Thomas G. Hofmann
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View article: Double heterozygous pathogenic variants in BRCA2 and CHEK2 in a girl with adrenocortical carcinoma
Double heterozygous pathogenic variants in BRCA2 and CHEK2 in a girl with adrenocortical carcinoma Open
Pediatric adrenocortical tumors (pACTs) are rare endocrine neoplasms with variable prognosis, commonly associated with germline pathogenic variants (PVs) in the tumor suppressor gene TP53. Here, we report the case of a 3.1-year-old female …
View article: Double Heterozygous Pathogenic Variants in TP53 and CHEK2 in Boy with Undifferentiated Embryonal Sarcoma of the Liver
Double Heterozygous Pathogenic Variants in TP53 and CHEK2 in Boy with Undifferentiated Embryonal Sarcoma of the Liver Open
Undifferentiated embryonal sarcoma of the liver is a rare mesenchymal malignancy that predominantly occurs in children. The relationship between this tumor entity and germline pathogenic variants (PVs) remains undefined. Here, we present t…
View article: The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence
The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence Open
Cellular senescence, a major driver of aging, can be stimulated by DNA damage, and is counteracted by the DNA repair machinery. Here we show that in p16INK4a-deficient cells, senescence induction by the environmental genotoxin B[a]P or ion…
View article: Puzzling phenomenon: adult-onset cancer predisposition and pediatric cancer
Puzzling phenomenon: adult-onset cancer predisposition and pediatric cancer Open
View article: Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells Open
View article: Simultaneous <i>Nbs1</i> and <i>p53</i> inactivation in neural progenitors triggers high‐grade gliomas
Simultaneous <i>Nbs1</i> and <i>p53</i> inactivation in neural progenitors triggers high‐grade gliomas Open
Aims Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disorder caused by hypomorphic mutations of NBS1. NBS1 is a member of the MRE11‐RAD50‐NBS1 (MRN) complex that binds to DNA double‐strand breaks and activates the DNA damag…
View article: Supplementary Data, Figure S1 - S3 from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
Supplementary Data, Figure S1 - S3 from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death Open
Figure S1: HIPK2 does not affect TMZ-induced senescence. Figure S2: HIPK2 does not contribute to CCNU-induced apoptosis. Figure S3: Expression of HIPK2 in LN-229 cells following treatment with TMZ in the absence and presence of the ATM inh…
View article: Data from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
Data from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death Open
Patients suffering from glioblastoma have a dismal prognosis, indicating the need for new therapeutic targets. Here we provide evidence that the DNA damage kinase HIPK2 and its negative regulatory E3-ubiquitin ligase SIAH1 are critical fac…
View article: Data from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
Data from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death Open
Patients suffering from glioblastoma have a dismal prognosis, indicating the need for new therapeutic targets. Here we provide evidence that the DNA damage kinase HIPK2 and its negative regulatory E3-ubiquitin ligase SIAH1 are critical fac…
View article: Supplementary Data, Figure S1 - S3 from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
Supplementary Data, Figure S1 - S3 from The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death Open
Figure S1: HIPK2 does not affect TMZ-induced senescence. Figure S2: HIPK2 does not contribute to CCNU-induced apoptosis. Figure S3: Expression of HIPK2 in LN-229 cells following treatment with TMZ in the absence and presence of the ATM inh…
View article: Data from Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2
Data from Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2 Open
Natural killer (NK) cells are immune cells sensing and eliminating foreign, stressed, transformed, and senescent cells through specialized surface receptors, such as NKG2D, that interacts with several virus- or stress-inducible ligands, in…
View article: Data from Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2
Data from Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2 Open
Natural killer (NK) cells are immune cells sensing and eliminating foreign, stressed, transformed, and senescent cells through specialized surface receptors, such as NKG2D, that interacts with several virus- or stress-inducible ligands, in…
View article: Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells Open
Introduction Posttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred t…
View article: Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair
Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair Open
