Tom Greene
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View article: Liraglutide vs Semaglutide vs Dulaglutide in Veterans With Type 2 Diabetes
Liraglutide vs Semaglutide vs Dulaglutide in Veterans With Type 2 Diabetes Open
Importance The head-to-head comparative effectiveness and safety of individual glucagon-like peptide-1 receptor agonists (GLP-1RAs) are not well understood. Objective To compare risks of kidney, cardiovascular, and death outcomes among pat…
View article: Chatbot-based Intervention for Education and Access to at-home COVID-19 Testing in the SCALE-UP II Trial: a Descriptive Log Analysis Study (Preprint)
Chatbot-based Intervention for Education and Access to at-home COVID-19 Testing in the SCALE-UP II Trial: a Descriptive Log Analysis Study (Preprint) Open
BACKGROUND Promoting at-home tests (e.g., for COVID-19) using chatbots may be a novel and scalable way to improve uptake across diverse populations. OBJECTIVE The objective of this study was to assess patients’ navigational patterns (i.…
View article: Fludarabine Lymphodepletion Exposure is Associated with Toxicities after Idecabtagene-Vicleucel in Relapsed/Refractory Multiple Myeloma: Real-World Experience from the US Myeloma Immunotherapy Consortium
Fludarabine Lymphodepletion Exposure is Associated with Toxicities after Idecabtagene-Vicleucel in Relapsed/Refractory Multiple Myeloma: Real-World Experience from the US Myeloma Immunotherapy Consortium Open
Predicted Flu exposure is an independent predictor of CAR-T toxicities in this real-world ide-cel-treated population. Validation of these findings with prospective therapeutic drug monitoring is needed to gain further insight into how pers…
View article: The ELEVATE Maternal Health Center of Excellence: A Program to Reduce Maternal Morbidity From Substance Use Disorder in Utah
The ELEVATE Maternal Health Center of Excellence: A Program to Reduce Maternal Morbidity From Substance Use Disorder in Utah Open
Substance use (SU) and mental health disorders are the leading cause of maternal deaths in the United States, and individuals living in rural communities and those who identify as Native American or Alaska Native are disproportionately aff…
View article: Glycemic therapies and the risk of gastrointestinal adverse events in veterans with type 2 diabetes
Glycemic therapies and the risk of gastrointestinal adverse events in veterans with type 2 diabetes Open
Aims To compare the risk of gastrointestinal adverse events in new users of glucagon‐like peptide‐1 receptor agonists (GLP‐1RA), sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) and insulin glargine. Materials and Methods We conducted an…
View article: Population-Based Digital Health Interventions to Deliver at-Home COVID-19 Testing: SCALE-UP II Randomized Clinical Trial
Population-Based Digital Health Interventions to Deliver at-Home COVID-19 Testing: SCALE-UP II Randomized Clinical Trial Open
Background Digital health interventions could be a scalable approach to delivering at-home COVID-19 testing. Objective SCALE-UP II aimed to investigate the effectiveness of 3 digital health interventions on the delivery of mailed at-home C…
View article: Hearing Intervention, Social Isolation, and Loneliness
Hearing Intervention, Social Isolation, and Loneliness Open
Importance Promoting social connection among older adults is a public health priority. Addressing hearing loss may reduce social isolation and loneliness among older adults. Objective To describe the effect of a best-practice hearing inter…
View article: 0277 Sleep Duration, Efficiency, and Nocturnal Blood Pressure Among a Sample of Participants with Short Sleep Duration and Elevated Blood Pressure
0277 Sleep Duration, Efficiency, and Nocturnal Blood Pressure Among a Sample of Participants with Short Sleep Duration and Elevated Blood Pressure Open
Introduction Multiple aspects of sleep, including duration and efficiency, are important for blood pressure (BP) regulation and cardiovascular health. While prior research links sleep efficiency (SE) and total sleep time (TST) to BP outcom…
View article: Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula
Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula Open
The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations of wall shear stress (WSS) with subsequent AVF remodeling and clinical maturation using regression models in this prospective coho…
View article: Effect of Initiation and Continuous Adherence to ARBs Versus ACEIs on Risk of Adjudicated Mild Cognitive Impairment or Dementia
Effect of Initiation and Continuous Adherence to ARBs Versus ACEIs on Risk of Adjudicated Mild Cognitive Impairment or Dementia Open
Background Whether the differing mechanistic effects between angiotensin-2 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) on the renin-angiotensin system translate to differential effects on clinical cognitiv…
View article: Comparative effectiveness of insulin glargine, glucagon‐like peptide‐1 receptor agonists and <scp>sodium‐glucose cotransporter‐2 inhibitors</scp> in veterans with type 2 diabetes
Comparative effectiveness of insulin glargine, glucagon‐like peptide‐1 receptor agonists and <span>sodium‐glucose cotransporter‐2 inhibitors</span> in veterans with type 2 diabetes Open
Aims To compare the risk of all‐cause death and cardiovascular events in new users of insulin glargine, glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i), particularly in subgroups d…
View article: Effectiveness of shared decision making strategies for stroke prevention among patients with atrial fibrillation: cluster randomized controlled trial
