Thomas Friedel
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View article: Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease
Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease Open
Aims/hypothesis Diabetic retinal disease (DRD) is characterised by progressive neurovascular unit (NVU) dysfunction, often occurring before visible microvascular damage. Our previous studies suggested that the accumulation of acrolein (ACR…
View article: Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats Open
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the myogenic response of the ret…
View article: The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy
The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy Open
Lipids can undergo modification as a result of interaction with reactive oxygen species (ROS). For example, lipid peroxidation results in the production of a wide variety of highly reactive aldehyde species which can drive a range of disea…
View article: Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis
Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis Open
TRPV1 and TRPV4 channels represent promising targets for therapeutic intervention in vasoproliferative diseases of the retina.