Thomas H. McConville
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View article: Lipid A modification of colistin-resistant <i>Klebsiella pneumoniae</i> does not alter innate immune response in a mouse model of pneumonia
Lipid A modification of colistin-resistant <i>Klebsiella pneumoniae</i> does not alter innate immune response in a mouse model of pneumonia Open
Polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae bacteria is associated with high morbidity and mortality in vulnerable populations throughout the world. Ineffective antimicrobial activity by these last resort therapeutic…
View article: Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection Open
View article: Structural basis of lipopolysaccharide maturation by the O-antigen ligase
Structural basis of lipopolysaccharide maturation by the O-antigen ligase Open
View article: <i>In Vitro</i> Cytotoxicity and Clinical Correlates of MRSA Bacteremia
<i>In Vitro</i> Cytotoxicity and Clinical Correlates of MRSA Bacteremia Open
Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections are associated with significant morbidity and mortality. MRSA secretes a number of virulence factors and pore-forming toxins that enable tissue invasion.
View article: An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection
An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection Open
View article: Characterization of Bacterial and Fungal Infections in Hospitalized Patients With Coronavirus Disease 2019 and Factors Associated With Health Care-Associated Infections
Characterization of Bacterial and Fungal Infections in Hospitalized Patients With Coronavirus Disease 2019 and Factors Associated With Health Care-Associated Infections Open
Background Patients hospitalized with coronavirus disease 2019 (COVID-19) are at increased risk of health care–associated infections (HAIs), especially with prolonged hospital stays. We sought to identify incidence, antimicrobial susceptib…
View article: What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak
What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak Open
Background Tocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent of corticosteroids remains unclear in patients with severe disease. Methods In this retrospective an…
View article: An efficient and versatile CRISPR-Cas9 system for genetic manipulation of multi-drug resistant Klebsiella pneumoniae
An efficient and versatile CRISPR-Cas9 system for genetic manipulation of multi-drug resistant Klebsiella pneumoniae Open
View article: Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital
Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital Open
Background Patients with COVID-19 may be at increased risk for secondary bacterial infections with MDR pathogens, including carbapenemase-producing Enterobacterales (CPE). Objectives We sought to rapidly investigate the clinical characteri…
View article: 371. Cluster of carbapenemase-producing Enterobacterales secondary infections during the COVID-19 crisis at a New York City hospital
371. Cluster of carbapenemase-producing Enterobacterales secondary infections during the COVID-19 crisis at a New York City hospital Open
Background Patients with COVID-19 may be at increased risk for secondary bacterial infections. At our quaternary care hospital in New York City, the rapid escalation of COVID-19 cases was accompanied by a massive surge in the need for hosp…
View article: CrrB Positively Regulates High-Level Polymyxin Resistance and Virulence in Klebsiella pneumoniae
CrrB Positively Regulates High-Level Polymyxin Resistance and Virulence in Klebsiella pneumoniae Open
Epidemiology of Staphylococcus aureus in neonates on admission to a Chinese neonatal intensive care unit Open
View article: CrrB Positively Regulates High-Level Polymyxin-Resistance and Virulence in <i>Klebsiella pneumoniae</i>
CrrB Positively Regulates High-Level Polymyxin-Resistance and Virulence in <i>Klebsiella pneumoniae</i> Open
View article: Cluster of carbapenemase-producing enterobacterales secondary infections during the COVID-19 crisis at a New York City Hospital
Cluster of carbapenemase-producing enterobacterales secondary infections during the COVID-19 crisis at a New York City Hospital Open
Background: Patients with COVID-19 may be at increased risk for secondary bacterial infections At our quaternary care hospital in New York City, the rapid escalation of COVID-19 cases was accompanied by a massive surge in the need for hos…
View article: Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study
Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study Open
Background Polymyxins are antimicrobials of last resort for the treatment of carbapenem-resistant Enterobacteriaceae, but resistance in 5% to >40% isolates has been reported. We conducted a genomic survey of clinical polymyxin-resistant…
View article: 2306. Molecular Epidemiology of and Risk Factors for (SA) Colonization in a Chinese Neonatal Intensive Care Unit (NICU).
2306. Molecular Epidemiology of and Risk Factors for (SA) Colonization in a Chinese Neonatal Intensive Care Unit (NICU). Open
View article: 2306. Molecular Epidemiology of and Risk Factors for <i>Staphyloccus aureus</i> (SA) Colonization in a Chinese Neonatal Intensive Care Unit (NICU)
2306. Molecular Epidemiology of and Risk Factors for <i>Staphyloccus aureus</i> (SA) Colonization in a Chinese Neonatal Intensive Care Unit (NICU) Open
BACKGROUND: SA infections place a significant burden on NICUs worldwide. However, little is known about the burden of SA in Chinese NICUs. In this study, we describe the molecular epidemiology of SA in the tertiary care 50-bed NICU of Beiji…
View article: 707. Clarifying the Role of CrrB in Polymxyin-resistant Klebsiella pneumoniae Clinical Isolates Utilizing a Novel CRISPR-Cas9 System
707. Clarifying the Role of CrrB in Polymxyin-resistant Klebsiella pneumoniae Clinical Isolates Utilizing a Novel CRISPR-Cas9 System Open
Background Polymyxin resistance (PR) threatens the mainstay of therapy for carbapenem-resistant Enterobacteriaceae (CRE) infections. While mgrB disruption accounts for most cases of PR, missense mutations in crrB have been proposed as an a…
View article: Successive Emergence of Ceftazidime-Avibactam Resistance through Distinct Genomic Adaptations in <i>bla</i> <sub>KPC-2</sub> -Harboring Klebsiella pneumoniae Sequence Type 307 Isolates
Successive Emergence of Ceftazidime-Avibactam Resistance through Distinct Genomic Adaptations in <i>bla</i> <sub>KPC-2</sub> -Harboring Klebsiella pneumoniae Sequence Type 307 Isolates Open
Ceftazidime-avibactam (CAZ-AVI) is a promising novel treatment for infections caused by carbapenem-resistant Enterobacteriaceae (CRE). Despite improved treatment outcomes compared to those achieved with aminoglycoside- and colistin-based r…
View article: Carbapenem-resistant Enterobacteriaceae colonization (CRE) and subsequent risk of infection and 90-day mortality in critically ill patients, an observational study
Carbapenem-resistant Enterobacteriaceae colonization (CRE) and subsequent risk of infection and 90-day mortality in critically ill patients, an observational study Open
Background: Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as an urgent public health threat. Intestinal colonization with CRE has been identified as a risk factor for the development of systemic CRE infection, but has not been…
View article: Staphylococcus epidermidis Protection Against Staphylococcus aureus Colonization in People Living With Human Immunodeficiency Virus in an Inner-City Outpatient Population: A Cross-Sectional Study
Staphylococcus epidermidis Protection Against Staphylococcus aureus Colonization in People Living With Human Immunodeficiency Virus in an Inner-City Outpatient Population: A Cross-Sectional Study Open
Background People living with human immunodeficiency virus (PLWH) have been disproportionally affected by methicillin-resistant Staphylococcus aureus (MRSA) colonization and infection, in particular by clones USA300 and USA500. However, th…