Thomas J. Hoffmann
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View article: Human-Delivered Conversation Versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States: Quasi-Experimental Studies
Human-Delivered Conversation Versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States: Quasi-Experimental Studies Open
Background Artificial intelligence (AI) chatbots, driven by advances in natural language processing, can analyze and generate human language through computational linguistics and machine learning. Despite the rapid development of large lan…
View article: Evaluating the Preliminary Efficacy of the TRUST Intervention on Alone-Time and Communication During Well-Adolescent Visits: Quasi-Experimental Study
Evaluating the Preliminary Efficacy of the TRUST Intervention on Alone-Time and Communication During Well-Adolescent Visits: Quasi-Experimental Study Open
Background Alone time with health care providers is critical for adolescents, and several professional organizations recommend it. Alone time with providers promotes better utilization of health services, empowers adolescents to manage the…
View article: AI HeartBot to Increase Women’s Awareness and Knowledge of Heart Attacks: Nonrandomized, Quasi-Experimental Study
AI HeartBot to Increase Women’s Awareness and Knowledge of Heart Attacks: Nonrandomized, Quasi-Experimental Study Open
Background Heart disease remains a leading cause of death for women in the United States, but awareness and knowledge about it are declining. Artificial intelligence (AI) chatbots have great potential to educate women. Objective This study…
View article: The potential of kidney transplantation to reduce mortality from chronic kidney disease: a global, cross-sectional, modelling study
The potential of kidney transplantation to reduce mortality from chronic kidney disease: a global, cross-sectional, modelling study Open
None.
View article: Whole Exome Sequencing Study Uncovers Novel Candidate Genes and Protein-Coding Variants for Cataract
Whole Exome Sequencing Study Uncovers Novel Candidate Genes and Protein-Coding Variants for Cataract Open
Our results demonstrate the value of gene-based and single-variant association testing for understanding cataract etiology and uncovering novel genetic risk factors. Our findings also show that cataract-associated genes are significantly e…
View article: Hospital Leader Views on the Family-Centeredness of Pediatric Care
Hospital Leader Views on the Family-Centeredness of Pediatric Care Open
Background: Family-centered care (FCC) contributes to improved health care delivery and outcomes in pediatrics. Objective: To conduct a global survey of hospital leaders’ views on FCC culture, policies, and practices in health care organiz…
View article: Statin Initiation and Dementia Incidence in a Large Health Care System From 1997 to 2020
Statin Initiation and Dementia Incidence in a Large Health Care System From 1997 to 2020 Open
This emulated trial provides Class II evidence that statin initiation is not associated with AD/ADRD or AD incidence after the first year of follow-up.
View article: Understanding participants’ attitudes toward research in the CARE registry
Understanding participants’ attitudes toward research in the CARE registry Open
INTRODUCTION Elucidating barriers and facilitators to research participation is especially important in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) populations, who are significantly underrepresented in Alzheimer's disea…
View article: Increasing representation of Asian American, Native Hawaiian, and Pacific Islander communities in aging, dementia, and caregiving research: An update from the CARE registry
Increasing representation of Asian American, Native Hawaiian, and Pacific Islander communities in aging, dementia, and caregiving research: An update from the CARE registry Open
INTRODUCTION Asian American, Native Hawaiian, and Pacific Islander (AANHPI) communities are among the fastest growing segments of older adults in the United States yet remain underrepresented in aging, dementia, and caregiving research. ME…
View article: Comparison of Human-Delivered Conversation versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States (Preprint)
Comparison of Human-Delivered Conversation versus AI Chatbot Conversation in Increasing Heart Attack Knowledge in Women in the United States (Preprint) Open
BACKGROUND Artificial intelligence (AI) chatbots, driven by advances in natural language processing (NLP), can analyze and generate human language through computational linguistics and machine learning. Despite the rapid development of la…
View article: Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study
Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study Open
Introduction To investigate the association of genetically predicted migraine with the risk of primary open-angle glaucoma (POAG). Methods To estimate the shared genetic basis of migraine and POAG, we conducted genome-wide genetic correlat…
View article: Unraveling the genetic landscape of susceptibility to multiple primary cancers
Unraveling the genetic landscape of susceptibility to multiple primary cancers Open
