Thomas Gräff
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View article: High time to update statistical guidance in ecotoxicology—a workshop synthesis on the revision of OECD document no. 54
High time to update statistical guidance in ecotoxicology—a workshop synthesis on the revision of OECD document no. 54 Open
The Organisation for Economic Co-operation and Development (OECD) document No. 54 provides assistance on the statistical analysis of ecotoxicity data to ensure scientifically robust and globally harmonized evaluations of biotests across va…
View article: Tracing PCB contamination in fish using shadow profiles and self-organizing maps
Tracing PCB contamination in fish using shadow profiles and self-organizing maps Open
We traced the origins of contamination with polychlorinated biphenyls (PCB) in fish by mapping PCB profiles, whereby profiles represented congener fractions of the total ICES-7-PCB concentrations. 'Shadow profiles' were modelled using publ…
View article: Analysis and modelling of profiles to understand fractionation processes for contaminations with polychlorinated biphenyls observed in fish
Analysis and modelling of profiles to understand fractionation processes for contaminations with polychlorinated biphenyls observed in fish Open
Polychlorinated biphenyls (PCB) both continue to spread into the environment and to bioaccumulate from primary urban and industrial sources as well as from secondary sources such as soils and the oceans. Fractions of congeners in PCB mixtu…
View article: LogD-based modelling and ΔlogD as a proxy for pH-dependent action of ionizable chemicals reveal the relevance of both neutral and ionic species for fish embryotoxicity and possess great potential for practical application in the regulation of chemicals
LogD-based modelling and ΔlogD as a proxy for pH-dependent action of ionizable chemicals reveal the relevance of both neutral and ionic species for fish embryotoxicity and possess great potential for practical application in the regulation of chemicals Open
Depending on the ambient pH, ionizable substances are present in varying proportions in their neutral or charged form. The extent to which these two chemical species contribute to the pH-dependant toxicity of ionizable chemicals and whethe…
View article: ConsumerCheck: A Software for Analysis of Sensory and Consumer Data
ConsumerCheck: A Software for Analysis of Sensory and Consumer Data Open
ConsumerCheck is an open source data analysis software tailored for analysis of sensory and consumer data. Since some of the implemented methods are generic, such as PCA, PLSR and PCR, other data from other domains may also be analysed wit…
View article: Heart rate as an early warning parameter and proxy for subsequent mortality in Danio rerio embryos exposed to ionisable substances
Heart rate as an early warning parameter and proxy for subsequent mortality in Danio rerio embryos exposed to ionisable substances Open
Environmental risk assessments of organic chemicals usually do not consider pH as a key factor. Hence, most substances are tested at a single pH only, which may underestimate the toxicity of ionisable substances with a pKa in the range of …
View article: Better define beta–optimizing MDD (minimum detectable difference) when interpreting treatment-related effects of pesticides in semi-field and field studies
Better define beta–optimizing MDD (minimum detectable difference) when interpreting treatment-related effects of pesticides in semi-field and field studies Open
The minimum detectable difference (MDD) is a measure of the difference between the means of a treatment and the control that must exist to detect a statistically significant effect. It is a measure at a defined level of probability and a g…
View article: Simulating future salinity dynamics in a coastal marshland under different climate scenarios
Simulating future salinity dynamics in a coastal marshland under different climate scenarios Open
Salinization is a well‐known problem in agricultural areas worldwide. In the last 20–30 yr, rising salinity in the upper, unconfined aquifer has been observed in the Freepsumer Meer, a grassland near the German North Sea coast. For investi…
View article: Simulating future salinity dynamics in a coastal marshland under different climate scenarios
Simulating future salinity dynamics in a coastal marshland under different climate scenarios Open
Salinization is a well-known problem in agricultural areas worldwide. For the last 20–30 years, rising salinity in the upper, unconfined aquifer has been observed in the Freepsumer Meer, a deep grassland area near the German North Sea coas…