Thomas Fréret
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View article: Bilateral vestibulopathy affects spatial and temporal perception
Bilateral vestibulopathy affects spatial and temporal perception Open
This study assessed impairments in spatial and temporal perception in individuals with bilateral vestibulopathy (BVP). A total of 30 BVP subjects and 35 healthy controls (CTL) participated in a series of tests to assess their perception of…
View article: LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment
LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment Open
Introduction The concept of cognitive resilience (CR) has emerged to explain the lack of correlation between the extent of brain lesions and the severity of cognitive symptoms in Alzheimer’s disease (AD), but the underlying mechanisms rema…
View article: Sexual Dimorphism of Synaptic Plasticity Changes in CA1 Hippocampal Networks in Hypergravity-Exposed Mice—New Insights for Cognition in Space
Sexual Dimorphism of Synaptic Plasticity Changes in CA1 Hippocampal Networks in Hypergravity-Exposed Mice—New Insights for Cognition in Space Open
Background: We recently reported sex-dependent impairment in cognitive functions in male and female mice exposed for 24 h, 48 h or 15 days to 2G hypergravity (HG). Methods: In the present study, we investigated brain functional correlates …
View article: Early involvement of D-serine in β-amyloid-dependent pathophysiology
Early involvement of D-serine in β-amyloid-dependent pathophysiology Open
The N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) is a key regulator of brain plasticity encoding learning and memory. In addition to glutamate, NMDAR activation requires the binding of the co-agonist D-serine. The beta-amylo…
View article: Changes in Low-Dose Aspirin Use After Updated Guidance on Sociodemographic Risk Factors for Preeclampsia
Changes in Low-Dose Aspirin Use After Updated Guidance on Sociodemographic Risk Factors for Preeclampsia Open
OBJECTIVE: To assess whether the modifications to the U.S. Preventive Services Task Force (USPSTF) and American College of Obstetricians and Gynecologists (ACOG) guidelines that emphasize “lower income” status and Black racial identity (as…
View article: Vestibular stimulation and space-time interaction affect the perception of time during whole-body rotations
Vestibular stimulation and space-time interaction affect the perception of time during whole-body rotations Open
Among the factors, such as emotions, that distort time perception, vestibular stimulation causes a contraction in subjective time. Unlike emotions, the intensity of vestibular stimulation can be easily and precisely modified, making it pos…
View article: A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits
A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits Open
Background/Objectives: Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of neurodevelopmental disorders is…
View article: Blood Biomarker Signatures for Slow Gait Speed in Older Adults: An Explainable Machine Learning Approach
Blood Biomarker Signatures for Slow Gait Speed in Older Adults: An Explainable Machine Learning Approach Open
Maintaining physical function is crucial for independent living in older adults, with gait speed being a key predictor of health outcomes. Blood biomarkers may potentially monitor older adults' mobility, yet their association with slow gai…
View article: Pharmacokinetic validation of a new protocol of chronic oral administration of aripiprazole in male C57 Bl/6 mice through drinking solution
Pharmacokinetic validation of a new protocol of chronic oral administration of aripiprazole in male C57 Bl/6 mice through drinking solution Open
Schizophrenia is a chronic mental illness, with a prevalence of about 1%. The symptoms are classified in three categories: positive symptoms, negative symptoms and deficits in cognitive function. Regarding the pharmacological treatment, cu…
View article: Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury?
Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury? Open
Background Radiotherapy is a major therapeutic approach in patients with brain tumors. However, it leads to cognitive impairments. To improve the management of radiation-induced brain sequalae, deformation-based morphometry (DBM) could be …
View article: Regional Variation in Antenatal Late Preterm Steroid Use Following the ALPS Trial
Regional Variation in Antenatal Late Preterm Steroid Use Following the ALPS Trial Open
Importance The publication of the Antenatal Late Preterm Steroids (ALPS) trial in February 2016 demonstrated that antenatal administration of betamethasone in the late preterm period (between 34 to 36 weeks of gestation) for individuals wi…
View article: A Dual-Task Paradigm Combining Physical and Cognitive Training in Mice: Application to Aging
A Dual-Task Paradigm Combining Physical and Cognitive Training in Mice: Application to Aging Open
Physical Activity (PA) is often associated with better overall health status, especially in older adults. Numerous pieces of evidence indicate that PA would be more beneficial when applied in conjunction with Cognitive Training (CT) either…
View article: 5-HT6 Receptors Sex-Dependently Modulate Hippocampal Synaptic Activity through GABA Inhibition
5-HT6 Receptors Sex-Dependently Modulate Hippocampal Synaptic Activity through GABA Inhibition Open
The subtype 6 of the serotoninergic receptors (5-HT6Rs) is highly expressed in the hippocampus, and evidence indicates the beneficial effects of 5-HT6Rs blockade on short- and long-term memory in rodents. Nevertheless, the underlying funct…
View article: Genetic Background Influence on Hippocampal Synaptic Plasticity: Frequency-Dependent Variations between an Inbred and an Outbred Mice Strain
Genetic Background Influence on Hippocampal Synaptic Plasticity: Frequency-Dependent Variations between an Inbred and an Outbred Mice Strain Open
For almost half a century, acute hippocampal slice preparations have been widely used to investigate anti-amnesic (or promnesic) properties of drug candidates on long-term potentiation (LTP)—a cellular substrate that supports some forms of…
View article: Chronotype influence on the effects of <scp>COVID</scp>‐19 lockdown on sleep and psychological status in France
Chronotype influence on the effects of <span>COVID</span>‐19 lockdown on sleep and psychological status in France Open
Summary The present study aims to assess the influence of chronotype on lockdown‐induced effects on sleep and psychological outcomes. A total of 1671 participants were recruited in France and filled out online questionnaires about their sl…
View article: Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor-α in Healthy Aging: A Role for D-Serine?
Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor-α in Healthy Aging: A Role for D-Serine? Open
Impaired activation of the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) by D-serine is linked to cognitive aging. Whether this deregulation may be used to initiate pharmacological strategies has yet to be considered. To this…
View article: Antenatal Steroid Exposure Among Term Newborns
Antenatal Steroid Exposure Among Term Newborns Open
This cross-sectional study evaluates the association between dissemination of the Antenatal Late Preterm Steroid trial and changes in steroid exposure among term newborns.