Thomas E. Willnow
YOU?
Author Swipe
View article: Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes
Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes Open
INTRODUCTION Mutations in SORL1 , encoding the sorting receptor Sortilin‐related receptor with A‐type repeats (SORLA), are found in individuals with Alzheimer's disease (AD). We studied SORLA N1358S , carrying a mutation in its ligand bind…
View article: Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes
Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes Open
Sortilin-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs target proteins between endocytic and secretory compartments of cells. Mutations in SORL1 , encoding SORLA, are common in individuals s…
View article: Alzheimer's Disease Risk Gene <i>SORL1</i> Promotes Receptiveness of Human Microglia to Pro‐Inflammatory Stimuli
Alzheimer's Disease Risk Gene <i>SORL1</i> Promotes Receptiveness of Human Microglia to Pro‐Inflammatory Stimuli Open
Sorting protein‐related receptor containing class A repeats (SORLA) is an intracellular trafficking receptor encoded by the Alzheimer's disease (AD) gene SORL1 ( sortilin‐related receptor 1 ). Recent findings argue that altered expression …
View article: Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel
Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel Open
SUMMARY Sortilin ( SORT1 ) is a lipoprotein receptor that shows genome-wide association with hypercholesterolemia, explained by its ability to control hepatic output of lipoproteins. Remarkably, SORT1 also shows genome-wide association wit…
View article: Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting
Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting Open
A subset of neuroendocrine tumors (NETs) can cause an excessive secretion of hormones, neuropeptides, and biogenic amines into the bloodstream. These so-called functional NETs evoke a hormone-related disease and lead to several different s…
View article: SorLA restricts TNFα release from microglia to shape a glioma-supportive brain microenvironment
SorLA restricts TNFα release from microglia to shape a glioma-supportive brain microenvironment Open
SorLA, encoded by the gene SORL1 , is an intracellular sorting receptor of the VPS10P domain receptor gene family. Although SorLA is best recognized for its ability to shuttle target proteins between intracellular compartments in neurons, …
View article: Spatially and temporally distinct patterns of expression for VPS10P domain receptors in human cerebral organoids
Spatially and temporally distinct patterns of expression for VPS10P domain receptors in human cerebral organoids Open
Vacuolar protein sorting 10 protein (VPS10P) domain receptors are a unique class of intracellular sorting receptors that emerge as major risk factors associated with psychiatric and neurodegenerative diseases, including bipolar disorders, …
View article: Spatially and temporally distinct patterns of expression for VPS10P domain receptors in human cerebral organoids
Spatially and temporally distinct patterns of expression for VPS10P domain receptors in human cerebral organoids Open
Vacuolar protein sorting 10 protein (VPS10P) domain receptors are a unique class of intracellular sorting receptors that emerge as major risk factors associated with psychiatric and neurodegenerative diseases, including bipolar disorders, …
View article: Sorting receptor SORCS2 facilitates a protective stress response in pancreatic islets
Sorting receptor SORCS2 facilitates a protective stress response in pancreatic islets Open
Objective SORCS2 is an intracellular sorting receptor genetically associated with body mass index (BMI) in humans, yet its mode of action remains unknown. Elucidating the receptor function that defines its role in metabolic health is the o…
View article: SorLA restricts TNFα release from microglia to shape glioma-supportive brain microenvironment
SorLA restricts TNFα release from microglia to shape glioma-supportive brain microenvironment Open
SorLA, encoded by the gene SORL1 , is an intracellular sorting receptor of the VPS10P domain receptor gene family. Although SorLA is best recognized for its ability to shuttle target proteins between intracellular compartments in neurons, …
View article: Supplementary Figures S1-S6 and Tables from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men
Supplementary Figures S1-S6 and Tables from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men Open
S1. Accompanies Figure 1 and 2.S2. Accompanies Figure 2. No differences in bitransgenic mouse prostate histology, weights and fertility.S3. Relates to Figure 3. Vitamin D receptor and androgen receptor response elements in LRP2 promoter.S4…
View article: Data from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men
Data from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men Open
Vitamin D deficiency is associated with an increased risk of prostate cancer mortality and is hypothesized to contribute to prostate cancer aggressiveness and disparities in African American populations. The prostate epithelium was recentl…
View article: Supplementary Figures S1-S6 and Tables from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men
Supplementary Figures S1-S6 and Tables from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men Open
S1. Accompanies Figure 1 and 2.S2. Accompanies Figure 2. No differences in bitransgenic mouse prostate histology, weights and fertility.S3. Relates to Figure 3. Vitamin D receptor and androgen receptor response elements in LRP2 promoter.S4…
View article: Data from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men
Data from Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men Open
Vitamin D deficiency is associated with an increased risk of prostate cancer mortality and is hypothesized to contribute to prostate cancer aggressiveness and disparities in African American populations. The prostate epithelium was recentl…
View article: LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function
LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function Open
Motile cilia are protruding organelles on specialized epithelia that beat in a synchronous fashion to propel extracellular fluids. Coordination and orientation of cilia beating on individual cells and across tissues is a complex process de…
View article: Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men
Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men Open
Vitamin D deficiency is associated with an increased risk of prostate cancer mortality and is hypothesized to contribute to prostate cancer aggressiveness and disparities in African American populations. The prostate epithelium was recentl…
View article: LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function
LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function Open
Motile cilia are protruding organelles on specialized epithelia that beat in a synchronous fashion to propel extracellular fluids. Coordination and orientation of cilia beating on individual cells and across tissues is a complex process de…
View article: SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition Open
Aims/ hypothesis Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic st…
View article: SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat
SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat Open
Visceral adipose tissue shows remarkable plasticity, constantly replacing mature adipocytes from an inherent pool of adipocyte precursors. The number of precursors is set in the juvenile organism and remains constant in adult life. Which s…
View article: Regulation of prostate androgens by megalin and 25-hydroxyvitamin D status: Mechanism for high prostate androgen in African American men
Regulation of prostate androgens by megalin and 25-hydroxyvitamin D status: Mechanism for high prostate androgen in African American men Open
Vitamin D deficiency is associated with an increased risk of prostate cancer (PCa) mortality and is hypothesized to contribute to PCa aggressiveness and disparities in African American populations. The prostate epithelium was recently show…
View article: GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium
GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium Open
Growth arrest-specific 1 (GAS1) acts as a co-receptor to patched 1, promoting sonic hedgehog (SHH) signaling in the developing nervous system. GAS1 mutations in humans and animal models result in forebrain and craniofacial malformations, d…
View article: ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling
ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling Open
Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the br…
View article: Corrigendum to Flemming J, Marczenke M, Rudolph I-M, et al. Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome. Kidney Int. 2020;98:159–167
Corrigendum to Flemming J, Marczenke M, Rudolph I-M, et al. Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome. Kidney Int. 2020;98:159–167 Open
In the above-stated article, the given name and surname one of the authors, Erik Ilsoe Christensen, was presented inaccurately. The given name is Erik and the surname is Ilsoe Christensen. In addition, an additional affiliation of Maike Ma…
View article: ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling
ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling Open
Sortilin is a receptor for neuronal uptake of apolipoprotein E. Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the…