Effectiveness of shared decision making strategies for stroke prevention among patients with atrial fibrillation: cluster randomized controlled trial Open
Objective To evaluate the effectiveness of multiple decision aid strategies in promoting high quality shared decision making for prevention of stroke in patients with non-valvular atrial fibrillation. Design Cluster randomized controlled t…
View article: The effect of a Veterans Affairs rapid rehousing and homelessness prevention program on long‐term housing instability
The effect of a Veterans Affairs rapid rehousing and homelessness prevention program on long‐term housing instability Open
Objective To evaluate the effect of enrolling in Supportive Services for Veteran Families (SSVF) on short‐ and long‐term housing outcomes among Veterans experiencing housing instability. Study Setting and Design We analyzed data from the D…
View article: Panel estimated Glomerular Filtration Rate (GFR): Statistical considerations for maximizing accuracy in diverse clinical populations
Panel estimated Glomerular Filtration Rate (GFR): Statistical considerations for maximizing accuracy in diverse clinical populations Open
Assessing glomerular filtration rate (GFR) is critical for diagnosis, staging, and management of kidney disease. However, accuracy of estimated GFR (eGFR) is limited by large errors (>30% error present in >10–50% of patients), adversely im…
View article: Reach and Engagement With Population Health Management Interventions to Address COVID-19 Among Safety-Net Health Care Systems
Reach and Engagement With Population Health Management Interventions to Address COVID-19 Among Safety-Net Health Care Systems Open
Interventions designed to address COVID-19 needed to be rapidly scaled up to the population level, and to address health equity by reaching historically marginalized populations most affected by the pandemic (e.g., racial/ethnic minorities…
View article: Vascular Endothelial Growth Factor–B Blockade with CSL346 in Diabetic Kidney Disease
Vascular Endothelial Growth Factor–B Blockade with CSL346 in Diabetic Kidney Disease Open
Key Points The vascular endothelial growth factor B inhibitor CSL346 (8 or 16 mg/kg q4w) did not reduce urinary albumin-creatinine ratio at week 16 versus placebo in patients with type 2 diabetes mellitus and diabetic kidney disease. CSL34…
View article: Lifestyle, medication use, and age considerations with acne vulgaris: A prospective study
Lifestyle, medication use, and age considerations with acne vulgaris: A prospective study Open
Background Lifestyle has been associated with acne, but few studies assess how the relationship changes over time. Observational studies often overlook the effects of acne medication use and participant age in relationships with lifestyle‐…
View article: The Legacy Effect of Intensive versus Standard BP Control on the Incidence of Needing Dialysis or Kidney Transplantation
The Legacy Effect of Intensive versus Standard BP Control on the Incidence of Needing Dialysis or Kidney Transplantation Open
Key Points In the Systolic Blood Pressure Intervention Trial (SPRINT), the longer-term incidence of needing dialysis or transplantation was low and primarily associated with baseline kidney function. Rates of dialysis or transplantation we…
View article: History of stroke as a predictor of high left atrial fibrosis in patients with persistent atrial fibrillation—insight from the DECAAF II randomized trial
History of stroke as a predictor of high left atrial fibrosis in patients with persistent atrial fibrillation—insight from the DECAAF II randomized trial Open
Background There is a strong relationship between left atrial (LA) remodeling and ischemic stroke (IS) risk in atrial fibrillation (AF) patients. The Efficacy of Delayed Enhancement MRI-Guided Ablation vs. Conventional Catheter Ablation of…
View article: Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers for Advanced Chronic Kidney Disease
Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers for Advanced Chronic Kidney Disease Open
National Institutes of Health. (PROSPERO: CRD42022307589).
View article: Association between Acute Declines in eGFR during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes
Association between Acute Declines in eGFR during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes Open
Key Points Renin-angiotensin system inhibition was favorable for risk of kidney failure (compared with 0% decline with use of placebo or other agents) up to declines in eGFR of 13% over a 3-month period. Relation between eGFR decline after…
View article: A multicenter randomized trial to compare automatic versus as‐needed follow‐up for children hospitalized with common infections: The FAAN‐C trial protocol
A multicenter randomized trial to compare automatic versus as‐needed follow‐up for children hospitalized with common infections: The FAAN‐C trial protocol Open
Introduction Physicians commonly recommend automatic primary care follow‐up visits to children being discharged from the hospital. While automatic follow‐up provides an opportunity to address postdischarge needs, the alternative is as‐need…
View article: Impact of Local Tailoring on Acute Stroke Care in 21 Disparate Emergency Departments: A Prospective Stepped Wedge Type III Hybrid Effectiveness-Implementation Study
Impact of Local Tailoring on Acute Stroke Care in 21 Disparate Emergency Departments: A Prospective Stepped Wedge Type III Hybrid Effectiveness-Implementation Study Open
BACKGROUND: Faster delivery of tPA (tissue-type plasminogen activator) results in better health outcomes for eligible patients with stroke. Standardization of stroke protocols in emergency departments (EDs) has been difficult, especially i…