With advances in cancer screening and treatment, there is a growing population of cancer survivors who may develop subsequent primary cancers. While hereditary cancer syndromes account for only a portion of multiple cancer cases, we sought…
View article: Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups Open
We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry, 58,236 African ancestry, 23,546 Hispanic/Latino and 3,630 Asian ancestry; 96.5% of participants…
View article: Computerized <scp>QT</scp> and <scp>QTc</scp> Measurements From Bedside <scp>ICU</scp> Monitors Are Similar to Those Derived From a Standard 12‐Lead <scp>ECG</scp>
Computerized <span>QT</span> and <span>QTc</span> Measurements From Bedside <span>ICU</span> Monitors Are Similar to Those Derived From a Standard 12‐Lead <span>ECG</span> Open
QT/QTc prolongation is associated with an increased risk for torsade de pointes. In at‐risk hospitalized patients, it is common to obtain a standard 12‐lead electrocardiogram (ECG) for this assessment, but this interrupts patient care. Our…
View article: The relationship between APOE genotype and dementia varies by genetic ancestry and race/ethnicity
The relationship between APOE genotype and dementia varies by genetic ancestry and race/ethnicity Open
Background Some evidence suggests the effect of APOE genotype on dementia risk may vary by race/ethnicity and genetic ancestral background. We evaluated APOE genotype and associated dementia risk by genetic ancestry, with a focus on expand…
View article: Unraveling the genetic landscape of susceptibility to multiple primary cancers
Unraveling the genetic landscape of susceptibility to multiple primary cancers Open
With advances in cancer screening and treatment, there is a growing population of cancer survivors who may develop subsequent primary cancers. While hereditary cancer syndromes account for only a portion of multiple cancer cases, we sought…
View article: Interoceptive brain network mechanisms of mindfulness-based training in healthy adolescents
Interoceptive brain network mechanisms of mindfulness-based training in healthy adolescents Open
Introduction This study evaluated changes in the white matter of the brain and psychological health variables, resulting from a neuroscience-based mindfulness intervention, the Training for Awareness, Resilience, and Action (TARA), in a po…
View article: Integrating Genetic Ancestry into Clinical Care: Accuracy, Utility, and Stakeholder Views
Integrating Genetic Ancestry into Clinical Care: Accuracy, Utility, and Stakeholder Views Open
PURPOSE This study aimed to evaluate the concordance of genetic ancestry reports from different providers, assess the accuracy of genetic ancestry compared to self-identified race and ethnicity (SIRE), and explore patient and provider pers…
View article: Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract
Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract Open
Introduction Cataract is the leading cause of blindness among the elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up to 58%. To date, 55 loci f…
View article: The Relationship Between Barriers to Physical Activity and Depressive Symptoms in Community-Dwelling Women
The Relationship Between Barriers to Physical Activity and Depressive Symptoms in Community-Dwelling Women Open
NCTO1280812 registered January 21, 2011.
View article: Prenatal exposure to social adversity and infant cortisol in the first year of life
Prenatal exposure to social adversity and infant cortisol in the first year of life Open
Exposure to social adversity has been associated with cortisol dysregulation during pregnancy and in later childhood; less is known about how prenatal exposure to social stressors affects postnatal cortisol of infants. In a secondary analy…
View article: Teach the Crisis: arguments for teaching the Cartoon Crisis in primary school
Teach the Crisis: arguments for teaching the Cartoon Crisis in primary school Open
The proposal to turn the so-called Cartoon Crisis into the obligatory history curriculum of the primary school system has been debated publicly over the years. Pros and cons regarding its integration into a teaching environment have been p…
View article: Association between water insecurity and antiretroviral therapy adherence among pregnant and postpartum women in Greater Accra region of Ghana
Association between water insecurity and antiretroviral therapy adherence among pregnant and postpartum women in Greater Accra region of Ghana Open
Background Adherence to antiretroviral therapy (ART) can substantially reduce morbidity and mortality among women living with HIV (WLWH) and prevent vertical transmission of HIV. However, in sub-Saharan Africa (SSA), more than 50% of new m…
View article: Relationships of visual impairment and eye conditions with imaging markers, cognition, and diagnoses of dementia: a bi-directional Mendelian randomization study
Relationships of visual impairment and eye conditions with imaging markers, cognition, and diagnoses of dementia: a bi-directional Mendelian randomization study Open
Objective To evaluate the causal relationships between visual acuity, eye conditions (focusing on cataracts and myopia), and Alzheimer disease (AD) and related dementias. Design Cohort and two sample bi-directional mendelian randomization …