Thomas Gréa
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View article: Engineered biodegradables fibres for brain metal ion regulation
Engineered biodegradables fibres for brain metal ion regulation Open
Exposure to environmental heavy metals and disruptions in physiological metal homeostasis are significant contributors to neurological and neurodegenerative disorders. To counteract heavy metal toxicity, a biopolymer consisting of chitosan…
View article: Functionalization of chitosan with a polycarboxylic macrocycle yields injectable hydrogel with pH and salts responsiveness
Functionalization of chitosan with a polycarboxylic macrocycle yields injectable hydrogel with pH and salts responsiveness Open
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View article: Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies (Adv. Mater. 13/2024)
Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies (Adv. Mater. 13/2024) Open
Subcutaneous Administration of Monoclonal Antibodies Alexandre Detappe and co-workers developed a novel chitosan-based hydrogel formulation for minute-mixing with clinically approved intravenous-based monoclonal antibodies to reformulate t…
View article: Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies
Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies Open
Subcutaneous (SC) administration of monoclonal antibodies (mAbs) is a proven strategy for improving therapeutic outcomes and patient compliance. The current FDA‐/EMA‐approved enzymatic approach, utilizing recombinant human hyaluronidase (r…
View article: Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer Open
In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metal…
View article: Feasibility Study and Direct Extraction of Endogenous Free Metallic Cations Combining Hemodialysis and Chelating Polymer
Feasibility Study and Direct Extraction of Endogenous Free Metallic Cations Combining Hemodialysis and Chelating Polymer Open
In this article, we report the conception and the use of dialysis based medical device for extraction of metals. The medical device is obtained by addition in the dialysate of a functionnalized chitosan that can chelate endogenous metals l…
View article: Design of Hybrid PAH Nanoadsorbents by Surface Functionalization of ZrO2 Nanoparticles with Phosphonic Acids
Design of Hybrid PAH Nanoadsorbents by Surface Functionalization of ZrO2 Nanoparticles with Phosphonic Acids Open
This study focuses on the preparation of innovative nanocomposite materials based on surface modification of commercial nano-ZrO2 optimized from Brønsted acid–base surface reactions. This surface modification was carried out by direct graf…