Tim Frenzel
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View article: Safety of changes in the conditions of use and the specifications of edible Jatropha curcas L. (Chuta) as a novel food pursuant to Regulation (EU) 2015/2283
Safety of changes in the conditions of use and the specifications of edible Jatropha curcas L. (Chuta) as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the changes in the conditions of use and the specifications of the hydrothermally treate…
View article: Safety of rapeseed protein–fibre concentrate as a novel food pursuant to Regulation (EU) 2015/2283
Safety of rapeseed protein–fibre concentrate as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of rapeseed protein‐fibre concentrate as a novel food (NF) pursuant to Regula…
View article: Safety of an extension of use of pasteurised Akkermansia muciniphila as a novel food pursuant to Regulation (EU) 2015/2283
Safety of an extension of use of pasteurised Akkermansia muciniphila as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an extension of use of pasteurised Akkermansia muciniphila as a novel food…
View article: Effects of angiotensin 2 infusion on the RAAS and alternative RAAS pathway
Effects of angiotensin 2 infusion on the RAAS and alternative RAAS pathway Open
Contains fulltext : 322234.pdf (Publisher’s version ) (Open Access)
View article: Safety of rhamnogalacturonan‐I enriched carrot fibre (cRG‐I) as a novel food pursuant to Regulation (EU) 2015/2283
Safety of rhamnogalacturonan‐I enriched carrot fibre (cRG‐I) as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on rhamnogalacturonan‐I enriched carrot fibre (cRG‐I) as a novel food (NF) pursuant to Regu…
View article: Safety of synthetic cannabidiol as a novel food pursuant to Regulation (EU) 2015/2283
Safety of synthetic cannabidiol as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on synthetic cannabidiol as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF…
View article: Population pharmacokinetics and optimized dosing of cefuroxime in critically ill patients
Population pharmacokinetics and optimized dosing of cefuroxime in critically ill patients Open
Cefuroxime is a second‐generation cephalosporin widely used in the intensive care unit (ICU). ICU patients have high variability in interpatient pharmacokinetics (PK), but the extent of this variation is unclear. We performed an observatio…
View article: Safety of D‐allulose as a novel food pursuant to Regulation (EU) 2015/2283
Safety of D‐allulose as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on D‐allulose as a novel food (NF) pursuant to Regulation (EU) 2015/2283. During the risk a…
View article: Safety of Clostridium butyricum TO‐A as a novel food pursuant to Regulation (EU) 2015/2283
Safety of Clostridium butyricum TO‐A as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on Clostridium butyricum TO‐A as a novel food (NF) pursuant to Regulation (EU) 2015/2283. T…
View article: Safety of yellow tomato extract as a novel food pursuant to Regulation (EU) 2015/2283
Safety of yellow tomato extract as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on yellow tomato extract used as a novel food (NF) pursuant to Regulation (EU) 2283/2015. T…
View article: Hemodynamic effects of adjunct arginine vasopressin to norepinephrine in septic shock: insights from a prospective multicenter registry study
Hemodynamic effects of adjunct arginine vasopressin to norepinephrine in septic shock: insights from a prospective multicenter registry study Open
View article: Safety of the extension of use of 3-fucosyllactose (3-FL) as a novel food pursuant to Regulation (EU) 2015/2283.
