Thomas Eickner
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View article: Degradation Behavior of an Amino Acid- Substituted Polyphosphazene with Triethyl Citrate as Plasticizer
Degradation Behavior of an Amino Acid- Substituted Polyphosphazene with Triethyl Citrate as Plasticizer Open
A novel phenylalanine/ valine ethyl ester cosubstituted polyorganophosphazene, incorporating triethyl citrate as plasticizer, is being investigated for its degradability. Films were solvent casted, and allowed to degrade for 4 weeks at an …
View article: Two-component periodontal depot for sustained release of Chlorhexidine
Two-component periodontal depot for sustained release of Chlorhexidine Open
Periodontitis is a prevalent chronic inflammatory disease that requires effective long-term treatment strategies. Current antimicrobial formulations, such as Chlorhexidine (CHX) gels and antibiotic-based inserts, often suffer from short re…
View article: Enzymatic Degradation of a g-Cyclodextrin- Hyaluronic Acid Copolymer
Enzymatic Degradation of a g-Cyclodextrin- Hyaluronic Acid Copolymer Open
Postoperative scarring following trabeculectomy, a glaucoma surgery, often leads to failure, necessitating biodegradable drug delivery systems for sustained antifibrotic release. This study explores γ-cyclodextrin/hyaluronic acid (γ- CD/HA…
View article: Manufacture and characterisation of PLLA films with incorporated cobalt metalparticles
Manufacture and characterisation of PLLA films with incorporated cobalt metalparticles Open
To study the effects of metal ions on cells and tissues caused by wear and corrosion of implants in vitro, a system is required that releases metal ions in a controlled and sustained manner. As small concentrations can have an impact on bi…
View article: Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival
Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival Open
Cochlear implants are well established devices for treating severe hearing loss. However, due to the trauma caused by the insertion of the electrode and the subsequent formation of connective tissue, their clinical effectiveness varies. Th…
View article: Precise processing of pure undiluted PEGDA via inkjet printing for drug release systems
Precise processing of pure undiluted PEGDA via inkjet printing for drug release systems Open
Poly(ethylene glycol) diacrylate (PEGDA) is a common polymer in the field of biomedical engineering and can be used for the production of drug delivery systems (DDS). The main advantages of PEGDA are biocompatibility and the ability to alt…
View article: Antifibrotic Drug Delivery for Glaucoma Treatment – Determination of Josamycin in vivo
Antifibrotic Drug Delivery for Glaucoma Treatment – Determination of Josamycin in vivo Open
Antifibrotic treatment during glaucoma surgery leads to an improved outcome for patients. Drug delivery systems for placement under the subconjuctiva after surgery made of cyclodextrins and crosslinked with Epichlorohydin were loaded with …
View article: Degradation und mechanical behavior of nanofiber membranes for timed release of antibacterial additives
Degradation und mechanical behavior of nanofiber membranes for timed release of antibacterial additives Open
Ultrafine membranes produced via electrospinning exhibit multidirectional strength and elasticity. In contrast to compact polymer films or coatings, they also have an exceptional surface-to-volume ratio, which makes them attractive carrier…
View article: Molded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model
Molded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model Open
Background: Preserving residual hearing after cochlear implant (CI) surgery remains a crucial challenge. The application of dexamethasone (DEX) has been proven to positively affect residual hearing. To deliver DEX in a localized and contro…
View article: Development of a drug delivering round window niche implant for cochlear pharmacotherapy
Development of a drug delivering round window niche implant for cochlear pharmacotherapy Open
We developed a GP-RNI that can be used for precise inner ear drug delivery in guinea pigs, providing a reliable platform for testing the RNI's safety and efficacy, with potential implications for future clinical translation.
View article: γ-Cyclodextrin hydrogel for the sustained release of josamycin for potential ocular application
γ-Cyclodextrin hydrogel for the sustained release of josamycin for potential ocular application Open
Glaucoma is the leading cause of blindness worldwide. However, its surgical treatment, in particular via trabeculectomy, can be complicated by fibrosis. In current clinical practice, application of the drug, Mitomycin C, prevents or delays…
View article: 3-Sulfopropyl acrylate potassium-based polyelectrolyte hydrogels: sterilizable synthetic material for biomedical application
3-Sulfopropyl acrylate potassium-based polyelectrolyte hydrogels: sterilizable synthetic material for biomedical application Open
AESO 3 -PEGDA hydrogels are well suited for sterilization by common sterilization methods, enabling their use in biomedicine.
