Thomas Eisler
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View article: Asymptomatic osteolysis as a risk factor for cardiovascular disease after total hip arthroplasty: A retrospective cohort study
Asymptomatic osteolysis as a risk factor for cardiovascular disease after total hip arthroplasty: A retrospective cohort study Open
Background and purpose A clinical problem in total hip arthroplasty (THA) is periprosthetic osteolysis/aseptic loosening. There is a possible association between periprosthetic osteolysis and higher risk of cardiovascular disease (CVD). Th…
View article: A Novel Fluorescent Immuno-Lectin Assay to Identify Osteoarthritis Associated Glycoforms of Lubricin
A Novel Fluorescent Immuno-Lectin Assay to Identify Osteoarthritis Associated Glycoforms of Lubricin Open
Lubricin or proteoglycan-4 (PRG-4) is a mucinous glycoprotein lubricating the cartilage and maintaining normal tissue function and cell-homeostasis. Altered O -glycoforms of lubricin has been found in osteoarthritis (OA) synovial fluid (SF…
View article: Increased mortality after total hip prosthetic joint infection is mainly caused by the comorbidities rather than the infection itself
Increased mortality after total hip prosthetic joint infection is mainly caused by the comorbidities rather than the infection itself Open
Background and purpose: Periprosthetic joint infection (PJI) is a feared complication of arthroplasty surgery. There is controversy as to whether PJI also correlates with increased mortality. Our aim was to investigate in a nationwide coho…
View article: Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines
Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines Open
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the…
View article: EPOS trial: the effect of air filtration through a plasma chamber on the incidence of surgical site infection in orthopaedic surgery: a study protocol of a randomised, double-blind, placebo-controlled trial
EPOS trial: the effect of air filtration through a plasma chamber on the incidence of surgical site infection in orthopaedic surgery: a study protocol of a randomised, double-blind, placebo-controlled trial Open
Introduction There is controversy regarding the importance of air-transmitted infections for surgical site infections (SSIs) after orthopaedic surgery. Research has been hindered by both the inability in blinding the exposure, and by the n…
View article: The level of synovial human VEGFA, IL-8 and MIP-1α correlate with truncation of lubricin glycans in osteoarthritis
The level of synovial human VEGFA, IL-8 and MIP-1α correlate with truncation of lubricin glycans in osteoarthritis Open
Osteoarthrithis (OA) is an endemic disease due to the increase of the world’s elderly population. Previously thought to be a consequence of an imbalance between cartilage degradation and biosynthesis, it is now recognized as a disease also…
View article: Author Correction: Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin
Author Correction: Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking
Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking Open
The synovial fluid glycoprotein lubricin (also known as proteoglycan 4) is a mucin-type O-linked glycosylated biological lubricant implicated to be involved in osteoarthritis (OA) development. Lubricin's ability to reduce friction is relat…
View article: The Sernbo score as a predictor of 1-year mortality after hip fracture: a registry study on 55,716 patients
The Sernbo score as a predictor of 1-year mortality after hip fracture: a registry study on 55,716 patients Open
Purpose Patients sustaining a hip fracture have a high mortality rate during the first postoperative year and the Sernbo score may stratify patients into a high, intermediate and low risk of death during this period. We assessed its predic…
View article: Cathepsin g degrades synovial fluid lubricin: relevance for osteoarthritis pathogenesis
Cathepsin g degrades synovial fluid lubricin: relevance for osteoarthritis pathogenesis Open
Lubricin (PRG4) is a mucin type protein that plays an important role in maintaining normal joint function by providing lubrication and chondroprotection. Improper lubricin modification and degradation has been observed in idiopathic osteoa…
View article: Aseptic loosening after total hip arthroplasty and the risk of cardiovascular disease: A nested case-control study
Aseptic loosening after total hip arthroplasty and the risk of cardiovascular disease: A nested case-control study Open
Patients with osteoarthritis who received THA and subsequently underwent a revision operation due to loosening had a higher relative risk of developing cardiovascular events than controls. Thus there is an association which could be explai…
View article: The Sernbo score predicts 1-year mortality after displaced femoral neck fractures treated with a hip arthroplasty
The Sernbo score predicts 1-year mortality after displaced femoral neck fractures treated with a hip arthroplasty Open
Background and purpose — Displaced femoral neck fractures (FNFs) are associated with high rates of mortality during the first postoperative year. The Sernbo score (based on age, habitat, mobility, and mental state) can be used to stratify …
View article: Migration and head penetration of Vitamin-E diffused cemented polyethylene cup compared to standard cemented cup in total hip arthroplasty: study protocol for a randomised, double-blind, controlled trial (E1 HIP)
Migration and head penetration of Vitamin-E diffused cemented polyethylene cup compared to standard cemented cup in total hip arthroplasty: study protocol for a randomised, double-blind, controlled trial (E1 HIP) Open
Introduction In vitro, Vitamin-E-diffused, highly cross-linked polyethylene (PE) has been shown to have superior wear resistance and improved mechanical properties when compared to those of standard highly cross-linked PE liners used in to…
View article: Denosumab for treating periprosthetic osteolysis; study protocol for a randomized, double-blind, placebo-controlled trial
Denosumab for treating periprosthetic osteolysis; study protocol for a randomized, double-blind, placebo-controlled trial Open
ClinicalTrials.gov (NCT02299817) 2014-11-20.
View article: Increased Long-Term Cardiovascular Risk After Total Hip Arthroplasty
Increased Long-Term Cardiovascular Risk After Total Hip Arthroplasty Open
Total hip arthroplasty is a common and important treatment for osteoarthritis patients. Long-term cardiovascular effects elicited by osteoarthritis or the implant itself remain unknown. The purpose of the present study was to determine if …