Thomas Enkel
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View article: Comment on Flagel et al.: Sign-tracking as a predictor of addiction vulnerability
Comment on Flagel et al.: Sign-tracking as a predictor of addiction vulnerability Open
Computed tomography (CT) imaging in acute stroke is an established and fairly widespread approach, but there is no data on applicability of intraosseous (IO) contrast administration in the case of failed intravenous (IV) cannula placement.…
View article: Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration
Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration Open
Rationale In classical conditioning, sign-tracking reflects behavior directed toward a conditioned stimulus (CS) in expectation of a reward (unconditioned stimulus, US); in contrast, goal-tracking describes behavior directed toward the loc…
View article: Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats
Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats Open
Pavlovian learning plays a prominent role in the etiology of addiction. The influence of Pavlovian conditioning on the expression of an instrumental response can be studied using the Pavlovian-to-instrumental transfer (PIT) paradigm. This …
View article: Behavioral Effects of Acute Systemic Low-Dose Clozapine in Wild-Type Rats: Implications for the Use of DREADDs in Behavioral Neuroscience
Behavioral Effects of Acute Systemic Low-Dose Clozapine in Wild-Type Rats: Implications for the Use of DREADDs in Behavioral Neuroscience Open
Designer receptors exclusively activated by designer drugs (DREADDs) are popular tools used to manipulate the activity of defined groups of neurons. Recent work has shown that DREADD effects in the brain are most likely not mediated by the…
View article: Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene
Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene Open
The Research Domain Criteria (RDoC) matrix has been developed to reorient psychiatric research towards measurable behavioral dimensions and underlying mechanisms. Here we used a new genetic rat model with a loss of function point mutation …