Explanipedia

Phenogrouping HFpEF trajectories identifies early and end-stage subtypes: a multicentre study using natural language processing Open

Samuel Brown, F Soltani, JIAWEI WU, Bruce Bernstein, Mahrukh Rizvi , et al. · 2025

Background Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous and frequently underdiagnosed syndrome, complicating timely intervention. Previous clustering studies were predominantly trial-based, limiting real-world …

Transcatheter Valve Implantation for Aortic Stenosis: Acronym Matters Open

Ciro Indolfi, Giovanni Esposito, Carmen Spaccarotella, Thomas F. Lüscher · 2025

In 2002, Alain Cribier performed the first transcatheter aortic valve implantation (TAVI). Since then, TAVI has evolved from an experimental procedure into a consolidated and globally widespread therapeutic strategy. To date, nearly 3 mill…

Age- and sex-specific transcriptomic changes drive the prothrombotic potential of megakaryocytes Open

Pratintip Lee, Carolina Balbi, Meret Allemann, Adhideb Ghosh, Tongtong Wang , et al. · 2025

Aging is associated with enhanced platelet activation and inflammatory responses, contributing to an increased risk of thrombotic and cardiovascular events. However, how megakaryocytes (Mk) change with age or between sexes is still unclear…

Left Atrial Appendage Occlusion Using the Amplatzer Amulet Device in High-Risk Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Intervention: A Randomized Pilot Study Open

Philipp Jakob, Priska Heinz, Yiqi Gong, Chen Mi, Ronald K. Binder , et al. · 2025

Background: Patients with severe aortic stenosis and atrial fibrillation (AF) undergoing transcatheter aortic valve intervention (TAVI) are at increased risk of bleeding and cerebrovascular events. This investigator-initiated, randomized, …

Artificial Intelligence Methods to Detect Heart Failure with Preserved Ejection Fraction (AIM-HFpEF) within Electronic Health Records: An equitable disease detection model Open

Jack Wu, Dhruva Biswas, Sam P. Brown, M. J. Ryan, Brett Bernstein , et al. · 2025

Background and aims Heart Failure with Preserved Ejection Fraction (HFpEF) accounts for approximately half of all heart failure cases, with high levels of morbidity and mortality. However, many patients who meet diagnostic criteria for HFp…

Impact of diabetes on outcomes of patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease undergoing percutaneous coronary intervention Open

Philipp Jakob, Ferdinando Varbella, Axel Linke, Bettina Schwarz, Stephan B. Felix , et al. · 2025

Background Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presentin…

Performance of artificial intelligence-generated vs human-authored abstracts in a real-world setting Open

Karl‐Patrik Kresoja, Anne Rebecca Schöber, Thomas F. Lüscher, Tharusan Thevathasan, Philipp Lurz , et al. · 2025

Respiratory viruses, vaccines, and the heart: lessons from DANFLU-2, DAN-RSV, and beyond Open

Bettina Heidecker, Thomas F. Lüscher · 2025

5-007 Unsupervised clustering reveals early and late heart failure with preserved ejection fraction phenogroups with distinct clinical trajectories Open

Sam P. Brown, Fardad Soltani, Jack Wu, Brett Sydney Bernstein, Maleeha Rizvi , et al. · 2025

Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes Open

Maëlle Achard, Cédric Follonier, Évelyne Fournier, David Carballo, Mattia Branca , et al. · 2025

Background Despite universal coverage, inequities persist in acute coronary syndrome (ACS) care. This study examines how educational levels impact the quality and outcomes of health care. Methods A cohort of ACS patients hospitalized in fi…

Artificial intelligence in cardiovascular pharmacotherapy: applications and perspectives Open

Francesco Costa, Juan José Gómez‐Doblas, Arancha Díaz Expósito, Marianna Adamo, Fabrizio D’Ascenzo , et al. · 2025

Recent advances in artificial intelligence (AI) have shown great potential in improving cardiovascular pharmacotherapy by optimizing drug selection, predicting therapeutic efficacy and adverse effects, ultimately improving patient outcomes…

Vaccination as a new form of cardiovascular prevention: a European Society of Cardiology clinical consensus statement Open

Bettina Heidecker, Peter Libby, Vassilios S. Vassiliou, François Roubille, Orly Vardeny , et al. · 2025

Vaccination is increasingly acknowledged as an effective preventive measure not only against specific infections, but also for the prevention of cardiovascular disease in high-risk patients. Specifically, a growing body of evidence suggest…

Adjustment of the SMART risk score by bioactive adrenomedullin enables a more accurate prediction of mortality in patients with ASCVD Open

Berkan Kurt, Matthias Rau, Oliver Hartmann, Andreas Bergmann, Martin Reugels , et al. · 2025

Bio-ADM levels are independently associated with mortality and provide incremental added value on top of the SMART risk score in stable patients with ASCVD.

