the past three decades, it has caused outbreaks on four continents, more than other ‘epidemic’ strains, but our underst…
View article: Esculin hydrolysis negative and TcdA-only producing strains of <i>Clostridium (Clostridioides) difficile</i> from the environment in Western Australia
Esculin hydrolysis negative and TcdA-only producing strains of <i>Clostridium (Clostridioides) difficile</i> from the environment in Western Australia Open
Background and Aims Clostridium (Clostridiodes) difficile clade 3 ribotype (RT) 023 strains that fail to produce black colonies on bioMérieux ChromID agar have been reported, as well as variant strains of C. difficile that produce only tox…
View article: Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract
Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract Open
Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective …
View article: Ridinilazole: a novel, narrow-spectrum antimicrobial agent targeting Clostridium (Clostridioides) difficile
Ridinilazole: a novel, narrow-spectrum antimicrobial agent targeting Clostridium (Clostridioides) difficile Open
Clostridium (Clostridioides) difficile infection (CDI) remains an urgent threat to patients in health systems worldwide. Recurrent CDI occurs in up to 30% of cases due to sustained dysbiosis of the gut microbiota which normally protects ag…