View article: Inkjet printability of Celecoxib drug solutions
Inkjet printability of Celecoxib drug solutions Open
Inkjet printing is a versatile tool for the precise positioning of droplets that is used in many application areas such as 3D printing, biotechnology or pharmacy. This work focused on comparing the inkjet printability of different drug sol…
View article: Manufacture and extraction of PLLA films with incorporated metal ions
Manufacture and extraction of PLLA films with incorporated metal ions Open
For the in vitro examination of the effects on cells and tissues of metal ions derived from implants by wear and corrosion, a system is needed to release metal ions in a controlled and sustained manner. As small concentrations may have an …
View article: Optimized Gingiva Cell Behavior on Dental Zirconia as a Result of Atmospheric Argon Plasma Activation
Optimized Gingiva Cell Behavior on Dental Zirconia as a Result of Atmospheric Argon Plasma Activation Open
Several physico-chemical modifications have been developed to improve cell contact with prosthetic oral implant surfaces. The activation with non-thermal plasmas was one option. Previous studies found that gingiva fibroblasts on laser-micr…
View article: Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds
Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds Open
A novel approach for the long-term medical treatment of the inner ear is the diffusion of drugs through the round window membrane from a patient-individualized, drug-eluting implant, which is inserted in the middle ear. In this study, drug…
View article: Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model using 3D Printed Molds
Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model using 3D Printed Molds Open
A novel approach for the long-term medical treatment of the inner ear is the diffusion of drugs through the round window membrane from a patient-individualized, drug-eluting implant, which is inserted in the middle ear. In this study, drug…
View article: Dual Drug Delivery in Cochlear Implants: In Vivo Study of Dexamethasone Combined with Diclofenac or Immunophilin Inhibitor MM284 in Guinea Pigs
Dual Drug Delivery in Cochlear Implants: In Vivo Study of Dexamethasone Combined with Diclofenac or Immunophilin Inhibitor MM284 in Guinea Pigs Open
Cochlear implants are well established to treat severe hearing impairments. Despite many different approaches to reduce the formation of connective tissue after electrode insertion and to keep electrical impedances low, results are not yet…
View article: XPS-Analysis of solvent residues in different polymeric biomaterials
XPS-Analysis of solvent residues in different polymeric biomaterials Open
For the use of polymers as biomaterials in the production of implants, several processing methods are needed. Besides injection molding or Fused Deposition Modeling as temperature based processes, also solvent based processes were performe…
View article: Chemical characterization of plasma polymerized allylamine coatings with addition of ammonia and oxygen by XPS
Chemical characterization of plasma polymerized allylamine coatings with addition of ammonia and oxygen by XPS Open
In addition to wet-and plasma chemical surface activation, the deposition of stable organic coatings by plasma enhanced chemical vapor deposition (PECVD) using reactive monomers, such as aminosilanes and allylamine, is often described to g…
View article: Determination of Infusion Filter Efficiency applying Dynamic Light Scattering
Determination of Infusion Filter Efficiency applying Dynamic Light Scattering Open
Filter membranes (pore size 0.2 μm) are frequently used to perform a sterile filtration. To characterize the pore size of filter membranes, a method to determine the particle retention of nanoparticles was defined. The Dynamic Light Scatte…
View article: The influence of PEGDA’s molecular weight on its mechanical properties in the context of biomedical applications
The influence of PEGDA’s molecular weight on its mechanical properties in the context of biomedical applications Open
Hydrogels are 3D polymeric networks, which exhibit properties such as softness, viscoelasticity and their ability to absorb large amounts of water. These characteristics make them exceptionally suitable in biomedicine as e.g. tissue scaffo…
View article: Surface analysis of different O<sub>2</sub>-activated polyurethane-co-silicones using XPS
Surface analysis of different O<sub>2</sub>-activated polyurethane-co-silicones using XPS Open
Polycarbonate-urethane-co-silicone (PCU-Sil) are gaining increasing interest in biomedical application, such as drug delivery systems, coatings and combination products, due to their adjustable mechanical properties. They can be easily pro…
View article: Thermal, Mechanical and Biocompatibility Analyses of Photochemically Polymerized PEGDA250 for Photopolymerization-Based Manufacturing Processes
Thermal, Mechanical and Biocompatibility Analyses of Photochemically Polymerized PEGDA250 for Photopolymerization-Based Manufacturing Processes Open
Novel fabrication techniques based on photopolymerization enable the preparation of complex multi-material constructs for biomedical applications. This requires an understanding of the influence of the used reaction components on the prope…
View article: PLLA Coating of Active Implants for Dual Drug Release
PLLA Coating of Active Implants for Dual Drug Release Open
Cochlear implants, like other active implants, rely on precise and effective electrical stimulation of the target tissue but become encapsulated by different amounts of fibrous tissue. The current study aimed at the development of a dual d…
View article: Comparison of accelerated and enzyme-associated real-time degradation of HMW PLLA and HMW P3HB films
Comparison of accelerated and enzyme-associated real-time degradation of HMW PLLA and HMW P3HB films Open
Designing laboratory-scale degradation experiments for polymer-based biomaterials is crucial for the development of safe and functional implants, in particular regarding high molecular weight polyesters. Within this work, we compared accel…
View article: Influence of sterilization on the drug release behaviour of drug coated silicone
Influence of sterilization on the drug release behaviour of drug coated silicone Open
Sterilization processes ensure sterility of drug delivery systems, but may negatively affect the properties of biomaterials and incorporated drugs by changing their physical, chemical, mechanical properties and drug release behaviour. Ther…
View article: A hydrogel based quasi-stationary test system for in vitro dexamethasone release studies for middle ear drug delivery systems
A hydrogel based quasi-stationary test system for in vitro dexamethasone release studies for middle ear drug delivery systems Open
For the investigation of in vitro drug release, methods have been used in which samples of drug delivery systems are immersed in release medium. The medium is used to measure drug concentration via chromatography or photometry. These syste…
View article: Investigations of Surface Interactions between PEGDA-Polymer and Drug using Surface Plasmon Resonance
Investigations of Surface Interactions between PEGDA-Polymer and Drug using Surface Plasmon Resonance Open
For the development of combination products, the determination of the release kinetics of polymer-based drug delivery systems (DDS) is a central and often timeconsuming investigation. Classical methods are often unsuitable for large-scale …