Thomas Ebenhan
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View article: Mini-review and situation report on the role and usefulness of nuclear medicine imaging for malaria
Mini-review and situation report on the role and usefulness of nuclear medicine imaging for malaria Open
Malaria remains one of the deadliest parasitic diseases globally. Delay or failure in treatment can lead to the development of severe malaria. Severe malaria, an understudied multisystem disease, affects the host’s organs and can lead to s…
View article: PET imaging of mycobacterial infection: transforming the pipeline for tuberculosis drug development
PET imaging of mycobacterial infection: transforming the pipeline for tuberculosis drug development Open
View article: Synthesis and characterisation of <scp>DOTA</scp> ‐kisspeptin‐10 as a potential gallium‐68/lutetium‐177 pan‐tumour radiopharmaceutical
Synthesis and characterisation of <span>DOTA</span> ‐kisspeptin‐10 as a potential gallium‐68/lutetium‐177 pan‐tumour radiopharmaceutical Open
Kisspeptin (KISS1) and its cognate receptor (KISS1R) are implicated in the progression of various cancers. A gallium‐68 labelled kisspeptin‐10 (KP10), the minimal biologically active structure, has potential as a pan‐tumour radiopharmaceut…
View article: Gallium-68-NODASA-Functionalized D-Lysine Radiosynthesis and first-line in vitro characterization - a potential PET imaging agent for infection
Gallium-68-NODASA-Functionalized D-Lysine Radiosynthesis and first-line in vitro characterization - a potential PET imaging agent for infection Open
The advancement of new Positron Emission Tomography (PET) radiotracers for differentiating bacterial infections from sterile inflammation is essential for accurate diagnosis and treatment monitoring. D-amino acid-based probes have shown pr…
View article: A proof-of-concept study to investigate the radiolabelling of human mesenchymal and hematopoietic stem cells with [89Zr]Zr-Df-Bz-NCS
A proof-of-concept study to investigate the radiolabelling of human mesenchymal and hematopoietic stem cells with [89Zr]Zr-Df-Bz-NCS Open
Successful 89Zr-MSC and 89Zr-HSPC labelling was achieved, which underlines the prospects for in vivo cell tracking studies with positron emission tomography. In vitro investigations with larger sample sizes and precli…
View article: Evaluation of [68Ga]Ga-DOTA-AeK as a Potential Imaging Tool for PET Imaging of Cell Wall Synthesis in Bacterial Infections
Evaluation of [68Ga]Ga-DOTA-AeK as a Potential Imaging Tool for PET Imaging of Cell Wall Synthesis in Bacterial Infections Open
The ability of bacteria to recycle exogenous amino acid-based peptides and amino sugars for peptidoglycan biosynthesis was extensively investigated using optical imaging. In particular, fluorescent AeK–NBD was effectively utilized to study…
View article: Visualisation of in vivo protein synthesis during mycobacterial infection through [68Ga]Ga-DOTA-puromycin µPET/MRI
Visualisation of in vivo protein synthesis during mycobacterial infection through [68Ga]Ga-DOTA-puromycin µPET/MRI Open
Radiolabelled puromycin analogues will allow the quantification of protein synthesis through nuclear medicine-based imaging. A particularly useful application could be the non-invasive longitudinal visualisation of mycobacterial activity t…
View article: <sup>68</sup>Ga Radiolabeling of NODASA‐Functionalized Phage Display–Derived Peptides for Prospective Assessment as Tuberculosis‐Specific PET Radiotracers
<sup>68</sup>Ga Radiolabeling of NODASA‐Functionalized Phage Display–Derived Peptides for Prospective Assessment as Tuberculosis‐Specific PET Radiotracers Open
This research presents the development of positron emission tomography (PET) radiotracers for detecting Mycobacterium tuberculosis (MTB) for the diagnosis and monitoring of tuberculosis. Two phage display–derived peptides with proven selec…
View article: First-in-human infection imaging with 89Zr-labelled leukocytes and comparison of scan quality with [99mTc]Tc-HMPAO-labelled leukocytes
First-in-human infection imaging with 89Zr-labelled leukocytes and comparison of scan quality with [99mTc]Tc-HMPAO-labelled leukocytes Open
Introduction Nuclear medicine infection imaging is routinely performed with the use of leukocytes radiolabelled with technetium-99m hexamethylpropyleneamine oxime ([ 99m Tc]Tc-HMPAO) and single-photon emission computed tomography (SPECT). …
View article: Recently developed radiopharmaceuticals for bacterial infection imaging
Recently developed radiopharmaceuticals for bacterial infection imaging Open
View article: The Clinical Utility of Molecular Imaging Using Nuclear Medicine Tools in the Management of All Stages of Adult Gliomas
The Clinical Utility of Molecular Imaging Using Nuclear Medicine Tools in the Management of All Stages of Adult Gliomas Open
Gliomas are common primary central nervous system (CNS) tumours which are often very difficult to diagnose, stage and manage because of their heterogeneity and molecular aberrations. The notable hallmark of gliomas is integrated genome mut…
View article: Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy?
Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy? Open
View article: Insights into Peptidoglycan-Targeting Radiotracers for Imaging Bacterial Infections: Updates, Challenges, and Future Perspectives
Insights into Peptidoglycan-Targeting Radiotracers for Imaging Bacterial Infections: Updates, Challenges, and Future Perspectives Open
The unique structural architecture of the peptidoglycan allows for the stratification of bacteria as either Gram-negative or Gram-positive, which makes bacterial cells distinguishable from mammalian cells. This classification has received …
View article: The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection
The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection Open
The International Atomic Energy Agency organized a technical meeting at its headquarters in Vienna, Austria, in 2022 that included 17 experts representing 12 countries, whose research spanned the development and use of radiolabeled agents …
View article: Preclinical Research Highlighting Contemporary Targeting Mechanisms of Radiolabelled Compounds for PET Based Infection Imaging
Preclinical Research Highlighting Contemporary Targeting Mechanisms of Radiolabelled Compounds for PET Based Infection Imaging Open
It is important to constantly monitor developments in the preclinical imaging arena of infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be identified to funnel into the clinic. Secondly, it must be evalu…
View article: Introducing HDAC-Targeting Radiopharmaceuticals for Glioblastoma Imaging and Therapy
Introducing HDAC-Targeting Radiopharmaceuticals for Glioblastoma Imaging and Therapy Open
Despite recent advances in multimodality therapy for glioblastoma (GB) incorporating surgery, radiotherapy, chemotherapy and targeted therapy, the overall prognosis remains poor. One of the interesting targets for GB therapy is the histone…
View article: Tachykinin Receptor-Selectivity of the Potential Glioblastoma-Targeted Therapy, DOTA-[Thi8,Met(O2)11]-Substance P
Tachykinin Receptor-Selectivity of the Potential Glioblastoma-Targeted Therapy, DOTA-[Thi8,Met(O2)11]-Substance P Open
Radiopharmaceutical development hinges on the affinity and selectivity of the biological component for the intended target. An analogue of the neuropeptide Substance P (SP), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-[Thi8,Me…
View article: The SARS-COV-2 Seroprevalence among Oncology Patients
The SARS-COV-2 Seroprevalence among Oncology Patients Open
Patients with cancer are presumed to be vulnerable to an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe clinical outcomes due to the immunocompromised state mediated by their underlying …
View article: Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging?
Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging? Open
The excellent features of non‐invasive molecular imaging, its progressive technology (real‐time, whole‐body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are enco…
View article: Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging?
Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging? Open
The excellent features of non‐invasive molecular imaging, its progressive technology (real‐time, whole‐body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are enco…
View article: Using Antibiotics Scaffolds Will Warrant Novel Radiotracers for Effective Positron Emission Tomography Imaging of Infections: Triumph or Pitfall?
Using Antibiotics Scaffolds Will Warrant Novel Radiotracers for Effective Positron Emission Tomography Imaging of Infections: Triumph or Pitfall? Open
The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are enco…
View article: Perspective on the Use of DNA Repair Inhibitors as a Tool for Imaging and Radionuclide Therapy of Glioblastoma
Perspective on the Use of DNA Repair Inhibitors as a Tool for Imaging and Radionuclide Therapy of Glioblastoma Open
Despite numerous innovative treatment strategies, the treatment of glioblastoma (GB) remains challenging. With the current state-of-the-art therapy, most GB patients succumb after about a year. In the evolution of personalized medicine, ta…
View article: Towards Facile Radiolabeling and Preparation of Gallium-68-/Bismuth-213-DOTA-[Thi8, Met(O2)11]-Substance P for Future Clinical Application: First Experiences
Towards Facile Radiolabeling and Preparation of Gallium-68-/Bismuth-213-DOTA-[Thi8, Met(O2)11]-Substance P for Future Clinical Application: First Experiences Open
Substance P (SP) is a small peptide commonly known as a preferential endogenous ligand for the transmembrane neurokinin-1 receptor. Nuclear Medicine procedures currently involve radiolabeled SP derivatives in peptide radioligand endotherap…
View article: Obstacles and Recommendations for Clinical Translation of Nanoparticle System-Based Targeted Alpha-Particle Therapy
Obstacles and Recommendations for Clinical Translation of Nanoparticle System-Based Targeted Alpha-Particle Therapy Open
The rationale for application of nanotechnology in targeted alpha therapy (TAT) is sound. However, the translational strategy requires attention. Formulation of TAT in nanoparticulate drug delivery systems has the potential to resolve many…
View article: Novel Receptor Tyrosine Kinase Pathway Inhibitors for Targeted Radionuclide Therapy of Glioblastoma
Novel Receptor Tyrosine Kinase Pathway Inhibitors for Targeted Radionuclide Therapy of Glioblastoma Open
Glioblastoma (GB) remains the most fatal brain tumor characterized by a high infiltration rate and treatment resistance. Overexpression and/or mutation of receptor tyrosine kinases is common in GB, which subsequently leads to the activatio…
View article: Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution Open
It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicit…
View article: Correction to: Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents
Correction to: Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents Open
View article: A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma
A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma Open
Despite numerous clinical trials and pre-clinical developments, the treatment of glioblastoma (GB) remains a challenge. The current survival rate of GB averages one year, even with an optimal standard of care. However, the future promises …
View article: <i>In Vivo</i> Albumin‐Binding of a <i>C</i> ‐Functionalized Cyclam Platform for <sup>64</sup> Cu‐PET/CT Imaging in Breast Cancer Model
<i>In Vivo</i> Albumin‐Binding of a <i>C</i> ‐Functionalized Cyclam Platform for <sup>64</sup> Cu‐PET/CT Imaging in Breast Cancer Model Open
An improved glucose‐chelator‐albumin bioconjugate (GluCAB) derivative, GluCAB‐2 Mal , has been synthesized and studied for in vivo 64 Cu‐PET/CT imaging in breast cancer mice models together with its first‐generation analogue GluCAB‐1 Mal .…
View article: In vivo evaluation of acute intravenous toxicity of a [68Ga]Ga-PSMA-11- microemulsion
In vivo evaluation of acute intravenous toxicity of a [68Ga]Ga-PSMA-11- microemulsion Open
Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated within the M…