The DNA damage response (DDR) is essential to maintain genome stability, and its deregulation predisposes to carcinogenesis while encompassing attractive targets for cancer therapy. Chromatin governs the DDR via the concerted interplay amo…
View article: p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol Open
View article: Regulating the p53 Tumor Suppressor Network at PML Biomolecular Condensates
Regulating the p53 Tumor Suppressor Network at PML Biomolecular Condensates Open
By forming specific functional entities, nuclear biomolecular condensates play an important function in guiding biological processes. PML biomolecular condensates, also known as PML nuclear bodies (NBs), are macro-molecular sub-nuclear org…
View article: Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression
Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression Open
View article: Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division Open
View article: Dose response to methylating agents in the γH2AX, SCE and colony formation assays: Effect of MGMT and MPG overexpression
Dose response to methylating agents in the γH2AX, SCE and colony formation assays: Effect of MGMT and MPG overexpression Open
Cells have developed diverse protective mechanisms that enable them to tolerate low doses of genotoxic compounds. DNA repair processes attenuate the mutagenic and carcinogenic effects of alkylating agents, and multiple studies indicate a k…
View article: Ferroptosis Meets Cell–Cell Contacts
Ferroptosis Meets Cell–Cell Contacts Open
Ferroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important …
View article: The gut microbiota instructs the hepatic endothelial cell transcriptome
The gut microbiota instructs the hepatic endothelial cell transcriptome Open
View article: Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair
Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair Open
SUMMARY The DNA damage response (DDR) is essential to maintain genome stability, and its deregulation predisposes to carcinogenesis while encompassing attractive targets for cancer therapy. Chromatin governs the DDR via the concerted inter…
View article: The Role of p53 Signaling in Colorectal Cancer
The Role of p53 Signaling in Colorectal Cancer Open
The transcription factor p53 functions as a critical tumor suppressor by orchestrating a plethora of cellular responses such as DNA repair, cell cycle arrest, cellular senescence, cell death, cell differentiation, and metabolism. In unstre…
View article: DAZAP2 acts as specifier of the p53 response to DNA damage
DAZAP2 acts as specifier of the p53 response to DNA damage Open
The DNA damage-responsive tumor suppressors p53 and HIPK2 are well established regulators of cell fate decision-making and regulate the cellular sensitivity to DNA-damaging drugs. Here, we identify Deleted in Azoospermia-associated protein…
View article: Correction: ATRIP protects progenitor cells against DNA damage in vivo
Correction: ATRIP protects progenitor cells against DNA damage in vivo Open
View article: ATRIP protects progenitor cells against DNA damage in vivo
ATRIP protects progenitor cells against DNA damage in vivo Open
The maintenance of genomic stability during the cell cycle of progenitor cells is essential for the faithful transmission of genetic information. Mutations in genes that ensure genome stability lead to human developmental syndromes. Mutati…
View article: Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence
Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence Open
Transcriptional regulation of DNA repair is of outmost importance for the restoration of DNA integrity upon genotoxic stress. Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage re…
View article: Pancreatic Ductal Adenocarcinoma (PDAC) Organoids: The Shining Light at the End of the Tunnel for Drug Response Prediction and Personalized Medicine
Pancreatic Ductal Adenocarcinoma (PDAC) Organoids: The Shining Light at the End of the Tunnel for Drug Response Prediction and Personalized Medicine Open
Pancreatic ductal adenocarcinoma (PDAC) represents 90% of pancreatic malignancies. In contrast to many other tumor entities, the prognosis of PDAC has not significantly improved during the past thirty years. Patients are often diagnosed to…
View article: Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome
Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome Open
Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress respons…
View article: ATRIP protects progenitor cells against DNA damage<i>in vivo</i>
ATRIP protects progenitor cells against DNA damage<i>in vivo</i> Open
The maintenance of genomic stability during the cell cycle of progenitor cells is essential for the faithful transmission of genetic information. Mutations in genes that ensure genome stability lead to human developmental syndromes. Mutati…