Thomas J. Humphries
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View article: Cache Me If You Can: Accuracy-Aware Inference Engine for Differentially Private Data Exploration
Cache Me If You Can: Accuracy-Aware Inference Engine for Differentially Private Data Exploration Open
Differential privacy (DP) allows data analysts to query databases that contain users' sensitive information while providing a quantifiable privacy guarantee to users. Recent interactive DP systems such as APEx provide accuracy guarantees o…
View article: Selective MPC: Distributed Computation of Differentially Private\n Key-Value Statistics
Selective MPC: Distributed Computation of Differentially Private\n Key-Value Statistics Open
Key-value data is a naturally occurring data type that has not been\nthoroughly investigated in the local trust model. Existing local differentially\nprivate (LDP) solutions for computing statistics over key-value data suffer\nfrom the inh…
View article: Understanding the Pain Management Landscape Within the US Bleeding Disorder Community: A Multi-Center Survey
Understanding the Pain Management Landscape Within the US Bleeding Disorder Community: A Multi-Center Survey Open
Objectives Pain is a known complication in persons with hemophilia (PWH) as a result of muscle and joint bleeding. Little is known regarding national Hemophilia Treatment Center (HTC) practice patterns related to pain management. The aim o…
View article: Investigating Membership Inference Attacks under Data Dependencies
Investigating Membership Inference Attacks under Data Dependencies Open
Training machine learning models on privacy-sensitive data has become a popular practice, driving innovation in ever-expanding fields. This has opened the door to new attacks that can have serious privacy implications. One such attack, the…
View article: Early prognostication of COVID-19 to guide hospitalisation versus outpatient monitoring using a point-of-test risk prediction score
Early prognostication of COVID-19 to guide hospitalisation versus outpatient monitoring using a point-of-test risk prediction score Open
Introduction Risk factors of adverse outcomes in COVID-19 are defined but stratification of mortality using non-laboratory measured scores, particularly at the time of pre-hospital SARS-CoV-2 testing, is lacking. Methods Multivariate regre…
View article: Complementary and alternative therapy (CAM) in haemophilia pain management: a review of published literature
Complementary and alternative therapy (CAM) in haemophilia pain management: a review of published literature Open
Pain continues to be a significant issue for people with haemophilia (PWH), whether it is acute pain from a joint bleed, a needle stick when receiving clotting factor treatment, or chronic pain from chronic synovitis and arthritic changes.…
View article: Point-of-care ultrasonography (POCUS) in hemophilia A: a commentary on current status and its potential role for improving prophylaxis management in severe hemophilia A
Point-of-care ultrasonography (POCUS) in hemophilia A: a commentary on current status and its potential role for improving prophylaxis management in severe hemophilia A Open
In patients with severe hemophilia A, recurrent bleeding into joints results in increased morbidity and reduced quality of life. Prophylaxis using replacement factor products, especially when initiated early, has established benefits in te…
View article: Pain in haemophilia: are we listening?
Pain in haemophilia: are we listening? Open
In September 2014, the US Food and Drug Administration (FDA) convened a public meeting titled 'Patient-Focused Drug Development for Hemophilia A, Hemophilia B, von Willebrand Disease, and Other Heritable Bleeding Disorders' 1. The purpose …
View article: A second retrospective database analysis confirms prior findings of apparent increased cardiovascular comorbidities in hemophilia <scp>A</scp> in the <scp>U</scp>nited <scp>S</scp>tates
A second retrospective database analysis confirms prior findings of apparent increased cardiovascular comorbidities in hemophilia <span>A</span> in the <span>U</span>nited <span>S</span>tates Open
The availability of replacement factor products and improvements in treatment strategies over time have led to increased life expectancy of patients with hemophilia; consequently, the incidence of age-related comorbidities has increased in…
View article: Inhibitors in haemophilia A: a perspective on clotting factor products as a potential contributing factor
Inhibitors in haemophilia A: a perspective on clotting factor products as a potential contributing factor Open
Introduction The occurrence of a neutralizing antibody in previously untreated patients ( PUP s) with haemophilia A appears to be the result of an intricate interplay of both genetic and environmental factors. Recently, the type of factor …
View article: Sucrose-Formulated Recombinant Factor VIII Dosing Flexibility in Prophylaxis Regimens: Experience from Postmarketing Surveillance Studies
Sucrose-Formulated Recombinant Factor VIII Dosing Flexibility in Prophylaxis Regimens: Experience from Postmarketing Surveillance Studies Open
Objectives . Prophylaxis regimens for severe hemophilia A allowing more flexible dosing while maintaining efficacy may improve adherence and decrease the cost of prophylaxis. Here, we compared the clinical effectiveness of once- or twice-w…