TAVI or TAVR: it is time to use a single standardized acronym for percutaneous aortic valve implantation Open

Ciro Indolfi, Giovanni Esposito, Thomas F. Lüscher · 2025

Evolving concepts of low‐density lipoprotein: From structure to function Open

Chu‐Huang Chen, Tatsuya Sawamura, Alexander Akhmedov, Ming‐Hsien Tsai, Ömer Akyol , et al. · 2025

Background Low‐density lipoprotein (LDL) is a central player in atherogenesis and has long been referred to as ‘bad cholesterol.’ However, emerging evidence indicates that LDL functions in multifaceted ways beyond cholesterol transport tha…

Roadmap for alleviating the manifestations of ageing in the cardiovascular system Open

Luca Liberale, Simon Tual‐Chalot, Simon Sedej, Stefano Ministrini, Georgios Georgiopoulos , et al. · 2025

The revolution in pharmacotherapy: from herbs to pills, moulds, antibodies to genetic tools Open

Thomas F. Lüscher · 2025

Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland Open

A Boudon, Isabella Locatelli, Bariş Gencer, David Carballo, Roland Klingenberg , et al. · 2025

Objectives To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS). Design Prospective cohort study from the Special Program University …

Conduction System Diseases—Cardiac Arrhythmias Open

Jan Steffel, Thomas F. Lüscher · 2025

Arterial Hypertension Open

Felix Mahfoud, Roland E. Schmieder, Thomas F. Lüscher · 2025

Artificial Intelligence Methods to Detect Heart Failure with Preserved Ejection Fraction (AIM-HFpEF) within Electronic Health Records: An equitable disease prediction model Open

Jack Wu, Dhruva Biswas, Sam P. Brown, M. J. Ryan, Brett Bernstein , et al. · 2024

Background and aims Heart Failure with Preserved Ejection Fraction (HFpEF) accounts for approximately half of all heart failure cases, with high levels of morbidity and mortality. However, most cases of HFpEF are undiagnosed as conventiona…

Endothelial JCAD Worsens Acute Ischemic Stroke Outcomes by Enhancing Inflammation in Response to Ischemia/Reperfusion Open

Stefano Ministrini, Yustina M. Puspitasari, Georgia Beer, Lena Schwarz, R Niederberger , et al. · 2024

The role of junctional protein associated with coronary artery disease (JCAD) in acute ischemic stroke (AIS) has not been investigated yet. To investigate its potential as a therapeutic target, transient middle cerebral artery occlusion wa…

An Audit of Recyclable and Contaminated Waste From Invasive Cardiac Procedures Open

Haitham Amin, Nooraldaem Yousif, Thomas F. Lüscher · 2024

The cardiologist in the age of artificial intelligence: what is left for us? Open

Thomas F. Lüscher, Florian A. Wenzl · 2024

ESC President 2024 Interview: Thomas Lüscher Open

Thomas F. Lüscher · 2024

From a club of friends to an institution: past successes and future challenges for the European Society of Cardiology Open

Thomas F. Lüscher · 2024

Sex-specific prediction of cardiogenic shock after acute coronary syndromes: the SEX-SHOCK score Open

Yifan Wang, Marianne Zeller, Vincent Auffret, Georgios Georgiopoulos, Lorenz Räber , et al. · 2024

Background and Aims Cardiogenic shock (CS) remains the primary cause of in-hospital death after acute coronary syndromes (ACS), with its plateauing mortality rates approaching 50%. To test novel interventions, personalized risk prediction …

Biomarker-enhanced cardiovascular risk prediction in patients with cancer: a prospective cohort study Open

Simon Kraler, Luca Liberale, Stephan Nopp, Cornelia Englisch, Ella Grilz , et al. · 2024

Proenkephalin improves cardio-renal risk prediction in acute coronary syndromes: the KID-ACS score Open

Florian A. Wenzl, Peizhi Wang, Mattia Arrigo, Jiří Pařenica, Donald J. L. Jones , et al. · 2024

Background and Aims Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in p…

Trajectories of cardiovascular ageing—from molecular mechanisms to clinical implementation Open

Stefano Ministrini, Florian A. Wenzl, Thomas F. Lüscher, Giovanni G. Camici · 2024

Due to its peculiar structure and function, the cardiovascular system is particularly vulnerable to the detrimental effects of ageing. Current knowledge about the molecular mechanisms of ageing revealed the processes actively promoting age…

Thomas F. Lüscher YOU? Author Swipe