Thomas Hübschle
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View article: Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist Open
View article: Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice
Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice Open
In the heart, the serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and the extracellular matrix (ECM). CatA-mediated degradation of extracellular peptides may contribute to ECM remodeling and left ventricular (LV…
View article: Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss
Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss Open
View article: Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion
Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion Open
View article: Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study
Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study Open
Glucagon-like peptide 1 (GLP-1) stimulated insulin secretion has a considerable heritable component as estimated from twin studies, yet few genetic variants influencing this phenotype have been identified. We performed the first genome-wid…
View article: Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels Open
View article: Brainstem metabotropic glutamate receptors reduce food intake and activate dorsal pontine and medullar structures after peripheral bacterial lipopolysaccharide administration
Brainstem metabotropic glutamate receptors reduce food intake and activate dorsal pontine and medullar structures after peripheral bacterial lipopolysaccharide administration Open
View article: Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches
Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches Open
Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease) and microvascular disorders leading to damage of the ki…