Safety of the extension of use of 3-fucosyllactose (3-FL) as a novel food pursuant to Regulation (EU) 2015/2283. Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of the extension of use of 3-fucosyllactose (3-FL) as a novel food (NF) pursu…
View article: Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283
Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to provide an opinion on the safety of a change of the specifications of the authorised NF ‘phytosterols/phytosta…
View article: Safety of frozen and dried forms of whole yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283
Safety of frozen and dried forms of whole yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283 Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of frozen, dried and powder forms of whole yellow mealworm (Tenebrio molitor …
View article: Safety of frozen, dried and powder forms of house crickets (Acheta domesticus) as a novel food pursuant
Safety of frozen, dried and powder forms of house crickets (Acheta domesticus) as a novel food pursuant Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of frozen, dried and powder forms of house crickets (Acheta domesticus) as a …
View article: The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study
The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study Open
The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (…
View article: Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the consecutive stages of the COVID-19 pandemic in the Netherlands, an update
Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the consecutive stages of the COVID-19 pandemic in the Netherlands, an update Open
Background Previously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during the final upsurge of the second wave (February–June 2021) in the Netherlands. We examined whether this decrease …
View article: Development and evaluation of regression tree models for predicting in-hospital mortality of a national registry of COVID-19 patients over six pandemic surges
Development and evaluation of regression tree models for predicting in-hospital mortality of a national registry of COVID-19 patients over six pandemic surges Open
View article: Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry
Long-term mortality of Dutch COVID-19 patients admitted to the intensive care medicine: a retrospective analysis from a national quality registry Open
Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, the total COVID-19 population and various subgroups on the basis of the number of comorbidities, age, sex, mechanical ventilation, and vasoactive…
View article: Mortalidade em longo prazo de pacientes holandeses com COVID-19 internados em terapia intensiva: análise retrospectiva de um registro nacional de qualidade
Mortalidade em longo prazo de pacientes holandeses com COVID-19 internados em terapia intensiva: análise retrospectiva de um registro nacional de qualidade Open
RESUMO Objetivo: Descrever a mortalidade em 12 meses de pacientes holandeses com COVID-19 internados em unidades de terapia intensiva, a população total com COVID-19 e vários subgrupos segundo o número de comorbidades, idade, sexo, ventila…
View article: Open Versus Closed Suctioning in Invasively Ventilated Critically Ill Patients for Sustainability of ICU Care: A Life-Cycle Assessment Comparison
Open Versus Closed Suctioning in Invasively Ventilated Critically Ill Patients for Sustainability of ICU Care: A Life-Cycle Assessment Comparison Open
Contains fulltext : 307432.pdf (Publisher’s version ) (Open Access)
View article: Automated identification of patient subgroups: A case-study on mortality of COVID-19 patients admitted to the ICU
Automated identification of patient subgroups: A case-study on mortality of COVID-19 patients admitted to the ICU Open
View article: Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning
Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning Open
View article: Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records
Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records Open
View article: INCIDENCE, RISK FACTORS, AND OUTCOME OF SUSPECTED CENTRAL VENOUS CATHETER-RELATED INFECTIONS IN CRITICALLY ILL COVID-19 PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY
INCIDENCE, RISK FACTORS, AND OUTCOME OF SUSPECTED CENTRAL VENOUS CATHETER-RELATED INFECTIONS IN CRITICALLY ILL COVID-19 PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY Open
Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patien…
View article: Safety of iron milk proteinate as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of iron from this source in the context of Directive 2002/46/EC
Safety of iron milk proteinate as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of iron from this source in the context of Directive 2002/46/EC Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on iron milk proteinate as a novel food (NF) pursuant to Regulation (EU) 2015/2283 and to a…
View article: Optimizing an existing prediction model for quality of life one‐year post‐intensive care unit: An exploratory analysis
Optimizing an existing prediction model for quality of life one‐year post‐intensive care unit: An exploratory analysis Open
Background This study aimed to improve the PREPARE model, an existing linear regression prediction model for long‐term quality of life (QoL) of intensive care unit (ICU) survivors by incorporating additional ICU data from patients' electro…
View article: Correction to: An Integral Pharmacokinetic Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients
Correction to: An Integral Pharmacokinetic Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients Open
View article: Safety of zinc l‐carnosine as a Novel food pursuant to Regulation (EU) 2015/2283 and the bioavailability of zinc from this source in the context of Directive 2002/46/EC on food supplements
Safety of zinc l‐carnosine as a Novel food pursuant to Regulation (EU) 2015/2283 and the bioavailability of zinc from this source in the context of Directive 2002/46/EC on food supplements Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on zinc l-carnosine as a novel food (NF) pursuant to Regulation (EU) 2015/2283 and as a sou…
View article: Safety of vitamin D2 mushroom powder as a Novel food pursuant to Regulation (EU) 2015/2283 (NF 2019/1471)
Safety of vitamin D2 mushroom powder as a Novel food pursuant to Regulation (EU) 2015/2283 (NF 2019/1471) Open
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on vitamin D2 mushroom powder as a novel food (NF) pursuant to Regulation (EU) 2…