Thomas Höfer
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View article: Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees
Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees Open
Multipotent progenitors (MPP) are the quantitative source of native hematopoiesis that have been thought to be replenished slowly by hematopoietic stem cells (HSC). However, recent fate mapping studies have revealed two developmentally dis…
View article: Optimizing efficacy and safety of T cell bispecific antibodies: the interdependence of CD3 and tumor antigen binder affinities in FOLR1 and CEACAM5 2 + 1 TCBs
Optimizing efficacy and safety of T cell bispecific antibodies: the interdependence of CD3 and tumor antigen binder affinities in FOLR1 and CEACAM5 2 + 1 TCBs Open
T cell bispecific antibodies (TCBs) are an emerging class of cancer therapy that are typically designed for high binding affinity to CD3 and tumor antigen (TA). Using this approach, TCBs have demonstrated significant clinical efficacy, but…
View article: Recurrent DNA Break Clusters Regulated by Polymerase Theta Are Essential for Replication Stress Induced Copy Number Variation
Recurrent DNA Break Clusters Regulated by Polymerase Theta Are Essential for Replication Stress Induced Copy Number Variation Open
Copy number variations (CNVs) are a form of genetic alteration strongly implicated in numerous neurological and psychiatric disorders, as well as brain cancer. Replication stress is a common cause of CNVs. Despite the prevailing model that…
View article: Recurrent DNA Break Clusters Regulated by Polymerase Theta Are Essential for Replication Stress Induced Copy Number Variation
Recurrent DNA Break Clusters Regulated by Polymerase Theta Are Essential for Replication Stress Induced Copy Number Variation Open
Copy number variations (CNVs) are a form of genetic alteration strongly implicated in numerous neurological and psychiatric disorders, as well as brain cancer. Replication stress is a common cause of CNVs. Despite the prevailing model that…
View article: Clonal Dynamics in the Male Germline from Development to Next Generation
Clonal Dynamics in the Male Germline from Development to Next Generation Open
Germ cells support the continuation and evolution of species. In mammals, the germline trajectory originates from a limited number of primordial germ cells (PGCs), persists through the lifespan of the organism, and continues across generat…
View article: Competitive resource allocation drives asynchronous and rapid nuclear multiplication in the malaria parasite
Competitive resource allocation drives asynchronous and rapid nuclear multiplication in the malaria parasite Open
The unicellular malaria parasite Plasmodium falciparum proliferates within the red blood cells of its human host, where it generates approximately 20 new parasites within an infection cycle of two days. Proliferation proceeds by nuclear di…
View article: Detecting and quantifying clonal selection in somatic stem cells
Detecting and quantifying clonal selection in somatic stem cells Open
As DNA variants accumulate in somatic stem cells, become selected or evolve neutrally, they may ultimately alter tissue function. When, and how, selection occurs in homeostatic tissues is incompletely understood. Here, we introduce SCIFER,…
View article: Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool
Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool Open
View article: Oncogene aberrations drive medulloblastoma progression, not initiation
Oncogene aberrations drive medulloblastoma progression, not initiation Open
View article: P-02.04 Developing T cell bispecific antibodies with reduced-affinity anti-CD3 binders for a potent, efficacious, and low-cytokine response
P-02.04 Developing T cell bispecific antibodies with reduced-affinity anti-CD3 binders for a potent, efficacious, and low-cytokine response Open
View article: Adaptive Clonal Expansion Shapes Brain Development
Adaptive Clonal Expansion Shapes Brain Development Open
Embryonic neural stem/progenitor cells (NSPCs) exhibit remarkable proliferative plasticity, allowing them to fully recover neuronal populations even after substantial cell loss 1,2 . However, it remains unclear whether all embryonic NSPCs …
View article: Author Correction: Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability
Author Correction: Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability Open
View article: Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development Open
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with computational inference, we comprehensively…
View article: Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability
Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability Open
View article: Plasticity and lineage commitment of individual T<sub>H</sub>1 cells are determined by stable T-bet expression quantities
Plasticity and lineage commitment of individual T<sub>H</sub>1 cells are determined by stable T-bet expression quantities Open
T helper 1 (T H 1) cell identity is defined by the expression of the lineage-specifying transcription factor T-bet. Here, we examine the influence of T-bet expression heterogeneity on subset plasticity by leveraging cell sorting of distinc…
View article: Network switches and their role in circadian clocks
Network switches and their role in circadian clocks Open
View article: CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy
CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy Open
Effective T-cell responses not only require the engagement of T-cell receptors (TCRs; “signal 1”), but also the availability of costimulatory signals (“signal 2”). T-cell bispecific antibodies (TCBs) deliver a robust signal 1 by engaging t…
View article: P04.01 Early recovery of radiation induced lymphopenia in NSCLC stage III lung cancer: correlation with prognosis in a prospective study
P04.01 Early recovery of radiation induced lymphopenia in NSCLC stage III lung cancer: correlation with prognosis in a prospective study Open
Background To explore the impact of dynamic changes of leukocyte subsets during therapy on patient prognosis in inoperable stage III NSCLC, we compared in a prospective explorative single-center study the kinetics of major leukocyte subset…
View article: Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance
Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance Open
Despite recent advances in understanding disease biology, treatment of Group 3/4 medulloblastoma remains a therapeutic challenge in pediatric neuro-oncology. Bulk-omics approaches have identified considerable intertumoral heterogeneity in …
View article: The population context is a driver of the heterogeneous response of epithelial cells to interferons
The population context is a driver of the heterogeneous response of epithelial cells to interferons Open
View article: A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses
A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses Open
View article: Extended methods for spatial cell classification with DBSCAN-CellX
Extended methods for spatial cell classification with DBSCAN-CellX Open
Local cell densities and positioning within cellular monolayers and stratified epithelia have important implications for cell interactions and the functionality of various biological processes. To analyze the relationship between cell loca…
View article: Population context drives cell-to-cell variability in interferon response in epithelial cells
Population context drives cell-to-cell variability in interferon response in epithelial cells Open
Isogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning approach combined with high-content imaging and spatial analyses, we characterized how the population context (position of a cell with respect to the n…
View article: MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange Open
View article: Supplementary Figure 2 from Chromothripsis in Human Breast Cancer
Supplementary Figure 2 from Chromothripsis in Human Breast Cancer Open
Copy-number differences between cases with and without chromothripsis in the CATCH cohort
View article: Table S1 from Chromothripsis in Human Breast Cancer
Table S1 from Chromothripsis in Human Breast Cancer Open
Description of the patient cohorts and available data
View article: Supplemental Figure 2 from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Supplemental Figure 2 from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors Open
Pharmacokinetic profiles of CEA TCB in mice, additional information on CD3 signaling, T cell activation, tumor cell lysis and cytokine release upon CEA TCB and untargeted control TCB treatment.
View article: Data from Chromothripsis in Human Breast Cancer
Data from Chromothripsis in Human Breast Cancer Open
Chromothripsis is a form of genome instability by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosomes. Widely assumed to be an early event in tumor development, this phenomeno…
View article: Table S5 from Chromothripsis in Human Breast Cancer
Table S5 from Chromothripsis in Human Breast Cancer Open
Recurrent fusion genes and parameters of the regression analysis
View article: Supplementary Figure 5 from Chromothripsis in Human Breast Cancer
Supplementary Figure 5 from Chromothripsis in Human Breast Cancer Open
Copy-number plots and rainfall plots for the 11 patients with two tumors from the DKFZ-HIPO17 cohort