Thomas H. Charpentier
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View article: Divergent synthesis of prenylated xanthones as novel fungal IRE1 inhibitors
Divergent synthesis of prenylated xanthones as novel fungal IRE1 inhibitors Open
View article: Retrospective Analysis of the Impact of Vaccination with an Inactivated Vaccine on Toxoplasmosis-Associated Mortality in Captive Wildlife
Retrospective Analysis of the Impact of Vaccination with an Inactivated Vaccine on Toxoplasmosis-Associated Mortality in Captive Wildlife Open
Background/Objectives: Toxoplasma gondii is a major cause of zoonotic infections in both humans and animals, resulting in significant mortality in susceptible species, such as New World primates and marsupials. Toxoplasmosis is particularl…
View article: Host ZAP activity correlates with the levels of CpG suppression in primate lentiviruses
Host ZAP activity correlates with the levels of CpG suppression in primate lentiviruses Open
Zinc-finger antiviral protein (ZAP) is thought to drive the suppression of CpG dinucleotides in many viruses to mimic the composition of their host genomes. However, in vivo evidence is sparse. Here, we investigated the reasons for unusual…
View article: Xanthone Inhibitors of Unfolded Protein Response Isolated from <i>Calophyllum caledonicum</i>
Xanthone Inhibitors of Unfolded Protein Response Isolated from <i>Calophyllum caledonicum</i> Open
The unfolded protein response (UPR) is a key component of fungal virulence. The prenylated xanthone γ-mangostin isolated from Garcinia mangostana (Clusiaceae) fruit pericarp, has recently been described to inhibit this fungal adapta…
View article: Natural Products Targeting the Fungal Unfolded Protein Response as an Alternative Crop Protection Strategy
Natural Products Targeting the Fungal Unfolded Protein Response as an Alternative Crop Protection Strategy Open
Discovering new solutions for crop protection is a major challenge for the next decades as a result of the ecotoxicological impact of classical fungicides, the emergence of fungicide resistances, and the consequence of climate change on pa…
View article: Nasal vaccination of six squirrel monkeys (Saimiri sciureus): Improved immunization protocol against Toxoplasma gondii with a nanoparticle-born vaccine
Nasal vaccination of six squirrel monkeys (Saimiri sciureus): Improved immunization protocol against Toxoplasma gondii with a nanoparticle-born vaccine Open
View article: Data from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma
Data from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma Open
Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent activating mutations in the G proteins, Gαq and Gα11, are observed in app…
View article: Supplementary Figure S1 from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma
Supplementary Figure S1 from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma Open
GNAQ and GNA11 sequence analysis of UM002B cells.
View article: Data from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma
Data from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma Open
Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent activating mutations in the G proteins, Gαq and Gα11, are observed in app…
View article: Supplementary Figure S1 from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma
Supplementary Figure S1 from Effects of Oncogenic Gα<sub>q</sub> and Gα<sub>11</sub> Inhibition by FR900359 in Uveal Melanoma Open
GNAQ and GNA11 sequence analysis of UM002B cells.
View article: A Descriptive Chemical Composition of Concentrated Bud Macerates through an Optimized SPE-HPLC-UV-MS2 Method—Application to Alnus glutinosa, Ribes nigrum, Rosa canina, Rosmarinus officinalis and Tilia tomentosa
A Descriptive Chemical Composition of Concentrated Bud Macerates through an Optimized SPE-HPLC-UV-MS2 Method—Application to Alnus glutinosa, Ribes nigrum, Rosa canina, Rosmarinus officinalis and Tilia tomentosa Open
Concentrated bud macerates (CBMs) are obtained from meristematic tissues such as buds and young shoots by maceration in a solvent composed of glycerin, water and ethanol (1/1/1/, v/v). Their traditional utilization in gemmotherapy has gain…
View article: Membrane-induced Allosteric Control of Phospholipase C-β Isozymes
Membrane-induced Allosteric Control of Phospholipase C-β Isozymes Open
All peripheral membrane proteins must negotiate unique constraints intrinsic to the biological interface of lipid bilayers and the cytosol. Phospholipase C-β (PLC-β) isozymes hydrolyze the membrane lipid phosphatidylinositol 4,5-bisphospha…
View article: A Cell-Permeable Inhibitor to Trap Gαq Proteins in the Empty Pocket Conformation
A Cell-Permeable Inhibitor to Trap Gαq Proteins in the Empty Pocket Conformation Open
In spite of the crucial role of heterotrimeric G proteins as molecular switches transmitting signals from G protein-coupled receptors, their selective manipulation with small molecule, cell-permeable inhibitors still remains an unmet chall…
View article: The dog erythrocyte antigen 1 blood group in nondomesticated canids and compatibility testing between domestic dog and nondomesticated canid blood
The dog erythrocyte antigen 1 blood group in nondomesticated canids and compatibility testing between domestic dog and nondomesticated canid blood Open
Background The dog erythrocyte antigen (DEA) 1 blood group is considered as the most immunogenic and clinically important in dogs. Little is known in nondomesticated canids. Objectives To type DEA 1 in nondomesticated captive canids and to…
View article: Potent and Selective Peptide-based Inhibition of the G Protein Gαq
Potent and Selective Peptide-based Inhibition of the G Protein Gαq Open
In contrast to G protein-coupled receptors, for which chemical and peptidic inhibitors have been extensively explored, few compounds are available that directly modulate heterotrimeric G proteins. Active Gα q binds its two major classes of…
View article: Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma
Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma Open
Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent activating mutations in the G proteins, Gαq and Gα11, are observed in approximately 93% of all …
View article: Potent and Selective Peptide-based Inhibition of the G Protein Gαq
Potent and Selective Peptide-based Inhibition of the G Protein Gαq Open
View article: Small Molecule Inhibitors of Ca<sup>2+</sup>-S100B Reveal Two Protein Conformations
Small Molecule Inhibitors of Ca<sup>2+</sup>-S100B Reveal Two Protein Conformations Open
The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B·p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. However, off-target effects associated with this drug were problemati…
View article: The experimental power of FR900359 to study Gq-regulated biological processes
The experimental power of FR900359 to study Gq-regulated biological processes Open