Thomas F. Wulff
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View article: Targeting the translation machinery: The RNase Y specificity factor Y-complex coordinates ribosome degradation
Targeting the translation machinery: The RNase Y specificity factor Y-complex coordinates ribosome degradation Open
Limiting the synthesis and activity of ribosomes is crucial for responding to various stresses, including nutrient starvation or proteotoxic stress. In Bacillus subtilis, this can be achieved through the coordinated action of the alarmones…
View article: Novel assembly of the SF370 strain of the important human pathogen <i>Streptococcus pyogenes</i> serotype M1
Novel assembly of the SF370 strain of the important human pathogen <i>Streptococcus pyogenes</i> serotype M1 Open
The important human pathogen Streptococcus pyogenes causes a wide range of diseases. Strain SF370 was the first fully sequenced strain of S. pyogenes , providing essential insights into the molecular mechanisms of disease. We present an im…
View article: Dynamics of diversified A-to-I editing in <i>Streptococcus pyogenes</i> is governed by changes in mRNA stability
Dynamics of diversified A-to-I editing in <i>Streptococcus pyogenes</i> is governed by changes in mRNA stability Open
Adenosine-to-inosine (A-to-I) RNA editing plays an important role in the post-transcriptional regulation of eukaryotic cell physiology. However, our understanding of the occurrence, function and regulation of A-to-I editing in bacteria rem…
View article: Expanding the genetic toolbox for the obligate human pathogen Streptococcus pyogenes
Expanding the genetic toolbox for the obligate human pathogen Streptococcus pyogenes Open
Genetic tools form the basis for the study of molecular mechanisms. Despite many recent advances in the field of genetic engineering in bacteria, genetic toolsets remain scarce for non-model organisms, such as the obligatory human pathogen…
View article: Expanding the genetic toolbox for the obligate human pathogen<i>Streptococcus pyogenes</i>
Expanding the genetic toolbox for the obligate human pathogen<i>Streptococcus pyogenes</i> Open
Genetic tools form the basis for the study of molecular mechanisms. Despite many recent advances in the field of genetic engineering in bacteria, genetic toolsets remain scarce for non-model organisms, such as the obligatory human pathogen…
View article: Dynamics of diversified A-to-I editing in<i>Streptococcus pyogenes</i>is governed by changes in mRNA stability
Dynamics of diversified A-to-I editing in<i>Streptococcus pyogenes</i>is governed by changes in mRNA stability Open
Adenosine-to-inosine (A-to-I) RNA editing plays an important role in the post-transcriptional regulation of eukaryotic cell physiology. However, our understanding of the occurrence, function and regulation of A-to-I editing in bacteria rem…
View article: Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis
Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis Open
View article: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis
Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis Open
View article: A central role of glutamine in <i>Chlamydia</i> infection
A central role of glutamine in <i>Chlamydia</i> infection Open
Obligate intracellular bacteria like Chlamydia trachomatis undergo a complex developmental cycle between infectious non-replicative (EBs) and non-infectious replicative (RBs) forms. EBs shortly after entering a host cell transform to RBs, …
View article: Detection of a Subset of Posttranscriptional Transfer RNA Modifications <i>in Vivo</i> with a Restriction Fragment Length Polymorphism-Based Method
Detection of a Subset of Posttranscriptional Transfer RNA Modifications <i>in Vivo</i> with a Restriction Fragment Length Polymorphism-Based Method Open
Transfer RNAs (tRNAs) are among the most heavily modified RNA species. Posttranscriptional tRNA modifications (ptRMs) play fundamental roles in modulating tRNA structure and function and are being increasingly linked to human physiology an…