Thomas Grischott
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View article: A multifaceted, targeted intervention to improve human papillomavirus vaccination rates in general practice: A pragmatic cluster-randomized controlled trial
A multifaceted, targeted intervention to improve human papillomavirus vaccination rates in general practice: A pragmatic cluster-randomized controlled trial Open
ISRCTN 55473884, first registered on 04/06/2021.
View article: Leveraging free-text diagnoses to identify patients with diabetes mellitus, obesity or dyslipidaemia – a cross-sectional study in a large Swiss primary care database
Leveraging free-text diagnoses to identify patients with diabetes mellitus, obesity or dyslipidaemia – a cross-sectional study in a large Swiss primary care database Open
BACKGROUND: Electronic medical records (EMRs) in general practice provide various methods for identifying patients with specific diagnoses. While several studies have focused on case identification via structured EMR components, diagnoses …
View article: The effectiveness of a multi-domain electronic feedback report on the performance of quality indicators for chronic conditions: Protocol for a randomized controlled trial in general practice
The effectiveness of a multi-domain electronic feedback report on the performance of quality indicators for chronic conditions: Protocol for a randomized controlled trial in general practice Open
Background Chronic conditions are a significant public health concern due to their rising prevalence, association with high mortality, and substantial healthcare costs. General practitioners play a crucial role in managing these conditions…
View article: Blood pressure control and antihypertensive treatment in Swiss general practice: a cross-sectional study using routine data
Blood pressure control and antihypertensive treatment in Swiss general practice: a cross-sectional study using routine data Open
AIMS OF THE STUDY: Arterial hypertension is a major global health risk. Global surveys indicate that only half of patients with arterial hypertension receive pharmacotherapy, and only a quarter achieve the primary blood pressure target rec…
View article: Potentially Inappropriate Medication Use in Primary Care in Switzerland
Potentially Inappropriate Medication Use in Primary Care in Switzerland Open
Importance Potentially inappropriate medication (PIM) exposes patients to an increased risk of adverse outcomes. Many lists of explicit criteria provide guidance on identifying PIM and recommend alternative prescribing, but the complexity …
View article: Late presentation for hepatitis C treatment: prevalence and risk factors in the Swiss Hepatitis C Cohort
Late presentation for hepatitis C treatment: prevalence and risk factors in the Swiss Hepatitis C Cohort Open
Objective Patients with ‘late presentation’ (LP) of chronic hepatitis C infection (HCV) have already developed advanced liver disease before receiving direct-acting antiviral (DAA) treatment. Even after successful treatment, the risk of mo…
View article: Procedure Prioritization During a Nationwide Ban on Non-Urgent Healthcare: A Quasi-Experimental Retrospective Study of Hospital Data in Switzerland
Procedure Prioritization During a Nationwide Ban on Non-Urgent Healthcare: A Quasi-Experimental Retrospective Study of Hospital Data in Switzerland Open
Background: During the COVID-19 lockdown in spring 2020, Switzerland restricted non-urgent healthcare services to safeguard capacity. While prioritization of care was supposed to be driven by medical urgency, demographic factors or economi…
View article: Additional file 1 of The Shiny Balancer - software and imbalance criteria for optimally balanced treatment allocation in small RCTs and cRCTs
Additional file 1 of The Shiny Balancer - software and imbalance criteria for optimally balanced treatment allocation in small RCTs and cRCTs Open
app.R Main application source code. helpers.R Definitions of imbalance measures. simulations.R Simulation study code. testdataset1.xlsx Data set 1 as Excel file. testdataset2.xlsx Data set 2 as Excel file. results_bin_tds1.jpg Scatterplots…
View article: Importance of different electronic medical record components for chronic disease identification in a Swiss primary care database: a cross-sectional study
Importance of different electronic medical record components for chronic disease identification in a Swiss primary care database: a cross-sectional study Open
BACKGROUND: Primary care databases collect electronic medical records with routine data from primary care patients. The identification of chronic diseases in primary care databases often integrates information from various electronic medic…
View article: Impact of a deprescribing tool on the use of sedative hypnotics among older patients: study protocol for a cluster randomised controlled trial in Swiss primary care (the HYPE trial)
Impact of a deprescribing tool on the use of sedative hypnotics among older patients: study protocol for a cluster randomised controlled trial in Swiss primary care (the HYPE trial) Open
Introduction Benzodiazepines and other sedative hypnotics (BSH) are potentially inappropriate and harmful medications in older people due to their higher susceptibility for adverse drug events. BSH prescription rates are constantly high am…
View article: Hepatitis C antibody test frequencies and positive rates in Switzerland from 2007 to 2017: a retrospective longitudinal study
Hepatitis C antibody test frequencies and positive rates in Switzerland from 2007 to 2017: a retrospective longitudinal study Open
ACKGROUND AND AIMS: The prevalence of chronic hepatitis C in Switzerland is currently estimated at approximately 32,000 affected individuals (0.37% of the permanent resident population). An estimated 40% of affected individuals in Switzerl…
View article: The Impact of COVID-19 on Mental Healthcare Utilization in Switzerland Was Strongest Among Young Females—Retrospective Study in 2018–2020
The Impact of COVID-19 on Mental Healthcare Utilization in Switzerland Was Strongest Among Young Females—Retrospective Study in 2018–2020 Open
Objectives: To provide a thorough assessment of the impact of the COVID-19 pandemic on the utilization of inpatient and outpatient mental healthcare in Switzerland. Methods: Retrospective cohort study using nationwide hospital data ( n >…
View article: Impact of the COVID-19 Pandemic on Elective and Emergency Inpatient Procedure Volumes in Switzerland – A Retrospective Study Based on Insurance Claims Data
Impact of the COVID-19 Pandemic on Elective and Emergency Inpatient Procedure Volumes in Switzerland – A Retrospective Study Based on Insurance Claims Data Open
Background: The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) pandemic forced hospitals to redistribute resources for the treatment of patients with coronavirus disease 2019 (COVID-19), yet the impact on elective and emergen…
View article: Comparison of Motivational Short Interventions to Improve Smokers’ Health Behavior (The COSMOS Study): A Pragmatic Cluster-Randomized Two-Arm Trial in General Practice
Comparison of Motivational Short Interventions to Improve Smokers’ Health Behavior (The COSMOS Study): A Pragmatic Cluster-Randomized Two-Arm Trial in General Practice Open
Introduction Helping smokers to quit is an important task of general practitioners (GPs). However, achieving tobacco abstinence is difficult, and smokers who fail may still want to improve their health in other ways. Therefore, Swiss GPs d…
View article: Prescription Rates, Polypharmacy and Prescriber Variability in Swiss General Practice—A Cross-Sectional Database Study
Prescription Rates, Polypharmacy and Prescriber Variability in Swiss General Practice—A Cross-Sectional Database Study Open
Purpose: The frequency of medication prescribing and polypharmacy has increased in recent years in different settings, including Swiss general practice. We aimed to describe patient age- and sex-specific rates of polypharmacy and of prescr…
View article: Price trends of reimbursed oncological drugs in Switzerland in 2005–2019: A descriptive analysis
Price trends of reimbursed oncological drugs in Switzerland in 2005–2019: A descriptive analysis Open
Increasing oncological treatment costs are a major global concern with the risk of entailing two-tiered health care. Among cost determining factors is the price of individual drugs. In recognition of the central role of this factor, we pre…
View article: Analysis of Launch and Postapproval Cancer Drug Pricing, Clinical Benefit, and Policy Implications in the US and Europe
Analysis of Launch and Postapproval Cancer Drug Pricing, Clinical Benefit, and Policy Implications in the US and Europe Open
During this economic evaluation study period, launch prices of cancer drugs were substantially higher in the US than in the assessed similar high-income European countries, a gap that increased in the years after approval. Cancer drug pric…
View article: Implementation of a complex intervention to improve hospital discharge: process evaluation of a cluster randomised controlled trial
Implementation of a complex intervention to improve hospital discharge: process evaluation of a cluster randomised controlled trial Open
Objectives To study the implementation of a cluster randomised controlled effectiveness-implementation hybrid trial testing the effectiveness of a medication review at hospital discharge combined with a communication stimulus between hospi…
View article: Sample size calculation using Markov chains for a one-arm study of heroin administration routes
Sample size calculation using Markov chains for a one-arm study of heroin administration routes Open
Sample size calculations for trials with time-to-event outcomes are usually based on the assumption that an event – prototypically death in survival analysis – occurs only once per sample unit. However, events like changes in disease statu…
View article: Guideline Concordance of Statin Treatment Decisions: A Retrospective Cohort Study
Guideline Concordance of Statin Treatment Decisions: A Retrospective Cohort Study Open
Guidelines recommend initiation of statins depending on cardiovascular risk and low-density lipoprotein cholesterol (LDL-C) levels. In this retrospective cohort study, we aimed to assess guideline concordance of statin treatment decisions …
View article: Commentary: Accessibility of cancer drugs in Switzerland: Time from approval to pricing decision between 2009 and 2018
Commentary: Accessibility of cancer drugs in Switzerland: Time from approval to pricing decision between 2009 and 2018 Open
GENERAL COMMENTARY article Front. Public Health, 09 September 2020Sec. Health Economics Volume 8 - 2020 | https://doi.org/10.3389/fpubh.2020.00517
View article: What interventions do general practitioners recommend avoiding? A nationwide survey from Switzerland
What interventions do general practitioners recommend avoiding? A nationwide survey from Switzerland Open
BACKGROUND To address low-value interventions in healthcare, “Choosing Wisely” campaigns provide recommendations of interventions to avoid (RIAs). These are usually developed by expert panels rather than general practitioners (GPs). The ai…
View article: General practitioners’ consultation counts and associated factors in Swiss primary care – A retrospective observational study
General practitioners’ consultation counts and associated factors in Swiss primary care – A retrospective observational study Open
Female gender, part-time work in the range of 60%-90% of full-time, and working in group practices do not decrease GP efficiency. However, the challenge of recruiting sufficient numbers of GPs remains.
View article: Improving inappropriate medication and information transfer at hospital discharge: study protocol for a cluster RCT
Improving inappropriate medication and information transfer at hospital discharge: study protocol for a cluster RCT Open
ISRCTN, ISRCTN18427377 . Registered 11 January 2018.
View article: Medical online consultation service in gastroenterology at the University Hospital Zurich
Medical online consultation service in gastroenterology at the University Hospital Zurich Open
Background: Since 1999, the University Hospital Zurich (Switzerland) offers an e-mail based online consultation where patients can ask online doctors anonymous questions about individual health concerns. This study aimed at the characteriz…